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METMEL SIGNED

Long range-acting drivers of premetastatic niches in melanoma

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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0

 METMEL project word cloud

Explore the words cloud of the METMEL project. It provides you a very rough idea of what is the project "METMEL" about.

soengas    demonstrated    screening    favouring    secreted    lymph    incidence    relevance    lymphangiogenesis    induce    unclear    occurs    proteomic    bear    components    primary    questions    pending    pathologists    novelty    permissive    dynamic    thin    group    dermatologists    nodes    mouse    proteins    treatments    risk    draining    inherent    cells    seemingly    imaging    models    subsequently    drive    genes    clinically    newly    underlying    fastest    lymphatic    acting    therapies    metastasis    crosstalk    rates    melanomas    fraction    progression    vasculature    prognostic    secondly    melanoma    lymphovascular    succumb    link    secretome    distal    biomarkers    invasive    oncologist    lesions    performed    world    indicators    body    sites    mm    physiological    unprecedented    interactions    stages    lymphoreporter    patients    ge    ultimately    disease    immune    lymphoreporters    tumour    rising    ranking    cancer    filtered    proximal    metastatic    mechanisms    whereby    neo    niche   

Project "METMEL" data sheet

The following table provides information about the project.

Coordinator
FUNDACION CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III 

Organization address
address: CALLE MELCHOR FERNANDEZ ALMAGRO 3
city: MADRID
postcode: 28029
website: www.cnio.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 170˙121 €
 EC max contribution 170˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-04-01   to  2020-07-16

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACION CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III ES (MADRID) coordinator 170˙121.00

Map

 Project objective

Melanoma is the cancer with the fastest rising incidence world-wide, and although recent therapies can achieve unprecedented response rates, a significant fraction of patients still succumb to metastatic lesions. Key pending questions in the field are the mechanisms underlying the inherent metastatic behaviour or melanoma, whereby seemingly thin primary lesions (≥2 mm in depth) bear high risk of dissemination to proximal lymph nodes and ultimately, to distal sites. A dynamic crosstalk has been proposed to be established between melanoma cells and the lymphatic vasculature at tumour-draining lymph nodes, favouring an immune-permissive “lymphovascular niche”. However, whether (and how) these lymphovascular interactions occur at distal sites is unclear. The Soengas group has generated unique “Lymphoreporter” melanoma mouse models for non-invasive and whole body imaging of tumour progression. These lymphoreporters demonstrated that primary melanomas induce neo-lymphangiogenesis at distal pre-metastatic sites, already from very early stages of the disease, before dissemination occurs. Proteomic analyses were then performed to identify factors in the melanoma secretome that could drive these long range-acting effects and subsequently filtered these proteins for novelty (i.e. no previous link to melanoma and lymphangiogenesis). Here I will focus on the top-ranking factors in this screening. In particular, I will define the impact of these newly-identified melanoma secreted factors on tumour progression and metastasis, focusing on key components of the lymphovascular niche (i.e. on the crosstalk of tumour- vasculature-immune system). Secondly, I will assess the impact of these genes as prognostic biomarkers and indicators of response to clinically-relevant treatments. These studies will be performed in collaboration with dermatologists, pathologists and oncologist to define the physiological relevance of our work.

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The information about "METMEL" are provided by the European Opendata Portal: CORDIS opendata.

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