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uPROPHET SIGNED

uPROPHET: Urinary PROteomics in Predicting HEart Transplantation outcomes

Total Cost €

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EC-Contrib. €

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Partnership

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 uPROPHET project word cloud

Explore the words cloud of the uPROPHET project. It provides you a very rough idea of what is the project "uPROPHET" about.

graft    biomarker    rejection    validated    margin    standard    subclinical    shortage    immune    tool    signatures    indications    plans    leave    consensus    outcomes    spectroscopy    demonstrating    procedure    monitoring    cardiovascular    probability    instrument    samples    forefront    course    mass    function    hence    adverse    helpful    patients    endomyocardial    classifiers    survival    patient    rests    htx    prognostic    ill    personalised    terminally    quality    business    tissue    reproducibly    transplantation    unpredictable    profiling    immunosuppression    dysfunction    underlying    disease    resolution    monitor    evident    benefit    maximum    uprophet    performance    ventricular    criteria    initially    coupled    inconvenient    profiles    stratification    biopsies    adding    selecting    detect    measuring    competitive    left    innovative    life    eplore    medicine    donor    proof    proteomic    urine    heart    electrophoresis    broaden    invasive    services    renal    clinical    hearts    first    impairment    customer    analogy    adjusting    urinary    translation    greatest    explanted    capillary    risk   

Project "uPROPHET" data sheet

The following table provides information about the project.

Coordinator
KATHOLIEKE UNIVERSITEIT LEUVEN 

Organization address
address: OUDE MARKT 13
city: LEUVEN
postcode: 3000
website: www.kuleuven.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 147˙500 €
 EC max contribution 147˙500 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-PoC
 Funding Scheme ERC-POC
 Starting year 2016
 Duration (year-month-day) from 2016-10-01   to  2018-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KATHOLIEKE UNIVERSITEIT LEUVEN BE (LEUVEN) coordinator 147˙500.00

Map

 Project objective

The proof of concept underlying uPROPHET rests on the EPLORE findings that capillary electrophoresis coupled with high-resolution mass-spectroscopy reproducibly identified unique urinary proteomic (UP) signatures associated with subclinical left ventricular dysfunction, renal impairment and adverse cardiovascular outcomes. Consensus criteria currently applied for the selection of patients for heart transplantation (HTx) leave an inconvenient margin of uncertainty, because of the unpredictable course of the disease and the shortage of donor hearts. Furthermore, monitoring graft function and adjusting immunosuppression remain major challenges after HTx. Endomyocardial biopsies, up to 20 in the first year after HTx, are the standard approach to detect graft rejection, but require an invasive risk-carrying procedure. uPROPHET aims to develop UP profiling: (1) as a prognostic tool helpful in selecting terminally ill heart failure patients for HTx with the greatest probability of survival while adding a maximum of high-quality years to life; and (2) as an instrument to monitor graft performance and immune system activity and to manage immunosuppression. The new UP classifiers will be initially validated by demonstrating analogy between the proteomic profiles in urine and tissue samples of explanted hearts. uPROPHET will show case the translation of state-of-the-art technology into “innovative services”, broaden the indications for UP, and therefore have a major impact on the plans of the business partner measuring the UP profiles. The evident benefit for the customer (patient) is the early and non-invasive stratification of risk in heart failure patients before and after HTx, hence allowing an early, personalised, and targeted approach. Clinical implementation of uPROPHET findings will bring European research to the forefront of the highly competitive fields of biomarker research and personalised medicine and impact on transplantation medicine beyond HTx.

 Publications

year authors and title journal last update
List of publications.
2017 Wen‐Yi Yang, Zhen‐Yu Zhang, Lutgarde Thijs, Nicholas Cauwenberghs, Fang‐Fei Wei, Lotte Jacobs, Aernout Luttun, Peter Verhamme, Tatiana Kuznetsova, Tim S. Nawrot, Jan A. Staessen
Left Ventricular Structure and Function in Relation to Environmental Exposure to Lead and Cadmium
published pages: e004692, ISSN: 2047-9980, DOI: 10.1161/JAHA.116.004692
Journal of the American Heart Association 6/2 2019-06-13
2017 Wen-Yi Yang, Zhen-Yu Zhang, Lutgarde Thijs, Esmée M Bijnens, Bram G Janssen, Charlotte Vanpoucke, Wouter Lefebvre, Nicholas Cauwenberghs, Fang-Fei Wei, Aernout Luttun, Peter Verhamme, Etienne Van Hecke, Tatiana Kuznetsova, Jan D’hooge, Tim S Nawrot, Jan A Staessen
Left ventricular function in relation to chronic residential air pollution in a general population
published pages: 1416-1428, ISSN: 2047-4873, DOI: 10.1177/2047487317715109
European Journal of Preventive Cardiology 24/13 2019-06-13
2017 Zhen-Yu Zhang, Susana Ravassa, Martin Pejchinovski, Wen-Yi Yang, Petra Zürbig, Begoña López, Fang-Fei Wei, Lutgarde Thijs, Lotte Jacobs, Arantxa González, Jens-Uwe Voigt, Peter Verhamme, Tatiana Kuznetsova, Javier Díez, Harald Mischak, Jan A. Staessen
A Urinary Fragment of Mucin-1 Subunit α Is a Novel Biomarker Associated With Renal Dysfunction in the General Population
published pages: 811-820, ISSN: 2468-0249, DOI: 10.1016/j.ekir.2017.03.012
Kidney International Reports 2/5 2019-06-13
2018 Fang-Fei Wei, Anke Raaijmakers, Zhen-Yu Zhang, Theun Pieter van Tienoven, Qi-Fang Huang, Wen-Yi Yang, Lutgarde Thijs, Harry A.J. Struijker-Boudier, Peter Verhamme, Karel Allegaert, Jan A. Staessen
Association between cognition and the retinal microvasculature in 11-year old children born preterm or at term
published pages: 1-7, ISSN: 0378-3782, DOI: 10.1016/j.earlhumdev.2018.01.018
Early Human Development 118 2019-06-13
2018 Qi-Fang Huang, Sander Trenson, Zhen-Yu Zhang, Jan Van Keer, Lucas N.L. Van Aelst, Wen-Yi Yang, Esther Nkuipou-Kenfack, Lutgarde Thijs, Fang-Fei Wei, Blerim Mujaj, Agnieszka Ciarka, Walter Droogné, Johan Vanhaecke, Stefan Janssens, Johan Van Cleemput, Harald Mischak, Jan A. Staessen
Biomarkers to Assess Right Heart Pressures in Recipients of a Heart Transplant
published pages: 1, ISSN: 2373-8731, DOI: 10.1097/TXD.0000000000000783
Transplantation Direct 2019-06-13
2018 Yi-Bang Cheng, Qian-Hui Guo, Dong-Yan Zhang, Ying Wang, Qi-Fang Huang, Chang-Sheng Sheng, Ji-Guang Wang, Jan A. Staessen, Yan Li
Association of pulse wave velocity with single nucleotide polymorphisms related to parathyroid hormone
published pages: 222-230, ISSN: 0803-7051, DOI: 10.1080/08037051.2018.1445961
Blood Pressure 27/4 2019-06-13
2016 Zhen-Yu Zhang, Susana Ravassa, Wen-Yi Yang, Thibault Petit, Martin Pejchinovski, Petra Zürbig, Begoña López, Fang-Fei Wei, Claudia Pontillo, Lutgarde Thijs, Lotte Jacobs, Arantxa González, Thomas Koeck, Christian Delles, Jens-Uwe Voigt, Peter Verhamme, Tatiana Kuznetsova, Javier Díez, Harald Mischak, Jan A. Staessen
Diastolic Left Ventricular Function in Relation to Urinary and Serum Collagen Biomarkers in a General Population
published pages: e0167582, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0167582
PLOS ONE 11/12 2019-06-13
2018 Dries S. Martens, Fang-Fei Wei, Bianca Cox, Michelle Plusquin, Lutgarde Thijs, Ellen Winckelmans, Zhen-Yu Zhang, Tim S. Nawrot, Jan A. Staessen
Retinal microcirculation and leukocyte telomere length in the general population
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-25165-6
Scientific Reports 8/1 2019-06-13
2017 Ljupcho Efremov, Wen-Yi Yang, Lotte Jacobs, Lutgarde Thijs, Tatiana Kuznetsova, Harry A.J. Struijker-Boudier, Jan A. Staessen
Post-processing reproducibility of the structural characteristics of the common carotid artery in a Flemish population
published pages: 9-17, ISSN: 1872-9312, DOI: 10.1016/j.artres.2017.04.007
Artery Research 19 2019-06-13
2018 Wen-Yi Yang, Jan A. Staessen
Letter to editor: Blood pressure, hypertension and lead exposure
published pages: , ISSN: 1476-069X, DOI: 10.1186/s12940-018-0364-3
Environmental Health 17/1 2019-06-13
2018 Wen-Yi Yang, Ljupcho Efremov, Blerim Mujaj, Zhen-Yu Zhang, Fang-Fei Wei, Qi-Fang Huang, Lutgarde Thijs, Thomas Vanassche, Tim S. Nawrot, Jan A. Staessen
Association of office and ambulatory blood pressure with blood lead in workers before occupational exposure
published pages: 14-24, ISSN: 1933-1711, DOI: 10.1016/j.jash.2017.10.010
Journal of the American Society of Hypertension 12/1 2019-06-13
2018 Fang-Fei Wei, Sander Trenson, Pierre Monney, Wen-Yi Yang, Menno Pruijm, Zhen-Yu Zhang, Yassine Bouatou, Qi-Fang Huang, Belen Ponte, Pierre-Yves Martin, Lutgarde Thijs, Tatiana Kuznetsova, Karel Allegaert, Stefan Janssens, Cees Vermeer, Peter Verhamme, Michel Burnier, Murielle Bochud, Georg Ehret, Jan A. Staessen
Epidemiological and histological findings implicate matrix Gla protein in diastolic left ventricular dysfunction
published pages: e0193967, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0193967
PLOS ONE 13/3 2019-06-13
2017 Zhen‐Yu Zhang, Susana Ravassa, Esther Nkuipou‐Kenfack, Wen‐Yi Yang, Shona M. Kerr, Thomas Koeck, Archie Campbell, Tatiana Kuznetsova, Harald Mischak, Sandosh Padmanabhan, Anna F. Dominiczak, Christian Delles, Jan A. Staessen
Novel Urinary Peptidomic Classifier Predicts Incident Heart Failure
published pages: e005432, ISSN: 2047-9980, DOI: 10.1161/JAHA.116.005432
Journal of the American Heart Association 6/8 2019-06-13
2017 Lotte Jacobs, Alexandre Persu, Qi-Fang Huang, Jean-Philippe Lengelé, Lutgarde Thijs, Frank Hammer, Wen-Yi Yang, Zhen-Yu Zhang, Jean Renkin, Peter Sinnaeve, Fang-Fei Wei, Agnès Pasquet, Fadl Elmula M. Fadl Elmula, Marc Carlier, Arif Elvan, Cora Wunder, Sverre E. Kjeldsen, Stefan W. Toennes, Stefan Janssens, Peter Verhamme, Jan A. Staessen
Results of a randomized controlled pilot trial of intravascular renal denervation for management of treatment-resistant hypertension
published pages: 321-331, ISSN: 0803-7051, DOI: 10.1080/08037051.2017.1320939
Blood Pressure 26/6 2019-06-13
2018 Fang-Fei Wei, Zhen-Yu Zhang, Qi-Fang Huang, Wen-Yi Yang, Jan A. Staessen
Resistant hypertension
published pages: 1031-1042, ISSN: 0022-9032, DOI: 10.5603/KP.a2018.0129
Kardiologia Polska 76/7 2019-06-13
2017 Wen-Yi Yang, Thibault Petit, Nicholas Cauwenberghs, Zhen-Yu Zhang, Chang-Sheng Sheng, Lutgarde Thijs, Erika Salvi, Benedetta Izzi, Christophe Vandenbriele, Fang-Fei Wei, Yu-Mei Gu, Lotte Jacobs, Lorena Citterio, Simona Delli Carpini, Cristina Barlassina, Daniele Cusi, Marc F. Hoylaerts, Peter Verhamme, Tatiana Kuznetsova, Jan A. Staessen
PEAR1 is not a major susceptibility gene for cardiovascular disease in a Flemish population
published pages: , ISSN: 1471-2350, DOI: 10.1186/s12881-017-0411-x
BMC Medical Genetics 18/1 2019-06-13
2017 Claudia Pontillo, Zhen-Yu Zhang, Joost P. Schanstra, Lotte Jacobs, Petra Zürbig, Lutgarde Thijs, Adela Ramírez-Torres, Hiddo J.L. Heerspink, Morten Lindhardt, Ronald Klein, Trevor Orchard, Massimo Porta, Rudolf W. Bilous, Nishi Charturvedi, Peter Rossing, Antonia Vlahou, Eva Schepers, Griet Glorieux, William Mullen, Christian Delles, Peter Verhamme, Raymond Vanholder, Jan A. Staessen, Harald Mischak, Joachim Jankowski
Prediction of Chronic Kidney Disease Stage 3 by CKD273, a Urinary Proteomic Biomarker
published pages: 1066-1075, ISSN: 2468-0249, DOI: 10.1016/j.ekir.2017.06.004
Kidney International Reports 2/6 2019-06-13
2017 Qi-Fang Huang, Sander Trenson, Zhen-Yu Zhang, Wen-Yi Yang, Lucas Van Aelst, Esther Nkuipou-Kenfack, Fang-Fei Wei, Blerim Mujaj, Lutgarde Thijs, Agnieszka Ciarka, Jerome Zoidakis, Walter Droogné, Antonia Vlahou, Stefan Janssens, Johan Vanhaecke, Johan Van Cleemput, Jan A. Staessen
Urinary Proteomics in Predicting Heart Transplantation Outcomes (uPROPHET)—Rationale and database description
published pages: e0184443, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0184443
PLOS ONE 12/9 2019-06-13

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