uPROPHET SIGNED
uPROPHET: Urinary PROteomics in Predicting HEart Transplantation outcomes
Total Cost €
0EC-Contrib. €
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0uPROPHET project word cloud
Explore the words cloud of the uPROPHET project. It provides you a very rough idea of what is the project "uPROPHET" about.
Project "uPROPHET" data sheet
The following table provides information about the project.
| Coordinator |
KATHOLIEKE UNIVERSITEIT LEUVEN
Organization address contact info |
| Coordinator Country | Belgium [BE] |
| Total cost | 147˙500 € |
| EC max contribution | 147˙500 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2015-PoC |
| Funding Scheme | ERC-POC |
| Starting year | 2016 |
| Duration (year-month-day) | from 2016-10-01 to 2018-03-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | KATHOLIEKE UNIVERSITEIT LEUVEN | BE (LEUVEN) | coordinator | 147˙500.00 |
Map
Project objective
The proof of concept underlying uPROPHET rests on the EPLORE findings that capillary electrophoresis coupled with high-resolution mass-spectroscopy reproducibly identified unique urinary proteomic (UP) signatures associated with subclinical left ventricular dysfunction, renal impairment and adverse cardiovascular outcomes. Consensus criteria currently applied for the selection of patients for heart transplantation (HTx) leave an inconvenient margin of uncertainty, because of the unpredictable course of the disease and the shortage of donor hearts. Furthermore, monitoring graft function and adjusting immunosuppression remain major challenges after HTx. Endomyocardial biopsies, up to 20 in the first year after HTx, are the standard approach to detect graft rejection, but require an invasive risk-carrying procedure. uPROPHET aims to develop UP profiling: (1) as a prognostic tool helpful in selecting terminally ill heart failure patients for HTx with the greatest probability of survival while adding a maximum of high-quality years to life; and (2) as an instrument to monitor graft performance and immune system activity and to manage immunosuppression. The new UP classifiers will be initially validated by demonstrating analogy between the proteomic profiles in urine and tissue samples of explanted hearts. uPROPHET will show case the translation of state-of-the-art technology into “innovative services”, broaden the indications for UP, and therefore have a major impact on the plans of the business partner measuring the UP profiles. The evident benefit for the customer (patient) is the early and non-invasive stratification of risk in heart failure patients before and after HTx, hence allowing an early, personalised, and targeted approach. Clinical implementation of uPROPHET findings will bring European research to the forefront of the highly competitive fields of biomarker research and personalised medicine and impact on transplantation medicine beyond HTx.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2017 |
Wenâ€Yi Yang, Zhenâ€Yu Zhang, Lutgarde Thijs, Nicholas Cauwenberghs, Fangâ€Fei Wei, Lotte Jacobs, Aernout Luttun, Peter Verhamme, Tatiana Kuznetsova, Tim S. Nawrot, Jan A. Staessen Left Ventricular Structure and Function in Relation to Environmental Exposure to Lead and Cadmium published pages: e004692, ISSN: 2047-9980, DOI: 10.1161/JAHA.116.004692 |
Journal of the American Heart Association 6/2 | 2019-06-13 |
| 2017 |
Wen-Yi Yang, Zhen-Yu Zhang, Lutgarde Thijs, Esmée M Bijnens, Bram G Janssen, Charlotte Vanpoucke, Wouter Lefebvre, Nicholas Cauwenberghs, Fang-Fei Wei, Aernout Luttun, Peter Verhamme, Etienne Van Hecke, Tatiana Kuznetsova, Jan D’hooge, Tim S Nawrot, Jan A Staessen Left ventricular function in relation to chronic residential air pollution in a general population published pages: 1416-1428, ISSN: 2047-4873, DOI: 10.1177/2047487317715109 |
European Journal of Preventive Cardiology 24/13 | 2019-06-13 |
| 2017 |
Zhen-Yu Zhang, Susana Ravassa, Martin Pejchinovski, Wen-Yi Yang, Petra Zürbig, Begoña López, Fang-Fei Wei, Lutgarde Thijs, Lotte Jacobs, Arantxa González, Jens-Uwe Voigt, Peter Verhamme, Tatiana Kuznetsova, Javier DÃez, Harald Mischak, Jan A. Staessen A Urinary Fragment of Mucin-1 Subunit α Is a Novel Biomarker Associated With Renal Dysfunction in the General Population published pages: 811-820, ISSN: 2468-0249, DOI: 10.1016/j.ekir.2017.03.012 |
Kidney International Reports 2/5 | 2019-06-13 |
| 2018 |
Fang-Fei Wei, Anke Raaijmakers, Zhen-Yu Zhang, Theun Pieter van Tienoven, Qi-Fang Huang, Wen-Yi Yang, Lutgarde Thijs, Harry A.J. Struijker-Boudier, Peter Verhamme, Karel Allegaert, Jan A. Staessen Association between cognition and the retinal microvasculature in 11-year old children born preterm or at term published pages: 1-7, ISSN: 0378-3782, DOI: 10.1016/j.earlhumdev.2018.01.018 |
Early Human Development 118 | 2019-06-13 |
| 2018 |
Qi-Fang Huang, Sander Trenson, Zhen-Yu Zhang, Jan Van Keer, Lucas N.L. Van Aelst, Wen-Yi Yang, Esther Nkuipou-Kenfack, Lutgarde Thijs, Fang-Fei Wei, Blerim Mujaj, Agnieszka Ciarka, Walter Droogné, Johan Vanhaecke, Stefan Janssens, Johan Van Cleemput, Harald Mischak, Jan A. Staessen Biomarkers to Assess Right Heart Pressures in Recipients of a Heart Transplant published pages: 1, ISSN: 2373-8731, DOI: 10.1097/TXD.0000000000000783 |
Transplantation Direct | 2019-06-13 |
| 2018 |
Yi-Bang Cheng, Qian-Hui Guo, Dong-Yan Zhang, Ying Wang, Qi-Fang Huang, Chang-Sheng Sheng, Ji-Guang Wang, Jan A. Staessen, Yan Li Association of pulse wave velocity with single nucleotide polymorphisms related to parathyroid hormone published pages: 222-230, ISSN: 0803-7051, DOI: 10.1080/08037051.2018.1445961 |
Blood Pressure 27/4 | 2019-06-13 |
| 2016 |
Zhen-Yu Zhang, Susana Ravassa, Wen-Yi Yang, Thibault Petit, Martin Pejchinovski, Petra Zürbig, Begoña López, Fang-Fei Wei, Claudia Pontillo, Lutgarde Thijs, Lotte Jacobs, Arantxa González, Thomas Koeck, Christian Delles, Jens-Uwe Voigt, Peter Verhamme, Tatiana Kuznetsova, Javier DÃez, Harald Mischak, Jan A. Staessen Diastolic Left Ventricular Function in Relation to Urinary and Serum Collagen Biomarkers in a General Population published pages: e0167582, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0167582 |
PLOS ONE 11/12 | 2019-06-13 |
| 2018 |
Dries S. Martens, Fang-Fei Wei, Bianca Cox, Michelle Plusquin, Lutgarde Thijs, Ellen Winckelmans, Zhen-Yu Zhang, Tim S. Nawrot, Jan A. Staessen Retinal microcirculation and leukocyte telomere length in the general population published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-25165-6 |
Scientific Reports 8/1 | 2019-06-13 |
| 2017 |
Ljupcho Efremov, Wen-Yi Yang, Lotte Jacobs, Lutgarde Thijs, Tatiana Kuznetsova, Harry A.J. Struijker-Boudier, Jan A. Staessen Post-processing reproducibility of the structural characteristics of the common carotid artery in a Flemish population published pages: 9-17, ISSN: 1872-9312, DOI: 10.1016/j.artres.2017.04.007 |
Artery Research 19 | 2019-06-13 |
| 2018 |
Wen-Yi Yang, Jan A. Staessen Letter to editor: Blood pressure, hypertension and lead exposure published pages: , ISSN: 1476-069X, DOI: 10.1186/s12940-018-0364-3 |
Environmental Health 17/1 | 2019-06-13 |
| 2018 |
Wen-Yi Yang, Ljupcho Efremov, Blerim Mujaj, Zhen-Yu Zhang, Fang-Fei Wei, Qi-Fang Huang, Lutgarde Thijs, Thomas Vanassche, Tim S. Nawrot, Jan A. Staessen Association of office and ambulatory blood pressure with blood lead in workers before occupational exposure published pages: 14-24, ISSN: 1933-1711, DOI: 10.1016/j.jash.2017.10.010 |
Journal of the American Society of Hypertension 12/1 | 2019-06-13 |
| 2018 |
Fang-Fei Wei, Sander Trenson, Pierre Monney, Wen-Yi Yang, Menno Pruijm, Zhen-Yu Zhang, Yassine Bouatou, Qi-Fang Huang, Belen Ponte, Pierre-Yves Martin, Lutgarde Thijs, Tatiana Kuznetsova, Karel Allegaert, Stefan Janssens, Cees Vermeer, Peter Verhamme, Michel Burnier, Murielle Bochud, Georg Ehret, Jan A. Staessen Epidemiological and histological findings implicate matrix Gla protein in diastolic left ventricular dysfunction published pages: e0193967, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0193967 |
PLOS ONE 13/3 | 2019-06-13 |
| 2017 |
Zhenâ€Yu Zhang, Susana Ravassa, Esther Nkuipouâ€Kenfack, Wenâ€Yi Yang, Shona M. Kerr, Thomas Koeck, Archie Campbell, Tatiana Kuznetsova, Harald Mischak, Sandosh Padmanabhan, Anna F. Dominiczak, Christian Delles, Jan A. Staessen Novel Urinary Peptidomic Classifier Predicts Incident Heart Failure published pages: e005432, ISSN: 2047-9980, DOI: 10.1161/JAHA.116.005432 |
Journal of the American Heart Association 6/8 | 2019-06-13 |
| 2017 |
Lotte Jacobs, Alexandre Persu, Qi-Fang Huang, Jean-Philippe Lengelé, Lutgarde Thijs, Frank Hammer, Wen-Yi Yang, Zhen-Yu Zhang, Jean Renkin, Peter Sinnaeve, Fang-Fei Wei, Agnès Pasquet, Fadl Elmula M. Fadl Elmula, Marc Carlier, Arif Elvan, Cora Wunder, Sverre E. Kjeldsen, Stefan W. Toennes, Stefan Janssens, Peter Verhamme, Jan A. Staessen Results of a randomized controlled pilot trial of intravascular renal denervation for management of treatment-resistant hypertension published pages: 321-331, ISSN: 0803-7051, DOI: 10.1080/08037051.2017.1320939 |
Blood Pressure 26/6 | 2019-06-13 |
| 2018 |
Fang-Fei Wei, Zhen-Yu Zhang, Qi-Fang Huang, Wen-Yi Yang, Jan A. Staessen Resistant hypertension published pages: 1031-1042, ISSN: 0022-9032, DOI: 10.5603/KP.a2018.0129 |
Kardiologia Polska 76/7 | 2019-06-13 |
| 2017 |
Wen-Yi Yang, Thibault Petit, Nicholas Cauwenberghs, Zhen-Yu Zhang, Chang-Sheng Sheng, Lutgarde Thijs, Erika Salvi, Benedetta Izzi, Christophe Vandenbriele, Fang-Fei Wei, Yu-Mei Gu, Lotte Jacobs, Lorena Citterio, Simona Delli Carpini, Cristina Barlassina, Daniele Cusi, Marc F. Hoylaerts, Peter Verhamme, Tatiana Kuznetsova, Jan A. Staessen PEAR1 is not a major susceptibility gene for cardiovascular disease in a Flemish population published pages: , ISSN: 1471-2350, DOI: 10.1186/s12881-017-0411-x |
BMC Medical Genetics 18/1 | 2019-06-13 |
| 2017 |
Claudia Pontillo, Zhen-Yu Zhang, Joost P. Schanstra, Lotte Jacobs, Petra Zürbig, Lutgarde Thijs, Adela RamÃrez-Torres, Hiddo J.L. Heerspink, Morten Lindhardt, Ronald Klein, Trevor Orchard, Massimo Porta, Rudolf W. Bilous, Nishi Charturvedi, Peter Rossing, Antonia Vlahou, Eva Schepers, Griet Glorieux, William Mullen, Christian Delles, Peter Verhamme, Raymond Vanholder, Jan A. Staessen, Harald Mischak, Joachim Jankowski Prediction of Chronic Kidney Disease Stage 3 by CKD273, a Urinary Proteomic Biomarker published pages: 1066-1075, ISSN: 2468-0249, DOI: 10.1016/j.ekir.2017.06.004 |
Kidney International Reports 2/6 | 2019-06-13 |
| 2017 |
Qi-Fang Huang, Sander Trenson, Zhen-Yu Zhang, Wen-Yi Yang, Lucas Van Aelst, Esther Nkuipou-Kenfack, Fang-Fei Wei, Blerim Mujaj, Lutgarde Thijs, Agnieszka Ciarka, Jerome Zoidakis, Walter Droogné, Antonia Vlahou, Stefan Janssens, Johan Vanhaecke, Johan Van Cleemput, Jan A. Staessen Urinary Proteomics in Predicting Heart Transplantation Outcomes (uPROPHET)—Rationale and database description published pages: e0184443, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0184443 |
PLOS ONE 12/9 | 2019-06-13 |
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