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HypoSens SIGNED

Nano-confined photonic system for detection of breast cancer spread to the lymph nodes

Total Cost €

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EC-Contrib. €

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Partnership

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Outcomes and
results

HypoSens project word cloud

Explore the words cloud of the HypoSens project. It provides you a very rough idea of what is the project "HypoSens" about.

tumor quality prognosis fast metastatic gastric enabled nano tumour near million signals economic temperature prognostic approximate metastasis infrared node demonstration biopsy specially correlates bad body lymph vulval hospitals progression clinical antibody accurate collected personalised initial injected nodes therapy consist additional concentration validation optical diagnostics expectancy sensors industrial patients involvement clinicians alternative register porphyrin shaping breakthrough renal women affordable particles diagnosis data functionalised invasive sentinel colorectal solution worldwide containing device media stages staging cancer life tool moiety imaging accepted oncologists scattering burden treatment oxygen patient societal later prompt procedure designed decide markets breast local surgical cells strategically hyposens vision options wavefront

Project "HypoSens" data sheet

The following table provides information about the project.

Coordinator	ACONDICIONAMIENTO TARRASENSE ASSOCIACION Organization address address: CARRER DE LA INNOVACIO 2 city: TERRASSA postcode: 8225 website: www.leitat.org contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Spain [ES]
Project website	http://hyposens.eu/
Total cost	3˙998˙646 €
EC max contribution	3˙998˙646 € (100%)
Programme	1. H2020-EU.2.1.1. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Information and Communication Technologies (ICT))
Code Call	H2020-ICT-2016-1
Funding Scheme	RIA
Starting year	2016
Duration (year-month-day)	from 2016-11-01 to 2019-10-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	ACONDICIONAMIENTO TARRASENSE ASSOCIACION ACONDICIONAMIENTO TARRASENSE ASSOCIACION Organization address address: CARRER DE LA INNOVACIO 2 city: TERRASSA postcode: 8225 website: www.leitat.org contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (TERRASSA)	coordinator	672˙083.00
2	TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY Organization address address: SENATE BUILDING TECHNION CITY city: HAIFA postcode: 32000 website: www.technion.ac.il contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IL (HAIFA)	participant	539˙041.00
3	MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV Organization address address: HOFGARTENSTRASSE 8 city: MUENCHEN postcode: 80539 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUENCHEN)	participant	490˙981.00
4	FUNDACION RIOJA SALUD-FRS FUNDACION RIOJA SALUD-FRS Organization address address: CALLE PIQUERAS 98 city: LOGRONO postcode: 26006 website: www.riojasalud.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (LOGRONO)	participant	407˙677.00
5	SOFIA UNIVERSITY ST KLIMENT OHRIDSKI SOFIA UNIVERSITY ST KLIMENT OHRIDSKI Organization address address: BUL TZAR OSVOBODITEL 15 city: SOFIA postcode: 1504 website: www.uni-sofia.bg contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BG (SOFIA)	participant	403˙162.00
6	BCB Informatica y Control S.L. BCB Informatica y Control S.L. Organization address address: Calle Fernando el Catolico 11/2B DCHA city: Madrid postcode: 28015 website: www.bcb.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (Madrid)	participant	372˙500.00
7	OBELIS SA OBELIS SA Organization address address: BOULEVARD GENERAL WAHIS 53 city: BRUXELLES postcode: 1030 website: www.obelis.net contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (BRUXELLES)	participant	319˙200.00
8	FUNDACION PARA EL DESARROLLO Y LA INNOVACION TECNOLOGICA FUNDACION PARA EL DESARROLLO Y LA INNOVACION TECNOLOGICA Organization address address: PASEO CASTELLANA NUM 141 PLANTA 18 EDIFICIO CUZCO IV city: MADRID postcode: 28046 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (MADRID)	participant	276˙449.00
9	KNOWLEDGE INNOVATION MARKET S.L. KNOWLEDGE INNOVATION MARKET S.L. Organization address address: CALLE VENEZUELA 103 PLANTA 1 PUERTA city: BARCELONA postcode: 8019 website: www.kimglobal.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BARCELONA)	participant	240˙250.00
10	UFO UFO Organization address address: BULEVARDI ZOGU I, BUILDING 2 city: TIRANA postcode: 1000 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AL (TIRANA)	participant	193˙750.00
11	TECNOLOGIAS AVANZADAS INSPIRALIA SL TECNOLOGIAS AVANZADAS INSPIRALIA SL Organization address address: CALLE MIGUEL VILLANUEVA 2 6 PISO PUERTA 3 city: LOGRONO postcode: 26001 website: http://www.itav.es/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (LOGRONO)	participant	83˙551.00

Map

Project objective

The Vision of HypoSens is to develop a widely accepted,non-invasive and crucial prognostic tool for breast cancer progression in early stages to help clinicians and specially oncologists to decide about prompt therapy approaches to patients and improve quality of life and expectancy. Our breakthrough research will focus on the development, pre-clinical and clinical validation, and industrial demonstration of a unique all optical cancer prognostic system that will determine presence of cancer cells in the breast lymph nodes and characterize them, which correlates with presence of metastasis and bad prognosis. HypoSens prognostic system will consist of a non-invasive Near-infrared imaging device able to register signals through scattering media enabled by the implementation of wavefront shaping,that will process data collected by injected tumour-targeted body antibody functionalised nano-particles containing porphyrin sensors that will determine local oxygen concentration and local temperature distribution in the cancer cells.The HypoSens imaging system is strategically designed to offer a non-invasive alternative to the Sentinel Lymph Node Biopsy,the current surgical procedure for breast cancer staging. With an approximate cost of 60,000€ per device unit and additional 5,000€ per patient, the device is an affordable, accurate, easy to use prognostic solution for clinicians towards more accurate and fast diagnostics and personalised treatment options.The initial target of the project is metastatic breast cancer, with potential later involvement in other cancer markets, e.g. vulval, renal, colorectal, gastric etc (via the use of different tumor-targeting moiety).With an estimated 1.7 million new cases each year, breast cancer is the most common cancer among women worldwide.Its low cost will enable a wide and fast take-up by clinicians and hospitals leading to an important reduction of the economic and societal burden related to the diagnosis and treatment of cancer.

Deliverables

List of deliverables.
Project video	Websites, patent fillings, videos etc.	2020-03-11 14:36:19
Dissemination Kit	Documents, reports	2020-03-11 14:36:22
Obtaining review board approval	Documents, reports	2020-03-11 14:36:15
Market Analysis	Documents, reports	2019-11-18 11:23:42
Project website with content for public consumption	Websites, patent fillings, videos etc.	2019-11-18 11:23:42

Take a look to the deliverables list in detail: detailed list of HypoSens deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	E. Heinrich, Yu. Avlasevich, S. Baluschev, K. Landfester Mixed benzo- naphthoporphyrins for broadband-excited photon energy annihilation upconversion published pages: , ISSN: , DOI:	20th European Symposium on Organic Chemistry	2019-12-17
2019	Nadzeya Nazarova, Yuri Avlasevich, Katharina Landfester, Stanislav Baluschev Allâ€Optical Temperature Sensing in Organogel Matrices via Annihilation Upconversion published pages: 1020-1026, ISSN: 2367-0932, DOI: 10.1002/cptc.201900093	ChemPhotoChem 3/10	2019-11-22
2018	N. V. Nazarova, Yu. S. Avlasevich, K. Landfester, S. Baluschev Stimuli-responsive protection of optically excited triplet ensembles against deactivation by molecular oxygen published pages: , ISSN: 1477-9226, DOI: 10.1039/c7dt03698a	Dalton Transactions	2019-11-18
2018	Ernesta Heinrich, Yuri Avlasevich, Katharina Landfester, Stanislav Baluschev Annihilation upconversion: harvesting the entire deep-red spectral range of the sun irradiation published pages: 1, ISSN: 1947-7988, DOI: 10.1117/1.JPE.8.022002	Journal of Photonics for Energy 8/02	2019-11-18
2019	Kartheek Katta, Dmitry Busko, Yuri Avlasevich, Katharina Landfester, Stanislav Baluschev, Rafael MuÃ±oz-EspÃ Ceria/polymer nanocontainers for high-performance encapsulation of fluorophores published pages: 522-530, ISSN: 2190-4286, DOI: 10.3762/bjnano.10.53	Beilstein Journal of Nanotechnology 10	2019-11-18
2018	Kartheek Katta, Dmitry Busko, Katharina Landfester, Stanislav Baluschev, Rafael MuÃ±oz-EspÃ Inorganic Protection of Polymer Nanocapsules: A Strategy to Improve the Efficiency of Encapsulated Optically Active Molecules published pages: 1356-1362, ISSN: 0021-2148, DOI: 10.1002/ijch.201800111	Israel Journal of Chemistry 58/12	2019-11-18

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