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BrainBIT SIGNED

All-optical brain-to-brain behaviour and information transfer

Total Cost €

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EC-Contrib. €

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Partnership

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Project "BrainBIT" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITA DEGLI STUDI DI FIRENZE 

Organization address
address: Piazza San Marco 4
city: Florence
postcode: 50121
website: http://www.unifi.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Project website http://bio.lens.unifi.it/research-projects/
 Total cost 2˙370˙250 €
 EC max contribution 2˙370˙250 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-AdG
 Funding Scheme ERC-ADG
 Starting year 2016
 Duration (year-month-day) from 2016-12-01   to  2021-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI FIRENZE IT (Florence) coordinator 1˙900˙000.00
2    CONSIGLIO NAZIONALE DELLE RICERCHE IT (ROMA) participant 237˙250.00
3    FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA IT (GENOVA) participant 233˙000.00

Map

 Project objective

Exchange of information between different brains usually takes place through the interaction between bodies and the external environment. The ultimate goal of this project is to establish a novel paradigm of brain-to-brain communication based on direct full-optical recording and controlled stimulation of neuronal activity in different subjects. To pursue this challenging objective, we propose to develop optical technologies well beyond the state of the art for simultaneous neuronal “reading” and “writing” across large volumes and with high spatial and temporal resolution, targeted to the transfer of advantageous behaviour in physiological and pathological conditions. We will perform whole-brain high-resolution imaging in zebrafish larvae to disentangle the activity patterns related to different tasks. We will then use these patterns as stimulation templates in other larvae to investigate spatio-temporal subject-invariant signatures of specific behavioural states. This ‘pump and probe’ strategy will allow gaining deep insights into the complex relationship between neuronal activity and subject behaviour. To move towards clinics-oriented studies on brain stimulation therapies, we will complement whole-brain experiments in zebrafish with large area functional imaging and optostimulation in mammals. We will investigate all-optical brain-to-brain information transfer to boost an advantageous behaviour, i.e. motor recovery, in a mouse model of stroke. Mice showing more effective responses to rehabilitation will provide neuronal activity templates to be elicited in other animals, in order to increase rehabilitation efficiency. We strongly believe that the implementation of new technologies for all-optical transfer of behaviour between different subjects will offer unprecedented views of neuronal activity in healthy and injured brain, paving the way to more effective brain stimulation therapies.

 Publications

year authors and title journal last update
List of publications.
2019 Claudia Alia, Marco Terrigno, Irene Busti, Federico Cremisi, Matteo Caleo
Pluripotent Stem Cells for Brain Repair: Protocols and Preclinical Applications in Cortical and Hippocampal Pathologies
published pages: , ISSN: 1662-453X, DOI: 10.3389/fnins.2019.00684
Frontiers in Neuroscience 13 2020-02-06
2018 Di Giovanna, Antonino Paolo; Tibo, Alessandro; Silvestri, Ludovico; Müllenbroich, Marie Caroline; Costantini, Irene; Allegra Mascaro, Anna Letizia; Sacconi, Leonardo; Frasconi, Paolo; Pavone, Francesco Saverio
Whole-brain vasculature reconstruction at the single capillary level
published pages: , ISSN: 2045-2322, DOI: 10.1101/191502
Scientific Reports 2 2019-10-03
2019 Elena Montagni, Francesco Resta, Emilia Conti, Alessandro Scaglione, Maria Pasquini, Silvestro Micera, Anna Letizia Allegra Mascaro, Francesco Saverio Pavone
Wide-field imaging of cortical neuronal activity with red-shifted functional indicators during motor task execution
published pages: 74001, ISSN: 0022-3727, DOI: 10.1088/1361-6463/aaf26c
Journal of Physics D: Applied Physics 52/7 2019-07-30
2019 Marco Pisanello, Filippo Pisano, Minsuk Hyun, Emanuela Maglie, Antonio Balena, Massimo De Vittorio, Bernardo L. Sabatini, Ferruccio Pisanello
The Three-Dimensional Signal Collection Field for Fiber Photometry in Brain Tissue
published pages: , ISSN: 1662-453X, DOI: 10.3389/fnins.2019.00082
Frontiers in Neuroscience 13 2019-07-30
2017 L. Turrini, C. Fornetto, G. Marchetto, M. C. Müllenbroich, N. Tiso, A. Vettori, F. Resta, A. Masi, G. Mannaioni, F. S. Pavone, F. Vanzi
Optical mapping of neuronal activity during seizures in zebrafish
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-03087-z
Scientific Reports 7/1 2019-08-30
2019 Antonino Paolo Di Giovanna, Caterina Credi, Alessandra Franceschini, Marie Caroline Müllenbroich, Ludovico Silvestri, Francesco Saverio Pavone
Tailored Sample Mounting for Light-Sheet Fluorescence Microscopy of Clarified Specimens by Polydimethylsiloxane Casting
published pages: , ISSN: 1662-5129, DOI: 10.3389/fnana.2019.00035
Frontiers in Neuroanatomy 13 2019-07-30
2019 Giuseppe Sancataldo, Ludovico Silvestri, Anna Letizia Allegra Mascaro, Leonardo Sacconi, Francesco Saverio Pavone
Advanced fluorescence microscopy for in vivo imaging of neuronal activity
published pages: 758, ISSN: 2334-2536, DOI: 10.1364/optica.6.000758
Optica 6/6 2019-07-30
2019 Antonino Paolo Di Giovanna, Alessandro Tibo, Ludovico Silvestri, Marie Caroline Müllenbroich, Irene Costantini, Anna Letizia Allegra Mascaro, Leonardo Sacconi, Paolo Frasconi, Francesco Saverio Pavone
Publisher Correction: Whole-Brain Vasculature Reconstruction at the Single Capillary Level
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-42216-8
Scientific Reports 9/1 2019-07-30
2017 L. Turrini, C. Fornetto, G. Marchetto, M. C. Müllenbroich, N. Tiso, A. Vettori, F. Resta, A. Masi, G. Mannaioni, F. S. Pavone, F. Vanzi
Optical mapping of neuronal activity during seizures in zebrafish
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-03087-z
Scientific Reports 7/1 2019-07-30
2019 Giuseppe Sancataldo, Ludovico Silvestri, Anna Letizia Allegra Mascaro, Leonardo Sacconi, Francesco Saverio Pavone
Advanced fluorescence microscopy for in vivo imaging of neuronal activity
published pages: 758, ISSN: 2334-2536, DOI: 10.1364/optica.6.000758
Optica 6/6 2019-08-30
2018 Leonardo Sileo, Sebastian H. Bitzenhofer, Barbara Spagnolo, Jastyn A. Pöpplau, Tobias Holzhammer, Marco Pisanello, Filippo Pisano, Elisa Bellistri, Emanuela Maglie, Massimo De Vittorio, Patrick Ruther, Ileana L. Hanganu-Opatz, Ferruccio Pisanello
Tapered Fibers Combined With a Multi-Electrode Array for Optogenetics in Mouse Medial Prefrontal Cortex
published pages: , ISSN: 1662-453X, DOI: 10.3389/fnins.2018.00771
Frontiers in Neuroscience 12 2019-07-30
2019 Antonino Paolo Di Giovanna, Alessandro Tibo, Ludovico Silvestri, Marie Caroline Müllenbroich, Irene Costantini, Anna Letizia Allegra Mascaro, Leonardo Sacconi, Paolo Frasconi, Francesco Saverio Pavone
Publisher Correction: Whole-Brain Vasculature Reconstruction at the Single Capillary Level
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-42216-8
Scientific Reports 9/1 2019-08-30
2018 M. Pisanello, F. Pisano, M. Hyun, E. Maglie, Antonio Balena, M. De Vittorio, B. L. Sabatini, F. Pisanello
Analytical and empirical measurement of fiber photometry signal volume in brain tissue
published pages: , ISSN: , DOI:
2019-06-13
2017 Pavone, Francesco; Costantini, Irene; Di Giovanna, Antonino; Silvestri, Ludovico; Mascaro, Anna; Frasconi, Paolo; Sacconi, Leonardo; Tibo, Alessandro; Muellenbroich, Marie
Whole-brain vasculature reconstruction at the single capillary level
published pages: , ISSN: , DOI: 10.1101/191502
1 2019-06-13
2017 Cristina Spalletti, Claudia Alia, Stefano Lai, Alessandro Panarese, Sara Conti, Silvestro Micera, Matteo Caleo
Combining robotic training and inactivation of the healthy hemisphere restores pre-stroke motor patterns in mice
published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.28662
eLife 6 2019-06-13
2018 Pavone, Francesco; Sacconi, Leonardo; Vanzi, Francesco; Gheisari, Ali; Alterini, Tommaso; Di Giovanna, Antonino; Turrini, Lapo; Silvestri, Ludovico; Müllenbroich, Caroline; Costantini, Irene
Increasing sensitivity and accuracy of brain-wide quantitative studies in light-sheet microscopy
published pages: , ISSN: , DOI: 10.1101/230540
1 2019-06-13
2017 Eliana Sammali, Claudia Alia, Gloria Vegliante, Valentina Colombo, Nadia Giordano, Francesca Pischiutta, Giorgio B. Boncoraglio, Mario Barilani, Lorenza Lazzari, Matteo Caleo, Maria-Grazia De Simoni, Giuseppe Gaipa, Giuseppe Citerio, Elisa R. Zanier
Intravenous infusion of human bone marrow mesenchymal stromal cells promotes functional recovery and neuroplasticity after ischemic stroke in mice
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-07274-w
Scientific Reports 7/1 2019-06-13
2018 Alessandro Rizzo, Enrico Domenico Lemma, Filippo Pisano, Marco Pisanello, Leonardo Sileo, Massimo De Vittorio, Ferruccio Pisanello
Laser micromachining of tapered optical fibers for spatially selective control of neural activity
published pages: 88-95, ISSN: 0167-9317, DOI: 10.1016/j.mee.2018.02.010
Microelectronic Engineering 192 2019-06-13
2018 Marco Pisanello, Filippo Pisano, Leonardo Sileo, Emanuela Maglie, Elisa Bellistri, Barbara Spagnolo, Gil Mandelbaum, Bernardo L. Sabatini, Massimo De Vittorio, Ferruccio Pisanello
Tailoring light delivery for optogenetics by modal demultiplexing in tapered optical fibers
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-22790-z
Scientific Reports 8/1 2019-06-13
2017 Costantini, Irene; Müllenbroich, Caroline; Di Giovanna, Antonino; Sacconi, Leonardo; Silvestri, Ludovico; Pavone, Francesco
RAPID: Real-time image-based autofocus for all wide-field optical microscopy systems
published pages: , ISSN: , DOI: 10.1101/170555
1 2019-06-13
2018 Filippo Pisano, Marco Pisanello, Leonardo Sileo, Antonio Qualtieri, Bernardo L. Sabatini, Massimo De Vittorio, Ferruccio Pisanello
Focused ion beam nanomachining of tapered optical fibers for patterned light delivery
published pages: 41-49, ISSN: 0167-9317, DOI: 10.1016/j.mee.2018.03.023
Microelectronic Engineering 195 2019-06-13
2017 Pavone, Francesco; Caleo, Matteo; Micera, Silvestro; Sacconi, Leonardo; Panarese, Alessandro; Quarta, Eros; Conti, Emilia; Mascaro, Anna; Alia, Claudia; Spalletti, Cristina; Di Giovanna, Antonino; Lai, Stefano
Rehabilitation promotes the recovery of functional and structural features of healthy neuronal networks after stoke
published pages: , ISSN: , DOI: 10.1101/141697
1 2019-06-13
2019 Antonino Paolo Di Giovanna, Caterina Credi, Alessandra Franceschini, Marie Caroline Müllenbroich, Ludovico Silvestri, Francesco Saverio Pavone
Tailored Sample Mounting for Light-Sheet Fluorescence Microscopy of Clarified Specimens by Polydimethylsiloxane Casting
published pages: , ISSN: 1662-5129, DOI: 10.3389/fnana.2019.00035
Frontiers in Neuroanatomy 13 2019-08-30
2018 M. Caroline Müllenbroich, Ludovico Silvestri, Antonino P. Di Giovanna, Giacomo Mazzamuto, Irene Costantini, Leonardo Sacconi, Francesco S. Pavone
High-Fidelity Imaging in Brain-Wide Structural Studies Using Light-Sheet Microscopy
published pages: ENEURO.0124-18.2, ISSN: 2373-2822, DOI: 10.1523/eneuro.0124-18.2018
eneuro 5/6 2019-08-30
2018 M. Caroline Müllenbroich, Lapo Turrini, Ludovico Silvestri, Tommaso Alterini, Ali Gheisari, Natascia Tiso, Francesco Vanzi, Leonardo Sacconi, Francesco S. Pavone
Bessel Beam Illumination Reduces Random and Systematic Errors in Quantitative Functional Studies Using Light-Sheet Microscopy
published pages: , ISSN: 1662-5102, DOI: 10.3389/fncel.2018.00315
Frontiers in Cellular Neuroscience 12 2019-08-30
2019 Giuseppe Sancataldo, Vladislav Gavryusev, Giuseppe de Vito, Lapo Turrini, Massimiliano Locatelli, Chiara Fornetto, Natascia Tiso, Francesco Vanzi, Ludovico Silvestri, Francesco Saverio Pavone
Flexible Multi-Beam Light-Sheet Fluorescence Microscope for Live Imaging Without Striping Artifacts
published pages: , ISSN: 1662-5129, DOI: 10.3389/fnana.2019.00007
Frontiers in Neuroanatomy 13 2019-08-30

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