Explore the words cloud of the RAPID project. It provides you a very rough idea of what is the project "RAPID" about.
The following table provides information about the project.
|Coordinator Country||Sweden [SE]|
|Total cost||1˙846˙360 €|
|EC max contribution||1˙846˙360 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2017-01-01 to 2021-12-31|
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|1||KAROLINSKA INSTITUTET||SE (STOCKHOLM)||coordinator||1˙846˙360.00|
Histone proteins provide a dynamic packaging system for the eukaryotic genome. Chromatin integrates a multitude of signals to control gene expression, only some of which have the propensity to be maintained through replication and cell division. For our understanding of cellular memory and epigenetic inheritance we need to know what features characterize a stable, heritable chromatin state throughout the cell cycle. State-of-the-art methods such as ChIP-Seq provide population-based snapshots of the epigenomic landscape but little information on the stability and relative importance of each studied feature or modification. This project pioneers a rapid, sensitive and selective protein labeling method (termed RAPID) for capturing genome-wide chromatin dynamics resolved over a period of time ranging from minutes to days. RAPID introduces a flexible time dimension in the form of pulse or pulse-chase experiments for studying genome-wide occupancy of a protein of interest by next-gen sequencing. It can also be coupled to other readouts such as mass spectrometry or microscopy. RAPID is uniquely suited for studying cell cycle-linked processes, by defining when and where stable ‘marks’ are set in chromatin. I will employ mouse embryonic stem cell (mESC) as a model system for pluripotency and lineage specification. RAPID will define fundamental rules for inheritance of histone and other chromatin-associated proteins and how they are modulated by the fast cell cycle of pluripotent cells. Using RAPID in combination with other state-of-the art genetics and epigenomics, I will collect multi-dimensional descriptions of the dynamic evolution and propagation of functionally relevant chromatin states, such as interstitial heterochromatin and developmentally regulated Polycomb domains.
|year||authors and title||journal||last update|
Birthe Meineke, Johannes HeimgÃ¤rtner, Lorenzo Lafranchi, Simon J ElsÃ¤sser
Methanomethylophilus alvus Mx1201 provides basis for mutual orthogonal pyrrolysyl tRNA/aminoacyl-tRNA synthetase pairs in mammalian cells
published pages: , ISSN: , DOI: 10.1101/371757
Banushree Kumar, Simon J ElsÃ¤sser
Quantitative multiplexed ChIP reveals global alterations that shape promoter bivalency in ground state embryonic stem cells
published pages: , ISSN: , DOI: 10.1101/557082
Birthe Meineke, Johannes HeimgÃ¤rtner, Lorenzo Lafranchi, Simon J. ElsÃ¤sser
Methanomethylophilus alvus Mx1201 Provides Basis for Mutual Orthogonal Pyrrolysyl tRNA/Aminoacyl-tRNA Synthetase Pairs in Mammalian Cells
published pages: 3087-3096, ISSN: 1554-8929, DOI: 10.1021/acschembio.8b00571
|ACS Chemical Biology 13/11||2019-08-29|
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