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MECHANO-CONTROL SIGNED

Mechanical control of biological function

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EC-Contrib. €

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Project "MECHANO-CONTROL" data sheet

The following table provides information about the project.

Coordinator
FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA 

Organization address
address: CARRER BALDIRI REIXAC PLANTA 2A 10-12
city: BARCELONA
postcode: 8028
website: http://www.ibecbarcelona.eu

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Project website http://mechanocontrol.eu/
 Total cost 7˙134˙928 €
 EC max contribution 7˙134˙928 € (100%)
 Programme 1. H2020-EU.1.2.2. (FET Proactive)
 Code Call FETPROACT-2016
 Funding Scheme RIA
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2021-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA ES (BARCELONA) coordinator 1˙952˙419.00
2    UNIVERSITAIR MEDISCH CENTRUM UTRECHT NL (UTRECHT) participant 2˙337˙450.00
3    NOVIOCELL BV NL (OSS) participant 710˙500.00
4    KING'S COLLEGE LONDON UK (LONDON) participant 706˙715.00
5    LEIBNIZ-INSTITUT FUER NEUE MATERIALIEN GEMEINNUETZIGE GMBH DE (SAARBRUECKEN) participant 662˙000.00
6    UNIVERSITAT POLITECNICA DE CATALUNYA ES (BARCELONA) participant 638˙000.00
7    MIND THE BYTE SL ES (BARCELONA) participant 127˙844.00

Map

 Project objective

Mechanical forces transmitted through specific molecular bonds drive biological function, and their understanding and control hold an uncharted potential in oncology, regenerative medicine and biomaterial design. However, this potential has not been realised, because it requires developing and integrating disparate technologies to measure and manipulate mechanical and adhesive properties from the nanometre to the metre scale. We propose to address this challenge by building an interdisciplinary research community with the aim of understanding and controlling cellular mechanics from the molecular to the organism scale. At the nanometric molecular level, we will develop cellular microenvironments enabled by peptidomimetics of cell-cell and cell-matrix ligands, with defined mechanical and adhesive properties that we will dynamically control in time and space trough photo-activation. The properties under force of the molecular bonds involved will be characterized using single-molecule atomic force microscopy and magnetic tweezers. At the cell-to-organ scale, we will combine controlled microenvironments and interfering strategies with the development of techniques to measure and control mechanical forces and adhesion in cells and tissues, and to evaluate their biological response. At the organism scale, we will establish how cellular mechanics can be controlled, by targeting specific adhesive interactions, to impair or abrogate breast tumour progression in a mouse model. At all stages and scales of the project, we will integrate experimental data with multi-scale computational modelling to establish the rules driving biological response to mechanics and adhesion. With this approach, we aim to develop specific therapeutic approaches beyond the current paradigm in breast cancer treatment. Beyond breast cancer, the general principles targeted by our technology will have high applicability in oncology, regenerative medicine and biomaterials.

 Deliverables

List of deliverables.
Summer school Websites, patent fillings, videos etc. 2020-02-19 16:51:09
Updated Plan for the Exploitation and Dissemination of Results M30 Documents, reports 2020-02-19 16:51:09
Set-up of the continuum model coupling adhesion, cortex, membrane and matrix Other 2020-02-19 16:51:09
Characterization of mechanical and adhesive factors driving sub-cellular behaviour Documents, reports 2020-02-19 16:51:09
Set-up of the discrete stochastic models for bond clusters Other 2020-02-19 16:51:07
Updated Plan for the Exploitation and Dissemination of Results M12 Documents, reports 2020-02-19 16:51:07
Logo and Public website of the project Websites, patent fillings, videos etc. 2020-02-19 16:51:07
Plan for the Exploitation and Dissemination of Results Documents, reports 2020-02-19 16:51:07

Take a look to the deliverables list in detail:  detailed list of MECHANO-CONTROL deliverables.

 Publications

year authors and title journal last update
List of publications.
2018 Roshna V. Nair, Aleeza Farrukh, Aránzazu del Campo
A Photoactivatable α 5 β 1 -Specific Integrin Ligand
published pages: 1280-1287, ISSN: 1439-4227, DOI: 10.1002/cbic.201800180
ChemBioChem 19/12 2020-02-19
2018 Heather C. Bruner, Patrick W.B. Derksen
Loss of E-Cadherin-Dependent Cell–Cell Adhesion and the Development and Progression of Cancer
published pages: a029330, ISSN: 1943-0264, DOI: 10.1101/cshperspect.a029330
Cold Spring Harbor Perspectives in Biology 10/3 2020-02-19
2018 Jorge Escribano, Raimon Sunyer, María Teresa Sánchez, Xavier Trepat, Pere Roca-Cusachs, José Manuel García-Aznar
A hybrid computational model for collective cell durotaxis
published pages: 1037-1052, ISSN: 1617-7959, DOI: 10.1007/s10237-018-1010-2
Biomechanics and Modeling in Mechanobiology 17/4 2020-02-19
2019 Aleeza Farrukh, Julieta I. Paez, Aránzazu del Campo
4D Biomaterials for Light‐Guided Angiogenesis
published pages: 1807734, ISSN: 1616-301X, DOI: 10.1002/adfm.201807734
Advanced Functional Materials 29/6 2020-02-19
2018 Aleeza Farrukh, Wenqiang Fan, Shifang Zhao, Marcelo Salierno, Julieta I. Paez, Aránzazu del Campo
Photoactivatable Adhesive Ligands for Light-Guided Neuronal Growth
published pages: 1271-1279, ISSN: 1439-4227, DOI: 10.1002/cbic.201800118
ChemBioChem 19/12 2020-02-19
2018 Ernest Latorre, Sohan Kale, Laura Casares, Manuel Gómez-González, Marina Uroz, Léo Valon, Roshna V. Nair, Elena Garreta, Nuria Montserrat, Aránzazu del Campo, Benoit Ladoux, Marino Arroyo, Xavier Trepat
Active superelasticity in three-dimensional epithelia of controlled shape
published pages: 203-208, ISSN: 0028-0836, DOI: 10.1038/s41586-018-0671-4
Nature 563/7730 2020-02-19
2018 Xavier Trepat, Erik Sahai
Mesoscale physical principles of collective cell organization
published pages: 671-682, ISSN: 1745-2473, DOI: 10.1038/s41567-018-0194-9
Nature Physics 14/7 2020-02-19
2018 Joseph Jose Thottacherry, Anita Joanna Kosmalska, Amit Kumar, Amit Singh Vishen, Alberto Elosegui-Artola, Susav Pradhan, Sumit Sharma, Parvinder P. Singh, Marta C. Guadamillas, Natasha Chaudhary, Ram Vishwakarma, Xavier Trepat, Miguel A. del Pozo, Robert G. Parton, Madan Rao, Pramod Pullarkat, Pere Roca-Cusachs, Satyajit Mayor
Mechanochemical feedback control of dynamin independent endocytosis modulates membrane tension in adherent cells
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-06738-5
Nature Communications 9/1 2020-02-19
2018 Clara R. L. Oudenaarden, Robert A. H. van de Ven, Patrick W. B. Derksen
Re-inforcing the cell death army in the fight against breast cancer
published pages: jcs212563, ISSN: 0021-9533, DOI: 10.1242/jcs.212563
Journal of Cell Science 131/16 2020-02-19
2018 Arthur J. Kuipers, Jeroen Middelbeek, Kirsten Vrenken, Carlos Pérez-González, Geert Poelmans, Jeffrey Klarenbeek, Kees Jalink, Xavier Trepat, Frank N. van Leeuwen
TRPM7 controls mesenchymal features of breast cancer cells by tensional regulation of SOX4
published pages: 2409-2419, ISSN: 0925-4439, DOI: 10.1016/j.bbadis.2018.04.017
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1864/7 2020-02-19
2018 Amy E. M. Beedle, Marc Mora, Colin T. Davis, Ambrosius P. Snijders, Guillaume Stirnemann, Sergi Garcia-Manyes
Forcing the reversibility of a mechanochemical reaction
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-05115-6
Nature Communications 9/1 2020-02-19
2018 Aleeza Farrukh, Shifang Zhao, Julieta I. Paez, Atria Kavyanifar, Marcelo Salierno, Adolfo Cavalié, Aránzazu del Campo
In Situ, Light-Guided Axon Growth on Biomaterials via Photoactivatable Laminin Peptidomimetic IK(HANBP)VAV
published pages: 41129-41137, ISSN: 1944-8244, DOI: 10.1021/acsami.8b15517
ACS Applied Materials & Interfaces 10/48 2020-02-19
2018 Adam Shellard, András Szabó, Xavier Trepat, Roberto Mayor
Supracellular contraction at the rear of neural crest cell groups drives collective chemotaxis
published pages: 339-343, ISSN: 0036-8075, DOI: 10.1126/science.aau3301
Science 362/6412 2020-02-19
2018 Marina Uroz, Sabrina Wistorf, Xavier Serra-Picamal, Vito Conte, Marta Sales-Pardo, Pere Roca-Cusachs, Roger Guimerà, Xavier Trepat
Regulation of cell cycle progression by cell–cell and cell–matrix forces
published pages: 646-654, ISSN: 1465-7392, DOI: 10.1038/s41556-018-0107-2
Nature Cell Biology 20/6 2020-02-19
2018 Yong Jian Wang, Palma Rico-Lastres, Ainhoa Lezamiz, Marc Mora, Carles Solsona, Guillaume Stirnemann, Sergi Garcia-Manyes
DNA Binding Induces a Nanomechanical Switch in the RRM1 Domain of TDP-43
published pages: 3800-3807, ISSN: 1948-7185, DOI: 10.1021/acs.jpclett.8b01494
The Journal of Physical Chemistry Letters 9/14 2020-02-19
2018 Alberto Elosegui-Artola, Xavier Trepat, Pere Roca-Cusachs
Control of Mechanotransduction by Molecular Clutch Dynamics
published pages: 356-367, ISSN: 0962-8924, DOI: 10.1016/j.tcb.2018.01.008
Trends in Cell Biology 28/5 2020-02-19
2018 Nils C Gauthier, Pere Roca-Cusachs
Mechanosensing at integrin-mediated cell–matrix adhesions: from molecular to integrated mechanisms
published pages: 20-26, ISSN: 0955-0674, DOI: 10.1016/j.ceb.2017.12.014
Current Opinion in Cell Biology 50 2020-02-19
2018 Anna Labernadie, Xavier Trepat
Sticking, steering, squeezing and shearing: cell movements driven by heterotypic mechanical forces
published pages: 57-65, ISSN: 0955-0674, DOI: 10.1016/j.ceb.2018.04.008
Current Opinion in Cell Biology 54 2020-02-19
2017 Pere Roca-Cusachs, Vito Conte, Xavier Trepat
Quantifying forces in cell biology
published pages: 742-751, ISSN: 1465-7392, DOI: 10.1038/ncb3564
Nature Cell Biology 19/7 2020-02-19
2017 Anna Labernadie, Takuya Kato, Agustí Brugués, Xavier Serra-Picamal, Stefanie Derzsi, Esther Arwert, Anne Weston, Victor González-Tarragó, Alberto Elosegui-Artola, Lorenzo Albertazzi, Jordi Alcaraz, Pere Roca-Cusachs, Erik Sahai, Xavier Trepat
A mechanically active heterotypic E-cadherin/N-cadherin adhesion enables fibroblasts to drive cancer cell invasion
published pages: 224-237, ISSN: 1465-7392, DOI: 10.1038/ncb3478
Nature Cell Biology 19/3 2020-02-19
2017 Alberto Elosegui-Artola, Pere Roca-Cusachs
Amoebae as Mechanosensitive Tanks
published pages: 2457-2458, ISSN: 0006-3495, DOI: 10.1016/j.bpj.2017.05.020
Biophysical Journal 112/12 2020-02-19
2017 Leire Neri, Marta Lasa, Alberto Elosegui-Artola, Delia D\'Avola, Beatriz Carte, Cristina Gazquez, Sara Alve, Pere Roca-Cusachs, Mercedes Iñarrairaegui, Jose Herrero, Jesús Prieto, Bruno Sangro, Rafael Aldabe
\"NatB-mediated protein N-α-terminal acetylation is a potential therapeutic target in hepatocellular carcinoma\"
published pages: , ISSN: 1949-2553, DOI: 10.18632/oncotarget.17332
Oncotarget 8/25 2020-02-19
2018 Mark Bennett, Marco Cantini, Julien Reboud, Jonathan M. Cooper, Pere Roca-Cusachs, Manuel Salmeron-Sanchez
Molecular clutch drives cell response to surface viscosity
published pages: 1192-1197, ISSN: 0027-8424, DOI: 10.1073/pnas.1710653115
Proceedings of the National Academy of Sciences 115/6 2020-02-19
2017 Roger Oria, Tina Wiegand, Jorge Escribano, Alberto Elosegui-Artola, Juan Jose Uriarte, Cristian Moreno-Pulido, Ilia Platzman, Pietro Delcanale, Lorenzo Albertazzi, Daniel Navajas, Xavier Trepat, José Manuel García-Aznar, Elisabetta Ada Cavalcanti-Adam, Pere Roca-Cusachs
Force loading explains spatial sensing of ligands by cells
published pages: , ISSN: 0028-0836, DOI: 10.1038/nature24662
Nature 2020-02-19
2017 Pilar Rodríguez-Franco, Agustí Brugués, Ariadna Marín-Llauradó, Vito Conte, Guiomar Solanas, Eduard Batlle, Jeffrey J. Fredberg, Pere Roca-Cusachs, Raimon Sunyer, Xavier Trepat
Long-lived force patterns and deformation waves at repulsive epithelial boundaries
published pages: 1029-1037, ISSN: 1476-1122, DOI: 10.1038/NMAT4972
Nature Materials 16/10 2020-02-19
2017 Víctor González-Tarragó, Alberto Elosegui-Artola, Elsa Bazellières, Roger Oria, Carlos Pérez-González, Pere Roca-Cusachs
Binding of ZO-1 to α5β1 integrins regulates the mechanical properties of α5β1–fibronectin links
published pages: 1847-1852, ISSN: 1059-1524, DOI: 10.1091/mbc.E17-01-0006
Molecular Biology of the Cell 28/14 2020-02-19
2017 Bruno Pontes, Pascale Monzo, Laurent Gole, Anabel-Lise Le Roux, Anita Joanna Kosmalska, Zhi Yang Tam, Weiwei Luo, Sophie Kan, Virgile Viasnoff, Pere Roca-Cusachs, Lisa Tucker-Kellogg, Nils C. Gauthier
Membrane tension controls adhesion positioning at the leading edge of cells
published pages: jcb.201611117, ISSN: 0021-9525, DOI: 10.1083/jcb.201611117
The Journal of Cell Biology 2020-02-19
2017 Alberto Elosegui-Artola, Ion Andreu, Amy E.M. Beedle, Ainhoa Lezamiz, Marina Uroz, Anita J. Kosmalska, Roger Oria, Jenny Z. Kechagia, Palma Rico-Lastres, Anabel-Lise Le Roux, Catherine M. Shanahan, Xavier Trepat, Daniel Navajas, Sergi Garcia-Manyes, Pere Roca-Cusachs
Force Triggers YAP Nuclear Entry by Regulating Transport across Nuclear Pores
published pages: 1397-1410.e14, ISSN: 0092-8674, DOI: 10.1016/j.cell.2017.10.008
Cell 171/6 2020-02-19
2018 Judit Perales-Calvo, David Giganti, Guillaume Stirnemann, Sergi Garcia-Manyes
The force-dependent mechanism of DnaK-mediated mechanical folding
published pages: eaaq0243, ISSN: 2375-2548, DOI: 10.1126/sciadv.aaq0243
Science Advances 4/2 2020-02-19
2019 Seyedeh Atefeh Mobasseri, Sebastiaan Zijl, Vasiliki Salameti, Gernot Walko, Andrew Stannard, Sergi Garcia-Manyes, Fiona M. Watt
Patterning of human epidermal stem cells on undulating elastomer substrates reflects differences in cell stiffness
published pages: 256-264, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2019.01.063
Acta Biomaterialia 87 2020-02-19
2019 Anabel-Lise Le Roux, Xarxa Quiroga, Nikhil Walani, Marino Arroyo, Pere Roca-Cusachs
The plasma membrane as a mechanochemical transducer
published pages: 20180221, ISSN: 0962-8436, DOI: 10.1098/rstb.2018.0221
Philosophical Transactions of the Royal Society B: Biological Sciences 374/1779 2020-02-19
2019 Jenny Z. Kechagia, Johanna Ivaska, Pere Roca-Cusachs
Integrins as biomechanical sensors of the microenvironment
published pages: 457-473, ISSN: 1471-0072, DOI: 10.1038/s41580-019-0134-2
Nature Reviews Molecular Cell Biology 20/8 2020-02-19
2019 Antoine A. Khalil, Johan de Rooij
Cadherin mechanotransduction in leader-follower cell specification during collective migration
published pages: 86-91, ISSN: 0014-4827, DOI: 10.1016/j.yexcr.2019.01.006
Experimental Cell Research 376/1 2020-02-19
2019 Elvira Infante, Andrew Stannard, Stephanie J. Board, Palma Rico-Lastres, Elena Rostkova, Amy E. M. Beedle, Ainhoa Lezamiz, Yong Jian Wang, Samuel Gulaidi Breen, Fani Panagaki, Vinoth Sundar Rajan, Catherine Shanahan, Pere Roca-Cusachs, Sergi Garcia-Manyes
The mechanical stability of proteins regulates their translocation rate into the cell nucleus
published pages: , ISSN: 1745-2473, DOI: 10.1038/s41567-019-0551-3
Nature Physics 2020-02-19
2019 Marina Uroz, Anna Garcia-Puig, Isil Tekeli, Alberto Elosegui-Artola, Juan F. Abenza, Ariadna Marín-Llauradó, Silvia Pujals, Vito Conte, Lorenzo Albertazzi, Pere Roca-Cusachs, Ángel Raya, Xavier Trepat
Traction forces at the cytokinetic ring regulate cell division and polyploidy in the migrating zebrafish epicardium
published pages: , ISSN: 1476-1122, DOI: 10.1038/s41563-019-0381-9
Nature Materials 2020-02-19
2019 Elena Garreta, Patricia Prado, Carolina Tarantino, Roger Oria, Lucia Fanlo, Elisa Martí, Dobryna Zalvidea, Xavier Trepat, Pere Roca-Cusachs, Aleix Gavaldà-Navarro, Luca Cozzuto, Josep M. Campistol, Juan Carlos Izpisúa Belmonte, Carmen Hurtado del Pozo, Nuria Montserrat
Fine tuning the extracellular environment accelerates the derivation of kidney organoids from human pluripotent stem cells
published pages: 397-405, ISSN: 1476-1122, DOI: 10.1038/s41563-019-0287-6
Nature Materials 18/4 2020-02-19
2019 Essak S. Khan, Shrikrishnan Sankaran, Julieta I. Paez, Christina Muth, Mitchell K. L. Han, Aránzazu del Campo
Photoactivatable Hsp47: A Tool to Regulate Collagen Secretion and Assembly
published pages: 1801982, ISSN: 2198-3844, DOI: 10.1002/advs.201801982
Advanced Science 6/9 2020-02-19

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