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INSTRUCT-ULTRA SIGNED

Releasing the full potential of Instruct to expand and consolidate infrastructure services for integrated structural life science research

Total Cost €

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EC-Contrib. €

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Partnership

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Project "INSTRUCT-ULTRA" data sheet

The following table provides information about the project.

Coordinator
INSTRUCT ACADEMIC SERVICES LIMITED 

Organization address
address: UNIVERSITY OF OXFORD OFFICES WELLINGTON SQUARE
city: OXFORD
postcode: OX1 2JD
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://www.instruct-ultra.eu
 Total cost 3˙950˙000 €
 EC max contribution 3˙950˙000 € (100%)
 Programme 1. H2020-EU.1.4.1.1. (Developing new world-class research infrastructures)
 Code Call H2020-INFRADEV-2016-1
 Funding Scheme CSA
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2020-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTRUCT ACADEMIC SERVICES LIMITED UK (OXFORD) coordinator 419˙088.00
2    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UK (OXFORD) participant 928˙208.00
3    CONSORZIO INTERUNIVERSITARIO RISONANZE MAGNETICHE DI METALLO PROTEINE IT (FIRENZE) participant 440˙000.00
4    UNIVERSITEIT UTRECHT NL (UTRECHT) participant 390˙000.00
5    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) participant 357˙000.00
6    AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS ES (MADRID) participant 207˙450.00
7    Masarykova univerzita CZ (BRNO STRED) participant 200˙000.00
8    JOHANN WOLFGANG GOETHE-UNIVERSITATFRANKFURT AM MAIN DE (FRANKFURT AM MAIN) participant 160˙252.00
9    VIB VZW BE (ZWIJNAARDE - GENT) participant 138˙000.00
10    KAROLINSKA INSTITUTET SE (STOCKHOLM) participant 110˙000.00
11    AARHUS UNIVERSITET DK (AARHUS C) participant 100˙000.00
12    CHEMICKY USTAV SLOVENSKEJ AKADEMIEVIED SK (BRATISLAVA) participant 100˙000.00
13    ETHNIKO IDRYMA EREVNON EL (ATHINA) participant 100˙000.00
14    OULUN YLIOPISTO FI (OULU) participant 100˙000.00
15    UNIVERSIDADE NOVA DE LISBOA PT (LISBOA) participant 100˙000.00
16    WEIZMANN INSTITUTE OF SCIENCE IL (REHOVOT) participant 100˙000.00
17    INSTITUTO DE TECNOLOGIA QUIMICA E BIOLOGICA - UNIVERSIDADE NOVA DE LISBOA PT (OEIRAS) participant 0.00

Map

 Project objective

Instruct-Ultra aims to advance the scope and efficiency of implementation of Instruct and consolidate the foundations for long-term sustainability. This will be achieved through specific objectives: expand Instruct membership to new Member States and increase global links; engage new user communities; improve efficiencies in service delivery; improve data capture and management; adjust the scale and reliability of the infrastructure. Instruct-Ultra will deliver these alongside the transition to ERIC legal status and rapid developments in, and increased demand for, integrated structural biology infrastructure. These advances in the scale and speed of delivery will earn further trust within the life science community. One focus will to expand membership to Eastern European states and EFTA countries, integrating their structural biology communities into Instruct and providing new opportunities to support research excellence and raise standards. Opportunities for engaging with industrialised and developing countries outside the ERA will build on existing cooperative work between Instruct and Asian, African and South American countries to establish strong bilateral programmes of benefit to both parties, giving Instruct better engagement in emerging global challenges and positioning Instruct as a trusted global resource for high quality structural biology services. Starting from baseline operations four years ago Instruct has now identified key areas of service which should be expanded, new potential user groups, and opportunities for more reliable, efficient and sometimes remotely used workflows. Instruct-Ultra will therefore test new modes of access and pilot new service methods in high demand areas to accelerate access for more users. Instruct-Ultra will reinforce Instruct operations by updating and expanding the business plan and structural biology roadmap, whilst improving the interface with academia and industry as a strategy to sustainability.

 Deliverables

List of deliverables.
Outreach programme for new academic communities including an information pack Websites, patent fillings, videos etc. 2019-06-05 14:49:45
Publication of a position paper on the operation of NMR services and RIs in general as a guide for users in collaboration with WP3 Documents, reports 2019-06-05 14:49:45
Process for establishing joint activities with new countries and formalising an agreement defining the shared programme Documents, reports 2019-06-05 14:49:45
Plan a programme for review of Instruct infrastructure with external review panel Documents, reports 2019-06-05 14:49:45
Dissemination, outreach and exploitation plan submitted to Executive Committee for review Documents, reports 2019-06-05 14:49:45
Call 1 launched for developing new service provision of existing technologies and selection of qualifying projects Other 2019-06-05 14:49:45

Take a look to the deliverables list in detail:  detailed list of INSTRUCT-ULTRA deliverables.

 Publications

year authors and title journal last update
List of publications.
2020 Antonio Schirò, Azzurra Carlon, Giacomo Parigi, Garib Murshudov, Vito Calderone, Enrico Ravera, Claudio Luchinat
On the complementarity of X-ray and NMR data
published pages: 100019, ISSN: 2590-1524, DOI: 10.1016/j.yjsbx.2020.100019
Journal of Structural Biology: X 4 2020-03-05
2019 Leonid Andronov, Khalid Ouararhni, Isabelle Stoll, Bruno P. Klaholz, Ali Hamiche
CENP-A nucleosome clusters form rosette-like structures around HJURP during G1
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-12383-3
Nature Communications 10/1 2020-03-05
2019 Erney Ramírez-Aportela, Javier Mota, Pablo Conesa, Jose Maria Carazo, Carlos Oscar S. Sorzano
DeepRes : a new deep-learning- and aspect-based local resolution method for electron-microscopy maps
published pages: 1054-1063, ISSN: 2052-2525, DOI: 10.1107/s2052252519011692
IUCrJ 6/6 2020-03-05
2019 Uchanski T, Masiulis S, Fischer B, Kalichuk V, Wohlkonig A, Zogg T, Remaut H, Vranken W, Aricescu AR, Pardon E, Steyaert J.
Megabodies expand the nanobody toolkit for protein structure determination by single-particle cryo-EM.
published pages: , ISSN: , DOI:
bioRxiv 2020-03-05
2019 Bruno P. Klaholz
Deriving and refining atomic models in crystallography and cryo-EM: the latest Phenix tools to facilitate structure analysis
published pages: 878-881, ISSN: 2059-7983, DOI: 10.1107/s2059798319013391
Acta Crystallographica Section D Structural Biology 75/10 2020-03-05
2019 Sanchez-Garcia R, Segura J, Maluenda D, Sorzano CO, Carazo JM.
MicrographCleaner: a python package for cryo-EM micrograph segmentation using deep learning.
published pages: , ISSN: , DOI:
bioRxiv 2020-03-05
2018 Maryam Faridounnia, Gert Folkers, Rolf Boelens
Function and Interactions of ERCC1-XPF in DNA Damage Response
published pages: 3205, ISSN: 1420-3049, DOI: 10.3390/molecules23123205
Molecules 23/12 2020-03-05
2018 Amaya Jiménez, Slavica Jonic, Tomas Majtner, Joaquín Otón, Jose Luis Vilas, David Maluenda, Javier Mota, Erney Ramírez-Aportela, Marta Martínez, Yaiza Rancel, Joan Segura, Ruben Sánchez-García, Roberto Melero, Laura del Cano, Pablo Conesa, Lars Skjaerven, Roberto Marabini, Jose M Carazo, Carlos Oscar S Sorzano
Validation of electron microscopy initial models via small angle X-ray scattering curves
published pages: 2427-2433, ISSN: 1367-4803, DOI: 10.1093/bioinformatics/bty985
Bioinformatics 35/14 2020-03-05
2019 Haitian Fan, Alexander P. Walker, Loïc Carrique, Jeremy R. Keown, Itziar Serna Martin, Dimple Karia, Jane Sharps, Narin Hengrung, Els Pardon, Jan Steyaert, Jonathan M. Grimes, Ervin Fodor
Structures of influenza A virus RNA polymerase offer insight into viral genome replication
published pages: 287-290, ISSN: 0028-0836, DOI: 10.1038/s41586-019-1530-7
Nature 573/7773 2020-03-05
2019 Linda Cerofolini, Stefano Giuntini, Letizia Barbieri, Matteo Pennestri, Anna Codina, Marco Fragai, Lucia Banci, Enrico Luchinat, Enrico Ravera
Real-Time Insights into Biological Events: In-Cell Processes and Protein-Ligand Interactions
published pages: 239-247, ISSN: 0006-3495, DOI: 10.1016/j.bpj.2018.11.3132
Biophysical Journal 116/2 2020-03-05
2019 D. Maluenda, T. Majtner, P. Horvath, J. L. Vilas, A. Jiménez-Moreno, J. Mota, E. Ramírez-Aportela, R. Sánchez-García, P. Conesa, L. del Caño, Y. Rancel, Y. Fonseca, M. Martínez, G. Sharov, C.A. García, D. Strelak, R. Melero, R. Marabini, J. M. Carazo, C. O. S. Sorzano
Flexible workflows for on-the-fly electron-microscopy single-particle image processing using Scipion
published pages: 882-894, ISSN: 2059-7983, DOI: 10.1107/s2059798319011860
Acta Crystallographica Section D Structural Biology 75/10 2020-03-05
2019 Tomasz Uchański, Simonas Masiulis, Baptiste Fischer, Valentina Kalichuk, Alexandre Wohlkönig, Thomas Zögg, Han Remaut, Wim Vranken, A. Radu Aricescu, Els Pardon, Jan Steyaert
Megabodies expand the nanobody toolkit for protein structure determination by single-particle cryo-EM
published pages: , ISSN: , DOI: 10.1101/812230
bioRxiv 2020-02-06
2018 Ottilie von Loeffelholz, Gabor Papai, Radostin Danev, Alexander G. Myasnikov, S. Kundhavai Natchiar, Isabelle Hazemann, Jean-François Ménétret, Bruno P. Klaholz
Volta phase plate data collection facilitates image processing and cryo-EM structure determination
published pages: 191-199, ISSN: 1047-8477, DOI: 10.1016/j.jsb.2018.01.003
Journal of Structural Biology 202/3 2019-06-12
2017 S. Kundhavai Natchiar, Alexander G. Myasnikov, Hanna Kratzat, Isabelle Hazemann, Bruno P. Klaholz
Visualization of chemical modifications in the human 80S ribosome structure
published pages: , ISSN: 0028-0836, DOI: 10.1038/nature24482
Nature 2019-06-12
2018 Thomas Vosegaard
Fast simulations of multidimensional NMR spectra of proteins and peptides
published pages: 438-448, ISSN: 0749-1581, DOI: 10.1002/mrc.4663
Magnetic Resonance in Chemistry 56/6 2019-06-12

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