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ULTRACHIRAL SIGNED

Ultrasensitive chiral detection by signal-reversing cavity polarimetry: applications to in-situ proteomics, single-molecule chirality, HPLC analysis, medical diagnostics, and atmospheric studies

Total Cost €

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EC-Contrib. €

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Partnership

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 ULTRACHIRAL project word cloud

Explore the words cloud of the ULTRACHIRAL project. It provides you a very rough idea of what is the project "ULTRACHIRAL" about.

chirality    medicine    advantages    ccp    signals    single    detection    chiral    sensing    molecule    cavity    industries    chiroptical    polarimetry    pharmaceutical    chemical   

Project "ULTRACHIRAL" data sheet

The following table provides information about the project.

Coordinator
FOUNDATION FOR RESEARCH AND TECHNOLOGY HELLAS 

Organization address
address: N PLASTIRA STR 100
city: HERAKLION
postcode: 70013
website: www.forth.gr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Greece [EL]
 Total cost 3˙999˙250 €
 EC max contribution 3˙999˙250 € (100%)
 Programme 1. H2020-EU.1.2.1. (FET Open)
 Code Call H2020-FETOPEN-1-2016-2017
 Funding Scheme /RIA
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2020-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FOUNDATION FOR RESEARCH AND TECHNOLOGY HELLAS EL (HERAKLION) coordinator 722˙500.00
2    THE UNIVERSITY OF EXETER UK (EXETER) participant 572˙000.00
3    ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE CH (LAUSANNE) participant 567˙500.00
4    PANEPISTIMIO KRITIS EL (RETHIMNO) participant 544˙750.00
5    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UK (OXFORD) participant 535˙000.00
6    JOHANNES GUTENBERG-UNIVERSITAT MAINZ DE (MAINZ) participant 501˙250.00
7    PHOTEK LIMITED UK (EAST SUSSEX) participant 318˙750.00
8    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) participant 237˙500.00

Mappa

 Project objective

Chirality is a fundamental property of life, making chiral sensing and analysis crucial to numerous scientific subfields of biology, chemistry, and medicine, and to the pharmaceutical, chemical, cosmetic, and food industries, constituting a market of 10s of billion €, and growing. Despite the tremendous importance of chiral sensing, its application remains very limited, as chiroptical signals are typically very weak, preventing important biological and medical applications. Recently, the project-coordinating FORTH team has introduced a new form of Chiral-Cavity-based Polarimetry (CCP) for chiral sensing, which has three groundbreaking advantages compared to commercial instruments: (a) The chiroptical signals are enhanced by the number of cavity passes (typically ~1000); (b) otherwise limiting birefringent backgrounds are suppressed; (c) rapid signal reversals give absolute polarimetry measurements, not requiring sample removal for a null-sample measurement. Together, these advantages allow improvement in chiral detection sensitivity by 3-6 orders of magnitude (depending on instrument complexity and price). ULTRACHIRAL aims to revolutionize existing applications of chiral sensing, but also to instigate important new domains which require sensitivities beyond current limits, including: (1) measuring protein structure in-situ, in solution, at surfaces, and within cells and membranes, thus realizing the “holy-grail” of proteomics; (2) coupling to high performance liquid chromatography (HPLC) for chiral identification of the components of complex mixtures, creating new standards for the pharmaceutical and chemical analysis industries; (3) chiral analysis of human bodily fluids as a diagnostic tool in medicine; (4) measurement of single-molecule chirality, by adapting CCP to microresonators, which have already demonstrated single-molecule detection; and (5) real-time chiral monitoring of terpene emissions from individual trees and forests, as a probe of forest ecology.

 Work performed, outcomes and results:  advancements report(s) 

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