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ULTRACHIRAL SIGNED

Ultrasensitive chiral detection by signal-reversing cavity polarimetry: applications to in-situ proteomics, single-molecule chirality, HPLC analysis, medical diagnostics, and atmospheric studies

Total Cost €

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EC-Contrib. €

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Partnership

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 ULTRACHIRAL project word cloud

Explore the words cloud of the ULTRACHIRAL project. It provides you a very rough idea of what is the project "ULTRACHIRAL" about.

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Project "ULTRACHIRAL" data sheet

The following table provides information about the project.

Coordinator
IDRYMA TECHNOLOGIAS KAI EREVNAS 

Organization address
address: N PLASTIRA STR 100
city: IRAKLEIO
postcode: 70013
website: www.forth.gr

contact info
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surname: n.a.
function: n.a.
email: n.a.
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 Coordinator Country Greece [EL]
 Project website http://ultrachiral.iesl.forth.gr
 Total cost 3˙999˙250 €
 EC max contribution 3˙999˙250 € (100%)
 Programme 1. H2020-EU.1.2.1. (FET Open)
 Code Call H2020-FETOPEN-1-2016-2017
 Funding Scheme RIA
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2020-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    IDRYMA TECHNOLOGIAS KAI EREVNAS EL (IRAKLEIO) coordinator 722˙500.00
2    THE UNIVERSITY OF EXETER UK (EXETER) participant 572˙000.00
3    ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE CH (LAUSANNE) participant 567˙500.00
4    PANEPISTIMIO KRITIS EL (RETHIMNO) participant 544˙750.00
5    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UK (OXFORD) participant 535˙000.00
6    JOHANNES GUTENBERG-UNIVERSITAT MAINZ DE (MAINZ) participant 501˙250.00
7    PHOTEK LIMITED UK (EAST SUSSEX) participant 318˙750.00
8    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) participant 237˙500.00

Map

 Project objective

Chirality is a fundamental property of life, making chiral sensing and analysis crucial to numerous scientific subfields of biology, chemistry, and medicine, and to the pharmaceutical, chemical, cosmetic, and food industries, constituting a market of 10s of billion €, and growing. Despite the tremendous importance of chiral sensing, its application remains very limited, as chiroptical signals are typically very weak, preventing important biological and medical applications. Recently, the project-coordinating FORTH team has introduced a new form of Chiral-Cavity-based Polarimetry (CCP) for chiral sensing, which has three groundbreaking advantages compared to commercial instruments: (a) The chiroptical signals are enhanced by the number of cavity passes (typically ~1000); (b) otherwise limiting birefringent backgrounds are suppressed; (c) rapid signal reversals give absolute polarimetry measurements, not requiring sample removal for a null-sample measurement. Together, these advantages allow improvement in chiral detection sensitivity by 3-6 orders of magnitude (depending on instrument complexity and price). ULTRACHIRAL aims to revolutionize existing applications of chiral sensing, but also to instigate important new domains which require sensitivities beyond current limits, including: (1) measuring protein structure in-situ, in solution, at surfaces, and within cells and membranes, thus realizing the “holy-grail” of proteomics; (2) coupling to high performance liquid chromatography (HPLC) for chiral identification of the components of complex mixtures, creating new standards for the pharmaceutical and chemical analysis industries; (3) chiral analysis of human bodily fluids as a diagnostic tool in medicine; (4) measurement of single-molecule chirality, by adapting CCP to microresonators, which have already demonstrated single-molecule detection; and (5) real-time chiral monitoring of terpene emissions from individual trees and forests, as a probe of forest ecology.

 Deliverables

List of deliverables.
Year 1 progress report Documents, reports 2019-08-07 12:34:10
Social networks integration Websites, patent fillings, videos etc. 2019-08-07 12:34:10
Project website Websites, patent fillings, videos etc. 2019-08-07 12:34:10
Data Management Plan Open Research Data Pilot 2019-08-07 12:34:10
Kick-off meeting report Documents, reports 2019-08-07 12:34:10

Take a look to the deliverables list in detail:  detailed list of ULTRACHIRAL deliverables.

 Publications

year authors and title journal last update
List of publications.
2018 A. J. Geddes, L. V. Skripnikov, A. Borschevsky, J. C. Berengut, V. V. Flambaum, T. P. Rakitzis
Enhanced nuclear-spin-dependent parity-violation effects using the HgH 199 molecule
published pages: , ISSN: 2469-9926, DOI: 10.1103/physreva.98.022508
Physical Review A 98/2 2020-03-05
2019 Ershad Mohammadi, Ahad Tavakoli, Parisa Dehkhoda, Yasaman Jahani, Kosmas L. Tsakmakidis, Andreas Tittl, Hatice Altug
Accessible Superchiral Near-Fields Driven by Tailored Electric and Magnetic Resonances in All-Dielectric Nanostructures
published pages: 1939-1946, ISSN: 2330-4022, DOI: 10.1021/acsphotonics.8b01767
ACS Photonics 6/8 2020-03-05
2019 Michele Gianella, Sioned A. Press, Katherine M. Manfred, Helen C. Norman, Meez Islam, Grant A. D. Ritchie
Sensitive detection of HO 2 radicals produced in an atmospheric pressure plasma using Faraday rotation cavity ring-down spectroscopy
published pages: 124202, ISSN: 0021-9606, DOI: 10.1063/1.5119191
The Journal of Chemical Physics 151/12 2020-03-05
2019 Sotiris Droulias, Lykourgos Bougas
Surface Plasmon Platform for Angle-Resolved Chiral Sensing
published pages: 1485-1492, ISSN: 2330-4022, DOI: 10.1021/acsphotonics.9b00137
ACS Photonics 6/6 2020-03-05
2019 Filiz Yesilkoy, Eduardo R. Arvelo, Yasaman Jahani, Mingkai Liu, Andreas Tittl, Volkan Cevher, Yuri Kivshar, Hatice Altug
Ultrasensitive hyperspectral imaging and biodetection enabled by dielectric metasurfaces
published pages: 390-396, ISSN: 1749-4885, DOI: 10.1038/s41566-019-0394-6
Nature Photonics 13/6 2020-03-05
2019 K. L. Tsakmakidis, O. Reshef, E. Almpanis, G. P. Zouros, E. Mohammadi, D. Saadat, F. Sohrabi, N. Fahimi-Kashani, D. Etezadi, R. W. Boyd, H. Altug
Ultrabroadband 3D invisibility with fast-light cloaks
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-12813-2
Nature Communications 10/1 2020-03-05
2019 Oleg Tretiak, Peter Blümler, Lykourgos Bougas
Variable single-axis magnetic-field generator using permanent magnets
published pages: 115312, ISSN: 2158-3226, DOI: 10.1063/1.5130896
AIP Advances 9/11 2020-03-05
2019 Sotiris Droulias, Ioannis Katsantonis, Maria Kafesaki, Costas M. Soukoulis, Eleftherios N. Economou
Chiral Metamaterials with P T Symmetry and Beyond
published pages: , ISSN: 0031-9007, DOI: 10.1103/physrevlett.122.213201
Physical Review Letters 122/21 2020-03-05
2019 Georgios E Katsoprinakis, T Peter Rakitzis
Cavity-based chiral polarimetry: parity nonconserving optical rotation in Cs, Dy, and HgH
published pages: 213501, ISSN: 0953-4075, DOI: 10.1088/1361-6455/ab410b
Journal of Physics B: Atomic, Molecular and Optical Physics 52/21 2020-03-05
2019 Michael Staudt, Joseph Byron, Karim Piquemal, Jonathan Williams
Compartment specific chiral pinene emissions identified in a Maritime pine forest
published pages: 1158-1166, ISSN: 0048-9697, DOI: 10.1016/j.scitotenv.2018.11.146
Science of The Total Environment 654 2020-03-05
2019 Sotiris Droulias, Ioannis Katsantonis, Maria Kafesaki, Costas M. Soukoulis, Eleftherios N. Economou
Accessible phases via wave impedance engineering with PT -symmetric metamaterials
published pages: , ISSN: 2469-9950, DOI: 10.1103/physrevb.100.205133
Physical Review B 100/20 2020-03-05
2018 Andreas Tittl, Aleksandrs Leitis, Mingkai Liu, Filiz Yesilkoy, Duk-Yong Choi, Dragomir N. Neshev, Yuri S. Kivshar, Hatice Altug
Imaging-based molecular barcoding with pixelated dielectric metasurfaces
published pages: 1105-1109, ISSN: 0036-8075, DOI: 10.1126/science.aas9768
Science 360/6393 2019-08-07
2018 Daniel Rodrigo, Andreas Tittl, Nadine Ait-Bouziad, Aurelian John-Herpin, Odeta Limaj, Christopher Kelly, Daehan Yoo, Nathan J. Wittenberg, Sang-Hyun Oh, Hilal A. Lashuel, Hatice Altug
Resolving molecule-specific information in dynamic lipid membrane processes with multi-resonant infrared metasurfaces
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-04594-x
Nature Communications 9/1 2019-08-07
2018 Dordaneh Etezadi, John B. Warner, Hilal A. Lashuel, Hatice Altug
Real-Time In Situ Secondary Structure Analysis of Protein Monolayer with Mid-Infrared Plasmonic Nanoantennas
published pages: 1109-1117, ISSN: 2379-3694, DOI: 10.1021/acssensors.8b00115
ACS Sensors 3/6 2019-08-07

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