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Curtana

Patented small molecule therapeutics that target cancer stem cells for the treatment of glioblastoma and other brain cancers

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 Curtana project word cloud

Explore the words cloud of the Curtana project. It provides you a very rough idea of what is the project "Curtana" about.

inhibiting    transcription    cure    malignant    patients    therapeutic    biggest    endometrial    45    die       standard    answer    conventional    little    kills    drug    ineffective    80    feasibility    improvement    index    care    radiosensitiser    gliomas    glioblastoma    diagnosed    offers    primary    expansion    aggressive    deadliest    brain    ct    13    drive    therapies    too    trials    tolerated    median    255    cells    identification    cytotoxic    reduce    curtana    marketing    over    blood    progression    tumours    bioavailable    stem    rate    barrier    central    indicate    relative    compound    people    found    179    tumorigenesis    most    diagnoses    approval    molecule    centre    ovarian    hope    investors    killer    instrumental    bulk    months    68    nervous    cancers    tumour    14    drugs    treatment    expressed    orally    small    survival    lung    crosses    rates    worldwide    cancer    killing    potent    benefit    clinical    accounting    olig2   

Project "Curtana" data sheet

The following table provides information about the project.

Coordinator
CURTANA PHARMA LTD 

Organization address
address: 72 GREAT SUFFOLK STREET
city: LONDON
postcode: SE1 0BL
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://www.curtanapharma.com/
 Total cost 71˙429 €
 EC max contribution 50˙000 € (70%)
 Programme 1. H2020-EU.3.1.3. (Treating and managing disease)
 Code Call H2020-SMEINST-1-2016-2017
 Funding Scheme SME-1
 Starting year 2017
 Duration (year-month-day) from 2017-02-01   to  2017-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CURTANA PHARMA LTD UK (LONDON) coordinator 50˙000.00

Map

 Project objective

Over 45,000 people die each year in Europe – and 255,000 worldwide – from cancers of the brain and central nervous system. Gliomas are the biggest killer, accounting for a third of all diagnoses and 80% of primary malignant brain tumours. Among these glioblastoma is the most common, most aggressive and deadliest. Standard of care treatment offers little hope for patients diagnosed with gliomas: there is no cure, the median survival is 14.6 months and the 2-year survival rate is 13.5%. Conventional therapies can reduce tumour bulk, but they are ineffective at killing the cancer stem cells that drive tumour progression. Curtana may have found the answer. Its novel approach targets a transcription factor, Olig2, which is instrumental in tumorigenesis, tumour expansion and survival. By inhibiting Olig2, Curtana’s small molecule compound, CT-179, kills cancer stem cells. Pre-clinical results show CT-179 to be cytotoxic in selected tumours, a potent radiosensitiser, orally bioavailable and well tolerated; it also crosses the blood-brain barrier and has a high therapeutic index relative to conventional cancer drugs. Most importantly, it increases survival rates (in early studies, median improvement was 68%). Results indicate it may have benefit for other cancers too – any in which Olig2 is highly expressed, including all gliomas and other cancers such as lung, ovarian and endometrial. The Phase 1 project will address the feasibility of carrying out the further pre-clinical and clinical studies required before Curtana can apply for drug marketing approval. This will include identification of clinical partners for multi-centre trials that would be carried out in Europe in Phase 2, as well as potential investors.

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The information about "CURTANA" are provided by the European Opendata Portal: CORDIS opendata.

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