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BRECASTEM SIGNED

Functional and Molecular Characterisation of Breast Cancer Stem Cells

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EC-Contrib. €

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Partnership

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 Outcomes and results

 BRECASTEM project word cloud

Explore the words cloud of the BRECASTEM project. It provides you a very rough idea of what is the project "BRECASTEM" about.

differences    heterogeneous    containing    consisting    morphology    surface    luminal    ultimate    self    characterise    caused    cancers    mammary    function    murine    injury    carcinogenesis    regenerate    play    tissue    deregulation    strategies    hierarchy    aggressiveness    functional    cancer    observations    population    remodelling    unipotent    eliminate    leucine    maintenance    types    molecular    coupled    cscs    breast    dramatically    harbour    mutations    lgr6    mechanisms    harbours    cell    occurring    tumour    stem    transformed    postnatally    incompletely    proliferative    adult    rare    pivotal    positive    differentiation    organ    lineage    puberty    replication    driving    depletion    event    impaired    laboratory    gland    plasticity    contributed    host    conversely    progenitors    oncogenic    undergoes    protein    mouse    phenotypically    every    underlying    renewal    therapeutic    pregnancy    repeat    characterisation    tumours    progenitor    give    cellular    unknown    capacities    transforming    receptor    extensive    regeneration    homeostasis    cells    led    identities   

Project "BRECASTEM" data sheet

The following table provides information about the project.

Coordinator		 THE FRANCIS CRICK INSTITUTE LIMITED 

Organization address
address: 1 MIDLAND ROAD
city: LONDON
postcode: NW1 1AT
website: www.crick.ac.uk

contact info
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 Coordinator Country United Kingdom [UK]
 Project website https://www.crick.ac.uk/research/labs/axel-behrens/areas-of-interest/lgr6-marks-a-cancerstem- cell-population-of-luminal-breast-cancer
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-03-01   to  2019-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE FRANCIS CRICK INSTITUTE LIMITED UK (LONDON) coordinator 183˙454.00

Map

 Project objective

Every organ harbours adult stem cells which have the potential for long-term replication, together with the capacities of self-renewal and multi-lineage differentiation. These stem cells function in tissue homeostasis and contribute to regeneration in response to injury. In addition, many cancers are caused by transforming mutations occurring in tissue-specific progenitor cells. These transformed stem cells harbour long-term proliferative potential and the ability to regenerate tumours consisting of phenotypically heterogeneous cell types. The identities of cancer stem cells (CSCs) that give rise to breast tumours are incompletely understood.

The mammary gland is composed of a complex cellular hierarchy, which undergoes most of its development postnatally. To achieve this great plasticity, both stem and progenitor cells play a pivotal role in the extensive tissue remodelling occurring during puberty and pregnancy. Deregulation of stem and progenitor cells is a key event in mammary carcinogenesis. Recently, the host laboratory identified a rare unipotent progenitor cell population in the adult murine mammary gland characterized by the surface protein leucine-rich repeat-containing G-protein coupled receptor 6 (Lgr6). Oncogenic mutations in Lgr6-positive cells led to the formation of luminal mammary gland tumours, and contributed to tumour aggressiveness and maintenance. Conversely, depletion of Lgr6-positive progenitors in mouse luminal breast cancer dramatically impaired tumour growth and morphology. However, the underlying molecular mechanisms driving these observations are unknown.

The aim of this project is the characterisation of Lgr6-positive breast cancer stem cells, using functional and molecular approaches. We will characterise the molecular differences between cancer stem cells and non-stem cells, with the ultimate goal of identifying novel therapeutic strategies to eliminate breast cancer stem cells.

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The information about "BRECASTEM" are provided by the European Opendata Portal: CORDIS opendata.

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