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BRECASTEM SIGNED

Functional and Molecular Characterisation of Breast Cancer Stem Cells

Total Cost €

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EC-Contrib. €

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Partnership

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 BRECASTEM project word cloud

Explore the words cloud of the BRECASTEM project. It provides you a very rough idea of what is the project "BRECASTEM" about.

deregulation    lineage    give    functional    play    protein    rare    tumour    unknown    heterogeneous    cancers    undergoes    morphology    cell    transforming    breast    capacities    depletion    impaired    cellular    homeostasis    progenitor    tumours    ultimate    therapeutic    pivotal    differentiation    event    hierarchy    progenitors    conversely    regeneration    incompletely    every    carcinogenesis    mouse    types    postnatally    consisting    maintenance    murine    lgr6    luminal    self    renewal    pregnancy    coupled    laboratory    puberty    stem    proliferative    cells    surface    underlying    containing    cscs    occurring    driving    eliminate    cancer    organ    replication    characterisation    positive    phenotypically    observations    mutations    differences    function    mammary    leucine    repeat    extensive    host    plasticity    harbours    population    strategies    adult    identities    receptor    dramatically    characterise    injury    gland    tissue    caused    harbour    molecular    remodelling    oncogenic    contributed    mechanisms    transformed    regenerate    aggressiveness    led    unipotent   

Project "BRECASTEM" data sheet

The following table provides information about the project.

Coordinator
THE FRANCIS CRICK INSTITUTE LIMITED 

Organization address
address: 1 MIDLAND ROAD
city: LONDON
postcode: NW1 1AT
website: www.crick.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
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 Coordinator Country United Kingdom [UK]
 Project website https://www.crick.ac.uk/research/labs/axel-behrens/areas-of-interest/lgr6-marks-a-cancerstem- cell-population-of-luminal-breast-cancer
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-03-01   to  2019-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE FRANCIS CRICK INSTITUTE LIMITED UK (LONDON) coordinator 183˙454.00

Map

 Project objective

Every organ harbours adult stem cells which have the potential for long-term replication, together with the capacities of self-renewal and multi-lineage differentiation. These stem cells function in tissue homeostasis and contribute to regeneration in response to injury. In addition, many cancers are caused by transforming mutations occurring in tissue-specific progenitor cells. These transformed stem cells harbour long-term proliferative potential and the ability to regenerate tumours consisting of phenotypically heterogeneous cell types. The identities of cancer stem cells (CSCs) that give rise to breast tumours are incompletely understood.

The mammary gland is composed of a complex cellular hierarchy, which undergoes most of its development postnatally. To achieve this great plasticity, both stem and progenitor cells play a pivotal role in the extensive tissue remodelling occurring during puberty and pregnancy. Deregulation of stem and progenitor cells is a key event in mammary carcinogenesis. Recently, the host laboratory identified a rare unipotent progenitor cell population in the adult murine mammary gland characterized by the surface protein leucine-rich repeat-containing G-protein coupled receptor 6 (Lgr6). Oncogenic mutations in Lgr6-positive cells led to the formation of luminal mammary gland tumours, and contributed to tumour aggressiveness and maintenance. Conversely, depletion of Lgr6-positive progenitors in mouse luminal breast cancer dramatically impaired tumour growth and morphology. However, the underlying molecular mechanisms driving these observations are unknown.

The aim of this project is the characterisation of Lgr6-positive breast cancer stem cells, using functional and molecular approaches. We will characterise the molecular differences between cancer stem cells and non-stem cells, with the ultimate goal of identifying novel therapeutic strategies to eliminate breast cancer stem cells.

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