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BRECASTEM SIGNED

Functional and Molecular Characterisation of Breast Cancer Stem Cells

Total Cost €

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EC-Contrib. €

0

Partnership

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 BRECASTEM project word cloud

Explore the words cloud of the BRECASTEM project. It provides you a very rough idea of what is the project "BRECASTEM" about.

identities    therapeutic    transformed    murine    tumours    postnatally    observations    every    tissue    protein    deregulation    cancer    positive    event    incompletely    breast    gland    lineage    maintenance    phenotypically    underlying    characterise    give    injury    dramatically    population    function    containing    caused    mammary    transforming    tumour    repeat    progenitor    play    mutations    unknown    morphology    cells    undergoes    organ    ultimate    extensive    eliminate    renewal    led    oncogenic    host    functional    strategies    cancers    rare    stem    receptor    molecular    pregnancy    carcinogenesis    mouse    cell    impaired    mechanisms    depletion    plasticity    characterisation    contributed    replication    harbour    coupled    conversely    unipotent    types    cellular    homeostasis    pivotal    differentiation    consisting    surface    aggressiveness    luminal    differences    lgr6    leucine    regeneration    progenitors    hierarchy    adult    laboratory    harbours    cscs    proliferative    occurring    heterogeneous    regenerate    driving    remodelling    capacities    self    puberty   

Project "BRECASTEM" data sheet

The following table provides information about the project.

Coordinator
THE FRANCIS CRICK INSTITUTE LIMITED 

Organization address
address: 1 MIDLAND ROAD
city: LONDON
postcode: NW1 1AT
website: www.crick.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
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 Coordinator Country United Kingdom [UK]
 Project website https://www.crick.ac.uk/research/labs/axel-behrens/areas-of-interest/lgr6-marks-a-cancerstem- cell-population-of-luminal-breast-cancer
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-03-01   to  2019-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE FRANCIS CRICK INSTITUTE LIMITED UK (LONDON) coordinator 183˙454.00

Map

 Project objective

Every organ harbours adult stem cells which have the potential for long-term replication, together with the capacities of self-renewal and multi-lineage differentiation. These stem cells function in tissue homeostasis and contribute to regeneration in response to injury. In addition, many cancers are caused by transforming mutations occurring in tissue-specific progenitor cells. These transformed stem cells harbour long-term proliferative potential and the ability to regenerate tumours consisting of phenotypically heterogeneous cell types. The identities of cancer stem cells (CSCs) that give rise to breast tumours are incompletely understood.

The mammary gland is composed of a complex cellular hierarchy, which undergoes most of its development postnatally. To achieve this great plasticity, both stem and progenitor cells play a pivotal role in the extensive tissue remodelling occurring during puberty and pregnancy. Deregulation of stem and progenitor cells is a key event in mammary carcinogenesis. Recently, the host laboratory identified a rare unipotent progenitor cell population in the adult murine mammary gland characterized by the surface protein leucine-rich repeat-containing G-protein coupled receptor 6 (Lgr6). Oncogenic mutations in Lgr6-positive cells led to the formation of luminal mammary gland tumours, and contributed to tumour aggressiveness and maintenance. Conversely, depletion of Lgr6-positive progenitors in mouse luminal breast cancer dramatically impaired tumour growth and morphology. However, the underlying molecular mechanisms driving these observations are unknown.

The aim of this project is the characterisation of Lgr6-positive breast cancer stem cells, using functional and molecular approaches. We will characterise the molecular differences between cancer stem cells and non-stem cells, with the ultimate goal of identifying novel therapeutic strategies to eliminate breast cancer stem cells.

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The information about "BRECASTEM" are provided by the European Opendata Portal: CORDIS opendata.

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