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BRECASTEM SIGNED

Functional and Molecular Characterisation of Breast Cancer Stem Cells

Total Cost €

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EC-Contrib. €

0

Partnership

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 BRECASTEM project word cloud

Explore the words cloud of the BRECASTEM project. It provides you a very rough idea of what is the project "BRECASTEM" about.

protein    characterisation    unknown    therapeutic    regenerate    lgr6    extensive    characterise    murine    lineage    mouse    caused    positive    remodelling    functional    homeostasis    types    molecular    impaired    deregulation    laboratory    stem    receptor    self    progenitors    luminal    maintenance    led    coupled    plasticity    phenotypically    mechanisms    surface    aggressiveness    undergoes    conversely    depletion    regeneration    leucine    strategies    incompletely    give    gland    population    function    ultimate    puberty    capacities    tumour    identities    oncogenic    containing    dramatically    host    renewal    breast    occurring    progenitor    eliminate    transforming    underlying    every    replication    differences    pivotal    tissue    event    cells    repeat    driving    pregnancy    harbour    transformed    cancer    mammary    differentiation    carcinogenesis    cancers    organ    morphology    observations    mutations    consisting    tumours    cell    postnatally    cellular    rare    heterogeneous    contributed    play    unipotent    harbours    injury    hierarchy    proliferative    cscs    adult   

Project "BRECASTEM" data sheet

The following table provides information about the project.

Coordinator
THE FRANCIS CRICK INSTITUTE LIMITED 

Organization address
address: 1 MIDLAND ROAD
city: LONDON
postcode: NW1 1AT
website: www.crick.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website https://www.crick.ac.uk/research/labs/axel-behrens/areas-of-interest/lgr6-marks-a-cancerstem- cell-population-of-luminal-breast-cancer
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-03-01   to  2019-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE FRANCIS CRICK INSTITUTE LIMITED UK (LONDON) coordinator 183˙454.00

Map

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 Project objective

Every organ harbours adult stem cells which have the potential for long-term replication, together with the capacities of self-renewal and multi-lineage differentiation. These stem cells function in tissue homeostasis and contribute to regeneration in response to injury. In addition, many cancers are caused by transforming mutations occurring in tissue-specific progenitor cells. These transformed stem cells harbour long-term proliferative potential and the ability to regenerate tumours consisting of phenotypically heterogeneous cell types. The identities of cancer stem cells (CSCs) that give rise to breast tumours are incompletely understood.

The mammary gland is composed of a complex cellular hierarchy, which undergoes most of its development postnatally. To achieve this great plasticity, both stem and progenitor cells play a pivotal role in the extensive tissue remodelling occurring during puberty and pregnancy. Deregulation of stem and progenitor cells is a key event in mammary carcinogenesis. Recently, the host laboratory identified a rare unipotent progenitor cell population in the adult murine mammary gland characterized by the surface protein leucine-rich repeat-containing G-protein coupled receptor 6 (Lgr6). Oncogenic mutations in Lgr6-positive cells led to the formation of luminal mammary gland tumours, and contributed to tumour aggressiveness and maintenance. Conversely, depletion of Lgr6-positive progenitors in mouse luminal breast cancer dramatically impaired tumour growth and morphology. However, the underlying molecular mechanisms driving these observations are unknown.

The aim of this project is the characterisation of Lgr6-positive breast cancer stem cells, using functional and molecular approaches. We will characterise the molecular differences between cancer stem cells and non-stem cells, with the ultimate goal of identifying novel therapeutic strategies to eliminate breast cancer stem cells.

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The information about "BRECASTEM" are provided by the European Opendata Portal: CORDIS opendata.

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