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BRECASTEM SIGNED

Functional and Molecular Characterisation of Breast Cancer Stem Cells

Total Cost €

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EC-Contrib. €

0

Partnership

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 BRECASTEM project word cloud

Explore the words cloud of the BRECASTEM project. It provides you a very rough idea of what is the project "BRECASTEM" about.

proliferative    morphology    maintenance    receptor    heterogeneous    organ    differentiation    luminal    population    breast    types    tumour    mutations    carcinogenesis    characterisation    murine    cells    cancer    occurring    ultimate    pregnancy    rare    differences    aggressiveness    postnatally    host    cscs    transformed    homeostasis    harbour    depletion    mammary    event    impaired    gland    eliminate    laboratory    capacities    adult    phenotypically    puberty    injury    molecular    renewal    cellular    play    remodelling    conversely    consisting    unipotent    harbours    replication    dramatically    function    extensive    functional    identities    incompletely    leucine    progenitors    characterise    protein    observations    pivotal    driving    mouse    tissue    oncogenic    led    underlying    lgr6    regeneration    therapeutic    plasticity    containing    cancers    every    hierarchy    cell    coupled    strategies    transforming    caused    stem    positive    contributed    repeat    regenerate    undergoes    surface    mechanisms    self    tumours    deregulation    progenitor    give    lineage    unknown   

Project "BRECASTEM" data sheet

The following table provides information about the project.

Coordinator
THE FRANCIS CRICK INSTITUTE LIMITED 

Organization address
address: 1 MIDLAND ROAD
city: LONDON
postcode: NW1 1AT
website: www.crick.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
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 Coordinator Country United Kingdom [UK]
 Project website https://www.crick.ac.uk/research/labs/axel-behrens/areas-of-interest/lgr6-marks-a-cancerstem- cell-population-of-luminal-breast-cancer
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-03-01   to  2019-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE FRANCIS CRICK INSTITUTE LIMITED UK (LONDON) coordinator 183˙454.00

Map

 Project objective

Every organ harbours adult stem cells which have the potential for long-term replication, together with the capacities of self-renewal and multi-lineage differentiation. These stem cells function in tissue homeostasis and contribute to regeneration in response to injury. In addition, many cancers are caused by transforming mutations occurring in tissue-specific progenitor cells. These transformed stem cells harbour long-term proliferative potential and the ability to regenerate tumours consisting of phenotypically heterogeneous cell types. The identities of cancer stem cells (CSCs) that give rise to breast tumours are incompletely understood.

The mammary gland is composed of a complex cellular hierarchy, which undergoes most of its development postnatally. To achieve this great plasticity, both stem and progenitor cells play a pivotal role in the extensive tissue remodelling occurring during puberty and pregnancy. Deregulation of stem and progenitor cells is a key event in mammary carcinogenesis. Recently, the host laboratory identified a rare unipotent progenitor cell population in the adult murine mammary gland characterized by the surface protein leucine-rich repeat-containing G-protein coupled receptor 6 (Lgr6). Oncogenic mutations in Lgr6-positive cells led to the formation of luminal mammary gland tumours, and contributed to tumour aggressiveness and maintenance. Conversely, depletion of Lgr6-positive progenitors in mouse luminal breast cancer dramatically impaired tumour growth and morphology. However, the underlying molecular mechanisms driving these observations are unknown.

The aim of this project is the characterisation of Lgr6-positive breast cancer stem cells, using functional and molecular approaches. We will characterise the molecular differences between cancer stem cells and non-stem cells, with the ultimate goal of identifying novel therapeutic strategies to eliminate breast cancer stem cells.

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