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BRECASTEM SIGNED

Functional and Molecular Characterisation of Breast Cancer Stem Cells

Total Cost €

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EC-Contrib. €

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Partnership

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 BRECASTEM project word cloud

Explore the words cloud of the BRECASTEM project. It provides you a very rough idea of what is the project "BRECASTEM" about.

laboratory    puberty    dramatically    transformed    gland    molecular    consisting    driving    positive    protein    surface    led    depletion    cell    harbour    receptor    therapeutic    organ    cancers    repeat    cscs    every    differentiation    cellular    carcinogenesis    coupled    harbours    stem    rare    hierarchy    incompletely    functional    eliminate    oncogenic    self    homeostasis    cancer    lgr6    mechanisms    leucine    progenitor    extensive    differences    breast    regeneration    pregnancy    cells    population    regenerate    heterogeneous    mouse    proliferative    renewal    caused    give    replication    luminal    tumours    impaired    underlying    unipotent    postnatally    injury    types    tissue    morphology    conversely    event    plasticity    unknown    mutations    pivotal    remodelling    characterisation    capacities    maintenance    contributed    transforming    mammary    adult    characterise    play    strategies    tumour    murine    identities    occurring    function    progenitors    phenotypically    aggressiveness    host    observations    lineage    deregulation    containing    undergoes    ultimate   

Project "BRECASTEM" data sheet

The following table provides information about the project.

Coordinator
THE FRANCIS CRICK INSTITUTE LIMITED 

Organization address
address: 1 MIDLAND ROAD
city: LONDON
postcode: NW1 1AT
website: www.crick.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
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 Coordinator Country United Kingdom [UK]
 Project website https://www.crick.ac.uk/research/labs/axel-behrens/areas-of-interest/lgr6-marks-a-cancerstem- cell-population-of-luminal-breast-cancer
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-03-01   to  2019-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE FRANCIS CRICK INSTITUTE LIMITED UK (LONDON) coordinator 183˙454.00

Map

 Project objective

Every organ harbours adult stem cells which have the potential for long-term replication, together with the capacities of self-renewal and multi-lineage differentiation. These stem cells function in tissue homeostasis and contribute to regeneration in response to injury. In addition, many cancers are caused by transforming mutations occurring in tissue-specific progenitor cells. These transformed stem cells harbour long-term proliferative potential and the ability to regenerate tumours consisting of phenotypically heterogeneous cell types. The identities of cancer stem cells (CSCs) that give rise to breast tumours are incompletely understood.

The mammary gland is composed of a complex cellular hierarchy, which undergoes most of its development postnatally. To achieve this great plasticity, both stem and progenitor cells play a pivotal role in the extensive tissue remodelling occurring during puberty and pregnancy. Deregulation of stem and progenitor cells is a key event in mammary carcinogenesis. Recently, the host laboratory identified a rare unipotent progenitor cell population in the adult murine mammary gland characterized by the surface protein leucine-rich repeat-containing G-protein coupled receptor 6 (Lgr6). Oncogenic mutations in Lgr6-positive cells led to the formation of luminal mammary gland tumours, and contributed to tumour aggressiveness and maintenance. Conversely, depletion of Lgr6-positive progenitors in mouse luminal breast cancer dramatically impaired tumour growth and morphology. However, the underlying molecular mechanisms driving these observations are unknown.

The aim of this project is the characterisation of Lgr6-positive breast cancer stem cells, using functional and molecular approaches. We will characterise the molecular differences between cancer stem cells and non-stem cells, with the ultimate goal of identifying novel therapeutic strategies to eliminate breast cancer stem cells.

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