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REJUVENATION SIGNED

Repair of Junctional Atrioventricular Conduction and Impulse Formation

Total Cost €

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EC-Contrib. €

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Project "REJUVENATION" data sheet

The following table provides information about the project.

Coordinator
ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM 

Organization address
address: MEIBERGDREEF 15
city: AMSTERDAM
postcode: 1105AZ
website: www.amc.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 1˙499˙995 €
 EC max contribution 1˙499˙995 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-04-01   to  2022-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM NL (AMSTERDAM) coordinator 1˙499˙995.00

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 Project objective

Background: To bypass hardware-related complication there have been substantial efforts to create biological pacemakers. Effective strategies have been identified and are now being refined for delivery of long-term function and clinical application. Yet, currently developed biological pacemakers only provide pacing to atrium or ventricle thereby aiming at ~20% of pacemaker patients. To unleash the full potential of biological pacing, targeting virtually every pacemaker patient, effective repair of atrio-ventricular (AV) conduction is crucial. With the arrival of advanced stem cell-based therapies, now is the time to meet this important challenge.

Objective: To develop a stem cell-based therapy that restores impulse formation and conduction at the interface between atrium and ventricle.

Approach: Human induced pluripotent stem cells (hiPSCs) will be used to produce cells with hallmark features of AV nodal cells. After in vitro testing, these cells will be implanted in vivo (together with biomaterials) to form AV bypass tracts in sheep that are in permanent AV block. In this setting, approaches will be tested for their ability to bridge electrical activity from the atrium to ventricle and protect the ventricle from atrial tachycardia. The final steps of this project focuses on the development of dedicated implantation catheters (in collaboration with Medtronic) and optimization of cellular constructs that are regulatory compliant and ready for clinical testing.

Impact: By developing novel therapies to re-establish AV impulse formation and conduction I will broaden the application area of biological pacing to nearly all patients. In Europe ~300.000 pacemakers are implanted annually representing cots of ~8 billion Euros. Five per cent of these implantations result in serious complications requiring re-implantation or other invasive treatments. Biological pacemakers are expected to reduce these complications, improve quality of life, and reduce healthcare costs.

 Publications

year authors and title journal last update
List of publications.
2019 Végh AMD, den Haan AD, Cócera Ortega L, Verkerk AO, Sluijter JPG, Bakker D, van Amersfoorth S, van Veen TAB, Klerk M, Seppen J, de Bakker JMT, Christoffels VM, Geerts D, Goumans MJTH, Tan HL, Boink GJJ
Cardiomyocyte Progenitor Cells as a Functional Gene Delivery Vehicle for Long-Term Biological Pacing
published pages: , ISSN: 1420-3049, DOI: 10.3390/molecules24010181
Molecules 2019-10-17
2018 Mohan RA, Mommersteeg MTM, Domínguez JN, Choquet C, Wakker V, de Gier-de Vries C, Boink GJJ, Boukens BJ, Miquerol L, Verkerk AO, Christoffels VM
Embryonic Tbx3+ cardiomyocytes form the mature cardiac conduction system by progressive fate restriction
published pages: , ISSN: 0950-1991, DOI: 10.1242/dev.167361
Development 2019-10-17
2018 Saritha Adepu, Erik Oosterwerff, Vincent Christoffels, Gerard Boink
Direct Reprograming to Regenerate Myocardium and Repair Its Pacemaker and Conduction System
published pages: 48, ISSN: 2305-6320, DOI: 10.3390/medicines5020048
Medicines 5/2 2019-09-02
2018 Vincent W. W. van Eif, Harsha D. Devalla, Gerard J. J. Boink, Vincent M. Christoffels
Transcriptional regulation of the cardiac conduction system
published pages: , ISSN: 1759-5002, DOI: 10.1038/s41569-018-0031-y
Nature Reviews Cardiology 2019-09-02

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The information about "REJUVENATION" are provided by the European Opendata Portal: CORDIS opendata.

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