Explore the words cloud of the REJUVENATION project. It provides you a very rough idea of what is the project "REJUVENATION" about.
The following table provides information about the project.
ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM
|Coordinator Country||Netherlands [NL]|
|Total cost||1˙499˙995 €|
|EC max contribution||1˙499˙995 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2017-04-01 to 2022-03-31|
Take a look of project's partnership.
|1||ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM||NL (AMSTERDAM)||coordinator||1˙499˙995.00|
Background: To bypass hardware-related complication there have been substantial efforts to create biological pacemakers. Effective strategies have been identified and are now being refined for delivery of long-term function and clinical application. Yet, currently developed biological pacemakers only provide pacing to atrium or ventricle thereby aiming at ~20% of pacemaker patients. To unleash the full potential of biological pacing, targeting virtually every pacemaker patient, effective repair of atrio-ventricular (AV) conduction is crucial. With the arrival of advanced stem cell-based therapies, now is the time to meet this important challenge.
Objective: To develop a stem cell-based therapy that restores impulse formation and conduction at the interface between atrium and ventricle.
Approach: Human induced pluripotent stem cells (hiPSCs) will be used to produce cells with hallmark features of AV nodal cells. After in vitro testing, these cells will be implanted in vivo (together with biomaterials) to form AV bypass tracts in sheep that are in permanent AV block. In this setting, approaches will be tested for their ability to bridge electrical activity from the atrium to ventricle and protect the ventricle from atrial tachycardia. The final steps of this project focuses on the development of dedicated implantation catheters (in collaboration with Medtronic) and optimization of cellular constructs that are regulatory compliant and ready for clinical testing.
Impact: By developing novel therapies to re-establish AV impulse formation and conduction I will broaden the application area of biological pacing to nearly all patients. In Europe ~300.000 pacemakers are implanted annually representing cots of ~8 billion Euros. Five per cent of these implantations result in serious complications requiring re-implantation or other invasive treatments. Biological pacemakers are expected to reduce these complications, improve quality of life, and reduce healthcare costs.
|year||authors and title||journal||last update|
VÃ©gh AMD, den Haan AD, CÃ³cera Ortega L, Verkerk AO, Sluijter JPG, Bakker D, van Amersfoorth S, van Veen TAB, Klerk M, Seppen J, de Bakker JMT, Christoffels VM, Geerts D, Goumans MJTH, Tan HL, Boink GJJ
Cardiomyocyte Progenitor Cells as a Functional Gene Delivery Vehicle for Long-Term Biological Pacing
published pages: , ISSN: 1420-3049, DOI: 10.3390/molecules24010181
Mohan RA, Mommersteeg MTM, DomÃnguez JN, Choquet C, Wakker V, de Gier-de Vries C, Boink GJJ, Boukens BJ, Miquerol L, Verkerk AO, Christoffels VM
Embryonic Tbx3+ cardiomyocytes form the mature cardiac conduction system by progressive fate restriction
published pages: , ISSN: 0950-1991, DOI: 10.1242/dev.167361
Saritha Adepu, Erik Oosterwerff, Vincent Christoffels, Gerard Boink
Direct Reprograming to Regenerate Myocardium and Repair Its Pacemaker and Conduction System
published pages: 48, ISSN: 2305-6320, DOI: 10.3390/medicines5020048
Vincent W. W. van Eif, Harsha D. Devalla, Gerard J. J. Boink, Vincent M. Christoffels
Transcriptional regulation of theÂ cardiac conduction system
published pages: , ISSN: 1759-5002, DOI: 10.1038/s41569-018-0031-y
|Nature Reviews Cardiology||2019-09-02|
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "REJUVENATION" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (firstname.lastname@example.org) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "REJUVENATION" are provided by the European Opendata Portal: CORDIS opendata.
Righting Victim Participation in Transitional JusticeRead More
Elucidating the development of sexually-dimorphic circuits: from molecular mechanisms to synapses and behaviorRead More
BIOHYBRID AND BIODEGRADABLE NANOVACCINES FOR CANCER IMMUNOTHERAPYRead More