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NeuroModSense

Peptidergic Neuromodulation of Sensory Representation in the Brain

Total Cost €

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EC-Contrib. €

0

Partnership

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 NeuroModSense project word cloud

Explore the words cloud of the NeuroModSense project. It provides you a very rough idea of what is the project "NeuroModSense" about.

interact    expertise    bulb    neurotoxin    question    environment    smell    influence    visualise    visual    transparent    genetically    discrete    function    touch    decoupled    ablation    gonadotropin    genes    sleep    altering    fundamental    amenable    vertebrate    neuroscience    hormone    vertebrates    natural    synaptic    manipulating    vivo    inputs    reveal    starved    disorders    dispersed    expressing    olfactory    depends    conserved    input    neurons    manipulate    chemosensory    stress    odour    obesity    responds    neuropeptides    animals    receptor    suggest    hence    neuronal    wakefulness    gnrh    genetic    ex    feeding    ultimately    genetics    host    unites    auditory    modulate    molecular    taste    ob    neuromodulators    cues    zebrafish    model    antagonistically    play    effect    npy    anorexia    neuropeptide    brain    populations    optically    reproductive    behaviours    animal    label    fed    optogenetics    basal    odours    cell    releasing    frontier    first    mediating    internal    sensory   

Project "NeuroModSense" data sheet

The following table provides information about the project.

Coordinator
NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU 

Organization address
address: HOGSKOLERINGEN 1
city: TRONDHEIM
postcode: 7491
website: www.ntnu.no

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Norway [NO]
 Total cost 208˙400 €
 EC max contribution 208˙400 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-03-01   to  2019-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU NO (TRONDHEIM) coordinator 208˙400.00

Map

 Project objective

Animals interact with and respond to their environment by processing sensory inputs such as visual and auditory cues, touch, taste and smell. How an animal responds to sensory inputs however depends on its internal state (e.g. sleep, wakefulness, stress, fed or starved conditions), such that the same sensory input can produce different behaviours. Neuromodulators play an important role in mediating the internal state of the animal. Neuropeptide Y (NPY) and Gonadotropin-releasing hormone (GnRH) are neuropeptides that are conserved across vertebrates and modulate feeding and reproductive behaviours, antagonistically. They are produced by discrete neuronal populations, and are dispersed widely throughout the brain. Studies suggest that both GnRH/NPY modulate the basal olfactory response by altering the synaptic properties of olfactory receptor neurons. However, it is not known how GnRH/NPY influence the processing of chemosensory information in the olfactory bulb (OB) and ultimately odour driven behaviour. Here, I will use an optically transparent and genetically amenable vertebrate model, zebrafish to study brain function and behaviour. First, I will use genetic methods to specifically label, and visualise the activity of the GnRH/NPY neurons in response to natural odours ex vivo. Next, I will manipulate the activity of these neurons using optogenetics and by expressing neurotoxin/cell ablation genes, and study the effect on olfactory processing in the OB. Finally, after manipulating the activity of GnRH/NPY neurons, I will analyse the effect on odour driven behaviour. This will reveal the role of these neuromodulators in olfactory processing and hence on odour driven behaviour in vertebrates. This project unites my expertise in molecular genetics with that of my host in frontier neuroscience to address a fundamental question of sensory processing, relevant for understanding disorders in which behaviour is decoupled from internal state (e.g. obesity/anorexia).

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The information about "NEUROMODSENSE" are provided by the European Opendata Portal: CORDIS opendata.

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