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NeuroModSense

Peptidergic Neuromodulation of Sensory Representation in the Brain

Total Cost €

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EC-Contrib. €

0

Partnership

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 NeuroModSense project word cloud

Explore the words cloud of the NeuroModSense project. It provides you a very rough idea of what is the project "NeuroModSense" about.

environment    decoupled    fed    internal    depends    optogenetics    gnrh    genetics    visual    sleep    discrete    synaptic    odour    obesity    inputs    vertebrate    populations    ex    transparent    cues    dispersed    basal    bulb    influence    function    first    brain    amenable    conserved    olfactory    frontier    molecular    host    mediating    touch    neuropeptide    reproductive    behaviours    fundamental    starved    expressing    play    genetic    receptor    manipulate    unites    hormone    sensory    optically    feeding    interact    visualise    neurotoxin    hence    manipulating    vivo    releasing    neuronal    effect    smell    ablation    odours    animals    wakefulness    genes    altering    neuromodulators    anorexia    chemosensory    input    auditory    taste    responds    zebrafish    reveal    vertebrates    gonadotropin    stress    disorders    ultimately    neurons    npy    cell    model    ob    animal    antagonistically    neuroscience    suggest    modulate    expertise    question    neuropeptides    label    genetically    natural   

Project "NeuroModSense" data sheet

The following table provides information about the project.

Coordinator
NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU 

Organization address
address: HOGSKOLERINGEN 1
city: TRONDHEIM
postcode: 7491
website: www.ntnu.no

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Norway [NO]
 Total cost 208˙400 €
 EC max contribution 208˙400 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-03-01   to  2019-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU NO (TRONDHEIM) coordinator 208˙400.00

Map

 Project objective

Animals interact with and respond to their environment by processing sensory inputs such as visual and auditory cues, touch, taste and smell. How an animal responds to sensory inputs however depends on its internal state (e.g. sleep, wakefulness, stress, fed or starved conditions), such that the same sensory input can produce different behaviours. Neuromodulators play an important role in mediating the internal state of the animal. Neuropeptide Y (NPY) and Gonadotropin-releasing hormone (GnRH) are neuropeptides that are conserved across vertebrates and modulate feeding and reproductive behaviours, antagonistically. They are produced by discrete neuronal populations, and are dispersed widely throughout the brain. Studies suggest that both GnRH/NPY modulate the basal olfactory response by altering the synaptic properties of olfactory receptor neurons. However, it is not known how GnRH/NPY influence the processing of chemosensory information in the olfactory bulb (OB) and ultimately odour driven behaviour. Here, I will use an optically transparent and genetically amenable vertebrate model, zebrafish to study brain function and behaviour. First, I will use genetic methods to specifically label, and visualise the activity of the GnRH/NPY neurons in response to natural odours ex vivo. Next, I will manipulate the activity of these neurons using optogenetics and by expressing neurotoxin/cell ablation genes, and study the effect on olfactory processing in the OB. Finally, after manipulating the activity of GnRH/NPY neurons, I will analyse the effect on odour driven behaviour. This will reveal the role of these neuromodulators in olfactory processing and hence on odour driven behaviour in vertebrates. This project unites my expertise in molecular genetics with that of my host in frontier neuroscience to address a fundamental question of sensory processing, relevant for understanding disorders in which behaviour is decoupled from internal state (e.g. obesity/anorexia).

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The information about "NEUROMODSENSE" are provided by the European Opendata Portal: CORDIS opendata.

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