Explore the words cloud of the MaintainMeth project. It provides you a very rough idea of what is the project "MaintainMeth" about.
The following table provides information about the project.
JOHN INNES CENTRE
|Coordinator Country||United Kingdom [UK]|
|Total cost||2˙749˙962 €|
|EC max contribution||2˙749˙962 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2017-04-01 to 2022-03-31|
Take a look of project's partnership.
|1||JOHN INNES CENTRE||UK (NORWICH)||coordinator||2˙749˙962.00|
Cytosine methylation is a chemical modification that is precisely copied when DNA is replicated. Because methylation can regulate gene expression, accurate reproduction of DNA methylation patterns is essential for plant and animal development and for human health. The enzymes that maintain DNA methylation have to work within chromatin, and particularly to contend with nucleosomes – tight complexes of DNA and histone proteins. How methylation of nucleosomal DNA is maintained remains unknown, and even the simple matter of whether nucleosomes hinder or promote methylation is controversial.
My laboratory’s recent work with DDM1 – an ancient protein conserved between plants and animals that can move nucleosomes – and linker histone H1, which binds to nucleosomes and the intervening ‘linker’ DNA, has allowed us to formulate a model wherein movement of nucleosomes by DDM1 dislodges H1 and allows methyltransferases to access the DNA. Furthermore, this work revealed the existence of unknown factors required to maintain DNA methylation. My laboratory also discovered that DNA methylation influences nucleosome placement, thereby demonstrating that the interaction between DNA methylation and nucleosomes is bidirectional.
My goal is now to deeply understand the connected processes of maintenance methylation and nucleosome placement. This will be achieved through three interconnected research strands: 1) Elucidation of how DNA methylation is maintained within chromatin. 2) Identification of new DNA methylation maintenance factors. 3) Determination of how DNA methylation influences nucleosomes in vivo.
Our ultimate output will be the creation of a mathematical model of DNA methylation maintenance that will incorporate the bidirectional interactions between methylation and nucleosomes. This breakthrough will revolutionize research in the field by permitting the development of precise, quantitative hypotheses about the maintenance and function of DNA methylation within chromatin.
|year||authors and title||journal||last update|
Jaemyung Choi, David B. Lyons, M. Yvonne Kim, Jonathan D. Moore, Daniel Zilberman
DNA Methylation and Histone H1 Jointly Repress Transposable Elements and Aberrant Intragenic Transcripts
published pages: , ISSN: 1097-2765, DOI: 10.1016/j.molcel.2019.10.011
Keith D. Harris, James P. B. Lloyd, Katherine Domb, Daniel Zilberman, Assaf Zemach
DNA methylation is maintained with high fidelity in the honey bee germline and exhibits global non-functional fluctuations during somatic development
published pages: , ISSN: 1756-8935, DOI: 10.1186/s13072-019-0307-4
|Epigenetics & Chromatin 12/1||2019-12-16|
David B Lyons, Daniel Zilberman
DDM1 and Lsh remodelers allow methylation of DNA wrapped in nucleosomes
published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.30674
An evolutionary case for functional gene body methylation in plants and animals
published pages: , ISSN: 1474-760X, DOI: 10.1186/s13059-017-1230-2
|Genome Biology 18/1||2019-05-15|
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