Opendata, web and dolomites

REVERSING TAUOPATHY

Identifying and deciphering the mechanism of the cellular machinery responsible for disaggregation of intracellular prion-like Tau aggregates

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 REVERSING TAUOPATHY project word cloud

Explore the words cloud of the REVERSING TAUOPATHY project. It provides you a very rough idea of what is the project "REVERSING TAUOPATHY" about.

mechanism    involvement    confocal    individually    scientist    aggregate    benefit    neurodegenerative    tagged    resolution    hartl    quantification    fluorescence    researcher    hek293    sirna    stable    world    humankind    responsible    regard    mass    amino    components    realizing    disaggregation    cure    prof    intellectually    disease    environment    culture    filter    diseases    cell    brain    cells    protein    labeling    mpib    efforts    trap    downregulated    lab    tomography    stimulating    group    prion    combination    lines    electron    labeled    disassembly    besides    aggregates    vitro    candidate    visualizing    tau    quantitative    alzheimer    true    isotope    machinery    deciphering    intracellular    aggregation    wolfgang    acids    giving    facilities    proteins    baumeister    yellow    cellular    microscopy    starvation    assay    therapeutics    play    silac    urgently    cryo    spectrometry    pathogenesis    tauopathies    grow    yfp    despite    me   

Project "REVERSING TAUOPATHY" data sheet

The following table provides information about the project.

Coordinator
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: MUENCHEN
postcode: 80539
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website https://www.biochem.mpg.de/en
 Total cost 171˙460 €
 EC max contribution 171˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-06-01   to  2019-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) coordinator 171˙460.00

Map

 Project objective

Tauopathies are a group of neurodegenerative diseases, the most common of them being Alzheimer’s disease, which are associated with the aggregation of protein Tau in the brain. Despite major research efforts world-wide, the mechanism of Tau aggregation and its pathogenesis giving rise to such neurodegenerative diseases is not yet understood. Therapeutics to cure these tauopathies, including Alzheimer’s disease, are urgently needed. We aim to identify the conditions, the cellular machinery responsible and the mechanism of disaggregation of intracellular prion-like Tau aggregates in HEK293 cell lines, with one condition already been identified (starvation). For identifying the conditions of disaggregation, high resolution confocal microscopy will be used for visualizing intracellular Tau aggregates tagged with yellow fluorescence protein (YFP). For deciphering the cellular components responsible for disaggregation, the proteins associated with the aggregates will be identified using quantitative mass spectrometry from SILAC (stable isotope labeling with amino acids in cell culture) labeled cells. Moreover, candidate factors will be downregulated by siRNA to establish their involvement in aggregate disassembly. Such components individually and in combination will then be analyzed for their disaggregation activity in vitro using filter trap assay for the quantification of disaggregation. Cryo-electron tomography of Tau aggregates under various conditions (e.g. during disaggregation) will be carried out in collaboration with Prof. Wolfgang Baumeister (MPIB). Besides contributing to the benefit of humankind, the proposed research work on neurodegenerative diseases will allow me to grow as a researcher and will help me in realizing my true potential as a scientist. The MPIB and the Hartl lab in particular will play an important role in this regard due the availability of state-of-the-art research facilities and an intellectually stimulating environment.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "REVERSING TAUOPATHY" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "REVERSING TAUOPATHY" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

ICARUS (2020)

Information Content of locAlisation: fRom classical to qUantum Systems

Read More  

TRACE-AD (2019)

Tracking the Effects of Amyloid and Tau Pathology on Brain Systems and Cognition in Early Alzheimer’s Disease

Read More  

GW (2019)

Analysing the heavy element factories of the Universe : photometric and spectroscopic sample study of kilonovae

Read More