Opendata, web and dolomites

REVERSING TAUOPATHY

Identifying and deciphering the mechanism of the cellular machinery responsible for disaggregation of intracellular prion-like Tau aggregates

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 REVERSING TAUOPATHY project word cloud

Explore the words cloud of the REVERSING TAUOPATHY project. It provides you a very rough idea of what is the project "REVERSING TAUOPATHY" about.

trap    quantification    culture    labeled    environment    stable    labeling    candidate    therapeutics    tomography    spectrometry    downregulated    hek293    disease    urgently    disaggregation    starvation    cell    intracellular    mechanism    intellectually    scientist    me    play    tagged    combination    efforts    filter    aggregates    benefit    regard    giving    cryo    mpib    amino    cure    proteins    researcher    baumeister    alzheimer    realizing    aggregate    cells    quantitative    aggregation    silac    microscopy    acids    sirna    responsible    hartl    tauopathies    lines    yfp    fluorescence    machinery    yellow    neurodegenerative    humankind    visualizing    true    assay    facilities    disassembly    protein    wolfgang    prof    components    mass    lab    isotope    tau    prion    deciphering    pathogenesis    group    resolution    grow    confocal    world    involvement    stimulating    besides    diseases    despite    individually    electron    vitro    brain    cellular   

Project "REVERSING TAUOPATHY" data sheet

The following table provides information about the project.

Coordinator
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: MUENCHEN
postcode: 80539
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website https://www.biochem.mpg.de/en
 Total cost 171˙460 €
 EC max contribution 171˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-06-01   to  2019-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) coordinator 171˙460.00

Map

 Project objective

Tauopathies are a group of neurodegenerative diseases, the most common of them being Alzheimer’s disease, which are associated with the aggregation of protein Tau in the brain. Despite major research efforts world-wide, the mechanism of Tau aggregation and its pathogenesis giving rise to such neurodegenerative diseases is not yet understood. Therapeutics to cure these tauopathies, including Alzheimer’s disease, are urgently needed. We aim to identify the conditions, the cellular machinery responsible and the mechanism of disaggregation of intracellular prion-like Tau aggregates in HEK293 cell lines, with one condition already been identified (starvation). For identifying the conditions of disaggregation, high resolution confocal microscopy will be used for visualizing intracellular Tau aggregates tagged with yellow fluorescence protein (YFP). For deciphering the cellular components responsible for disaggregation, the proteins associated with the aggregates will be identified using quantitative mass spectrometry from SILAC (stable isotope labeling with amino acids in cell culture) labeled cells. Moreover, candidate factors will be downregulated by siRNA to establish their involvement in aggregate disassembly. Such components individually and in combination will then be analyzed for their disaggregation activity in vitro using filter trap assay for the quantification of disaggregation. Cryo-electron tomography of Tau aggregates under various conditions (e.g. during disaggregation) will be carried out in collaboration with Prof. Wolfgang Baumeister (MPIB). Besides contributing to the benefit of humankind, the proposed research work on neurodegenerative diseases will allow me to grow as a researcher and will help me in realizing my true potential as a scientist. The MPIB and the Hartl lab in particular will play an important role in this regard due the availability of state-of-the-art research facilities and an intellectually stimulating environment.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "REVERSING TAUOPATHY" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "REVERSING TAUOPATHY" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

NaWaTL (2020)

Narrative, Writing, and the Teotihuacan Language: Exploring Language History Through Phylogenetics, Epigraphy and Iconography

Read More  

KOMODOH (2020)

From molecules to communities: unraveling ecological drivers of interactions between oaks and their insect herbivores

Read More  

STOPFIRE (2019)

Emergency Decision Support System of Offshore Platform Fires

Read More