Explore the words cloud of the SHAPPI project. It provides you a very rough idea of what is the project "SHAPPI" about.
The following table provides information about the project.
UNIVERSITY OF LEEDS
|Coordinator Country||United Kingdom [UK]|
|Total cost||183˙454 €|
|EC max contribution||183˙454 € (100%)|
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
|Duration (year-month-day)||from 2017-05-01 to 2019-04-30|
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Protein-protein interactions (PPIs) control all cellular processes relevant to health and disease, hence an outstanding challenge in chemical biology is to develop generic approaches for PPI inhibition. Such inhibitors (or chemical probes) represent unique tools to understand biological processes and starting points for drug discovery, for treatment of multiple illnesses for which effective treatments don’t currently exist e.g. cancer.
SHAPPI will allow Zsofia Hegedus (the fellow) to join the laboratory of Andrew Wilson (host supervisor) at the University of Leeds (Host) and develop research expertise in the area of inhibiting protein-protein interactions. In doing so, she will (a) enhance her prospects to become an independent academic group leader and (b) address the need to train researchers in this key area of chemical biology and (c) develop cutting edge methods that advance peptidomimetic approaches for inhibition of protein-protein interactions. Scaffold hybridization will allow the combination of molecular scaffolds capable of hot spot mimicry with molecules that influence selectivity or potency. In combination with reversible chemistry this will allow generation of dynamic combinatorial libraries of rapid identification of selective and potent inhibitors. The fellowship will explore proteomimetic-peptide conjugates and peptide-small molecule dynamic combinatorial libraries to accelerate development of selective PPI inhibitors using two model interactions; HIF-1α/p300 and BID/BAX, both of which represent important targets for anticancer therapy.
|year||authors and title||journal||last update|
Zsofia Hegedus, Claire M. Grison, Jennifer A. Miles, Silvia Rodriguez-Marin, Stuart L. Warriner, Michael E. Webb, Andrew J. Wilson
A catalytic proteinâ€“proteomimetic complex: using aromatic oligoamide foldamers as activators of RNase S
published pages: 3956-3962, ISSN: 2041-6520, DOI: 10.1039/c9sc00374f
|Chemical Science 10/14||2019-09-25|
May Bakail, Silvia Rodriguezâ€Marin, ZsÃ³fia HegedÃ¼s, Marie E. Perrin, FranÃ§oise Ochsenbein, Andrew J. Wilson
Recognition of ASF1 by Using Hydrocarbonâ€Constrained Peptides
published pages: 891-895, ISSN: 1439-4227, DOI: 10.1002/cbic.201800633
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