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GREEN-SPECIALISTS SIGNED

Specialised plant cell types via developmentally-controlled gene knockouts: a key step towards fully customised plants

Total Cost €

0

EC-Contrib. €

0

Partnership

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 GREEN-SPECIALISTS project word cloud

Explore the words cloud of the GREEN-SPECIALISTS project. It provides you a very rough idea of what is the project "GREEN-SPECIALISTS" about.

producer    cas9    types    biology    multiple    light    programs    ideal    deliberately    gene    action    programmed    cell    chemical    engineering    specialised    sophisticated    attracting    co2    deletions    property    knockout    crispr    community    point    platforms    opportunity    energy    external    activation    toward    made    biochemistry    metabolic    plant    proposes    class    knockouts    advantages    collaborations    autotrophy    genetic    strategies    homozygous    solar    cells    biosynthesis    chimeric    realising    systemic    broad    editing    multicellular    extensive    introduce    expertise    knock    plants    engineered    metabolites    efficiency    specialist    differentiation    natural    match    valuable    outs    instructions    host    intellectual    successful    published    synthetic    competing    independent    desirable    organisms    career    forming    parts    diversify    examples    yield    generate    world    ing    combine    skills    fail    validate    developmentally   

Project "GREEN-SPECIALISTS" data sheet

The following table provides information about the project.

Coordinator
KOBENHAVNS UNIVERSITET 

Organization address
address: NORREGADE 10
city: KOBENHAVN
postcode: 1165
website: www.ku.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 200˙194 €
 EC max contribution 200˙194 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-03-01   to  2020-02-29

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) coordinator 200˙194.00

Map

 Project objective

A goal of plant engineering is to produce valuable resources from CO2 and solar energy while exploiting the natural advantages of plants as production platforms. Plants have highly specialised cell types and sophisticated development programs, resulting in specialist producer cells that are supported by non-producer parts. Plants are the only organisms that combine autotrophy and extensive multicellular differentiation, yet current engineering strategies fail to fully exploit the potential advantages of plants as chemical production systems. This action proposes to develop and demonstrate a crucial technical advance in plant engineering: developmentally-programmed gene knock-outs in specialised cell types. Genetic knockout of competing metabolic pathways is essential to improving the yield of desirable metabolites. CRISPR/Cas9 gene editing in plants has been developed to the point where multiple homozygous gene knockouts can be made with high efficiency, but in all published examples the knockouts are systemic (i.e. present in every cell). I propose to introduce and validate a set of instructions that program the activation of CRISPR/Cas9 in specific cell types during plant development, resulting in gene deletions only in the targeted cells. The ability to produce chimeric plants with deliberately engineered specialist cell types is an essential step toward realising the potential of plant engineering. This action will generate intellectual property and a set of methods that will be useful to the wider plant research community. My broad experience in systems and synthetic biology and the world-class expertise of the host institution in plant biochemistry and light-driven biosynthesis are an ideal match for success in this action. Successful implementation will develop and diversify my skills while creating an ideal opportunity for independent career development, including attracting further funding and forming external collaborations.

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The information about "GREEN-SPECIALISTS" are provided by the European Opendata Portal: CORDIS opendata.

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