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GREEN-SPECIALISTS SIGNED

Specialised plant cell types via developmentally-controlled gene knockouts: a key step towards fully customised plants

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 GREEN-SPECIALISTS project word cloud

Explore the words cloud of the GREEN-SPECIALISTS project. It provides you a very rough idea of what is the project "GREEN-SPECIALISTS" about.

sophisticated    plants    activation    organisms    independent    light    forming    examples    competing    metabolites    multiple    genetic    platforms    specialised    cas9    knockout    diversify    types    extensive    proposes    programmed    fail    programs    career    introduce    point    generate    synthetic    differentiation    world    match    specialist    efficiency    knockouts    metabolic    co2    deliberately    advantages    chemical    opportunity    external    chimeric    cells    published    property    biochemistry    class    made    producer    validate    knock    engineering    energy    combine    community    attracting    ideal    solar    instructions    plant    expertise    yield    deletions    developmentally    strategies    skills    natural    autotrophy    parts    gene    desirable    successful    outs    action    broad    toward    host    engineered    systemic    multicellular    editing    realising    valuable    biosynthesis    homozygous    ing    collaborations    cell    biology    intellectual    crispr   

Project "GREEN-SPECIALISTS" data sheet

The following table provides information about the project.

Coordinator
KOBENHAVNS UNIVERSITET 

Organization address
address: NORREGADE 10
city: KOBENHAVN
postcode: 1165
website: www.ku.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 200˙194 €
 EC max contribution 200˙194 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-03-01   to  2020-02-29

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) coordinator 200˙194.00

Map

 Project objective

A goal of plant engineering is to produce valuable resources from CO2 and solar energy while exploiting the natural advantages of plants as production platforms. Plants have highly specialised cell types and sophisticated development programs, resulting in specialist producer cells that are supported by non-producer parts. Plants are the only organisms that combine autotrophy and extensive multicellular differentiation, yet current engineering strategies fail to fully exploit the potential advantages of plants as chemical production systems. This action proposes to develop and demonstrate a crucial technical advance in plant engineering: developmentally-programmed gene knock-outs in specialised cell types. Genetic knockout of competing metabolic pathways is essential to improving the yield of desirable metabolites. CRISPR/Cas9 gene editing in plants has been developed to the point where multiple homozygous gene knockouts can be made with high efficiency, but in all published examples the knockouts are systemic (i.e. present in every cell). I propose to introduce and validate a set of instructions that program the activation of CRISPR/Cas9 in specific cell types during plant development, resulting in gene deletions only in the targeted cells. The ability to produce chimeric plants with deliberately engineered specialist cell types is an essential step toward realising the potential of plant engineering. This action will generate intellectual property and a set of methods that will be useful to the wider plant research community. My broad experience in systems and synthetic biology and the world-class expertise of the host institution in plant biochemistry and light-driven biosynthesis are an ideal match for success in this action. Successful implementation will develop and diversify my skills while creating an ideal opportunity for independent career development, including attracting further funding and forming external collaborations.

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The information about "GREEN-SPECIALISTS" are provided by the European Opendata Portal: CORDIS opendata.

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