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Specialised plant cell types via developmentally-controlled gene knockouts: a key step towards fully customised plants

Total Cost €


EC-Contrib. €






 GREEN-SPECIALISTS project word cloud

Explore the words cloud of the GREEN-SPECIALISTS project. It provides you a very rough idea of what is the project "GREEN-SPECIALISTS" about.

producer    knock    generate    systemic    yield    crispr    extensive    natural    multicellular    homozygous    diversify    sophisticated    competing    synthetic    programmed    cells    specialised    multiple    light    skills    toward    biology    expertise    cas9    knockouts    combine    ideal    outs    successful    types    cell    world    class    valuable    co2    instructions    intellectual    specialist    career    differentiation    property    forming    autotrophy    engineering    organisms    efficiency    proposes    attracting    strategies    developmentally    community    plants    match    realising    deliberately    point    host    platforms    broad    advantages    made    published    examples    metabolites    genetic    independent    validate    external    chemical    introduce    gene    energy    fail    solar    plant    action    knockout    opportunity    biosynthesis    desirable    parts    metabolic    chimeric    collaborations    programs    biochemistry    activation    editing    engineered    ing    deletions   

Project "GREEN-SPECIALISTS" data sheet

The following table provides information about the project.


Organization address
address: NORREGADE 10
postcode: 1165

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 200˙194 €
 EC max contribution 200˙194 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-03-01   to  2020-02-29


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) coordinator 200˙194.00


 Project objective

A goal of plant engineering is to produce valuable resources from CO2 and solar energy while exploiting the natural advantages of plants as production platforms. Plants have highly specialised cell types and sophisticated development programs, resulting in specialist producer cells that are supported by non-producer parts. Plants are the only organisms that combine autotrophy and extensive multicellular differentiation, yet current engineering strategies fail to fully exploit the potential advantages of plants as chemical production systems. This action proposes to develop and demonstrate a crucial technical advance in plant engineering: developmentally-programmed gene knock-outs in specialised cell types. Genetic knockout of competing metabolic pathways is essential to improving the yield of desirable metabolites. CRISPR/Cas9 gene editing in plants has been developed to the point where multiple homozygous gene knockouts can be made with high efficiency, but in all published examples the knockouts are systemic (i.e. present in every cell). I propose to introduce and validate a set of instructions that program the activation of CRISPR/Cas9 in specific cell types during plant development, resulting in gene deletions only in the targeted cells. The ability to produce chimeric plants with deliberately engineered specialist cell types is an essential step toward realising the potential of plant engineering. This action will generate intellectual property and a set of methods that will be useful to the wider plant research community. My broad experience in systems and synthetic biology and the world-class expertise of the host institution in plant biochemistry and light-driven biosynthesis are an ideal match for success in this action. Successful implementation will develop and diversify my skills while creating an ideal opportunity for independent career development, including attracting further funding and forming external collaborations.

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The information about "GREEN-SPECIALISTS" are provided by the European Opendata Portal: CORDIS opendata.

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