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ExItALS

RNA-mediated intercellular miscommunication: role of extracellular vesicle cargos in Amyotrophic Lateral Sclerosis

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 ExItALS project word cloud

Explore the words cloud of the ExItALS project. It provides you a very rough idea of what is the project "ExItALS" about.

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Project "ExItALS" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITA DEGLI STUDI DI TRENTO 

Organization address
address: VIA CALEPINA 14
city: TRENTO
postcode: 38122
website: www.unitn.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Project website https://www.cibio.unitn.it/172/laboratory-of-transcriptional-neurobiology
 Total cost 180˙277 €
 EC max contribution 180˙277 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2017
 Duration (year-month-day) from 2017-04-01   to  2019-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI TRENTO IT (TRENTO) coordinator 180˙277.00

Map

 Project objective

Amyotrophic Lateral Sclerosis (ALS) is a rare neurodegenerative disorder that primarily targets upper and lower motor neurons. The progression of the disease is mediated by altered intercellular communication in the spinal cord between neurons and glial cells. Intercellular communication, mainly happening through extracellular vesicles (EVs) is responsible for the horizontal transfer of proteins and RNAs to recipient cells. Recently, I proved that EVs released from ALS mutant astrocytes selectively induced toxicity in wild type motor neuron, thus reinforcing the notion that astrocytes exert toxicity in ALS disease propagation and suggesting EVs as mediators of toxicity. Although, multiple factors can play a role in motor neuron degeneration, recent evidences point toward a fundamental role for RNA and RNA-binding protein dys-homeostasis as crucial players in ALS pathogenesis. Therefore, the overarching goal of ExItALS is to characterize the astrocyte-EVs RNA cargos, -through RNA deep-sequencing (Aim1). This approach will be complemented by the use of high-resolution flow cytometry (secondment) to separate EV populations and determine which one(s) is(are) responsible for motor neuron toxicity (Aim2). The present research proposal is a synthesis of my interests in neurodegenerative diseases and my expertise in biochemistry and neurobiology. At the Host Institution I will greatly benefit from the scientific exchange with several PIs interested in RNA biology, particularly with my supervisor, whose skills in RNA-binding protein biology and bioinformatics analyses will perfectly integrate and consolidate my molecular and biochemical expertise. The MSCA-RI-IF will be instrumental to develop this initial hypothesis into deeper biological understanding of ALS and represent a crucial support to my scientific integration as a competitive, woman investigator in the transition from a researcher position to an independent academic career.

 Publications

year authors and title journal last update
List of publications.
2016 Manuela Basso, Valentina Bonetto
Extracellular Vesicles and a Novel Form of Communication in the Brain
published pages: , ISSN: 1662-453X, DOI: 10.3389/fnins.2016.00127
Frontiers in Neuroscience 10 2019-11-20
2018 Deborah Ferrara, Laura Pasetto, Valentina Bonetto, Manuela Basso
Role of Extracellular Vesicles in Amyotrophic Lateral Sclerosis
published pages: , ISSN: 1662-453X, DOI: 10.3389/fnins.2018.00574
Frontiers in Neuroscience 12 2019-11-20

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