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RANdOM SIGNED

Systematic search of RegulAtory elements coNtrOlling autosomal Monoallelic expression

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 RANdOM project word cloud

Explore the words cloud of the RANdOM project. It provides you a very rough idea of what is the project "RANdOM" about.

consistently    cells    relative    successful    shed    computational    expression    strategy    molecular    regions    mclysaght    genomic    mouse    completion    character    researcher    gimelbrant    mammalian    tcd    skills    mechanistic    collaborating    map    establishment    maternal    evolution    list    fellowship    f1    context    matched    phenomenon    genetic    human    light    outgoing    collaborative    subject    complemented    unless    controls    clarified    crosses    consistent    strains    backgrounds    species    mice    developmental    prof    conserved    model    commensurate    regulatory    patterns    mae    differ    narrow    despite    divergent    loci    genes    autosomal    genome    emerge    epigenetic    doors    individuals    link    return    discover    chimp    laboratories    motifs    candidate    diverse    differences    experimentally    paternal    progress    alleles    mechanisms    supervision    thousands    first    monoallelic    systematic    mutagenesis    maintenance    dfci    shows    independent    conservation   

Project "RANdOM" data sheet

The following table provides information about the project.

Coordinator
THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN 

Organization address
address: College Green
city: DUBLIN
postcode: 2
website: www.tcd.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 248˙063 €
 EC max contribution 248˙063 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-GF
 Starting year 2018
 Duration (year-month-day) from 2018-01-01   to  2020-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN IE (DUBLIN) coordinator 248˙063.00
2    DANA-FARBER CANCER INSTITUTE INC US (BOSTON MA) partner 0.00

Map

 Project objective

Autosomal monoallelic expression (MAE) is an epigenetic phenomenon that controls the relative expression of maternal and paternal alleles in thousands of mammalian genes. Despite MAE’s widespread character the molecular mechanisms involved in its establishment and maintenance are yet to be clarified. Recent work shows that the sets of genes subject to MAE are highly consistent across individuals and conserved between human and mouse species. I propose to test that such conservation is due to specific regulatory elements in the genome associated with MAE genes. The strategy to discover such elements is via a systematic analysis of differences in genome-wide MAE patterns. In the outgoing phase of the Fellowship, I will be based in DFCI under the supervision of Prof. A. Gimelbrant. There, I will experimentally map MAE patterns in mice with highly divergent genomic backgrounds and identify loci that consistently differ between strains in whether they are MAE. Using computational methods, I will then determine whether particular motifs are associated with such variable regions. I will further assess the role of the candidate regulatory elements using specific F1 crosses and targeted mutagenesis. The analysis in the mouse will be complemented by comparative analysis of human and chimp matched cells, in order to narrow down the candidate loci list and shed light on the evolution of MAE. Successful completion of this project will establish the first model of genetic control of MAE and open doors to progress in the mechanistic and developmental understanding of MAE. On return to the TCD, under the supervision of Prof. A. McLysaght, I will be the link between two laboratories with a diverse research focus that would not be collaborating unless in the context of this Fellowship. I will emerge from this collaborative work with new skills commensurate with a leading independent researcher in the EU.

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