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MULTICELLEXPEVO TERMINATED

Reconstructing the origins of animal multicellularity using experimental evolution

Total Cost €

EC-Contrib. €

Partnership

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MULTICELLEXPEVO project word cloud

Explore the words cloud of the MULTICELLEXPEVO project. It provides you a very rough idea of what is the project "MULTICELLEXPEVO" about.

descended excessive obtain emergence genomics evolutionary altogether closely transition lineages capsaspora phylogenomic clade filastereans cell biologists phenotypic multicellular developmental advantage owczarzaki pivotal forming reveal screen fellowship unable filasterean cellular animal specification living cytoskeleton genetic strains unravel form biology aggregates stabilization all model organism holozoa appeared cycle choanoflagellates animals fate play minimum experimental showing actin ichthyosporeans emerged random celled single became unicellular ancestor morphology mutants first transient tools perspective questions combine stable mutagenesis evolution shown multicellularity stabilized

Project "MULTICELLEXPEVO" data sheet

The following table provides information about the project.

Coordinator	AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS Organization address address: CALLE SERRANO 117 city: MADRID postcode: 28006 website: http://www.csic.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Spain [ES]
Total cost	158˙121 €
EC max contribution	158˙121 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2016
Funding Scheme	MSCA-IF-EF-ST
Starting year	2018
Duration (year-month-day)	from 2018-09-01 to 2020-08-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS	ES (MADRID)	coordinator	158˙121.00

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Project objective

All living animals are descended from a single-celled ancestor. Understanding how this ancestor became the first multicellular animal remains a major challenge in the field of evolutionary biology. Phylogenomic analyses have shown that animals are closely related to three unicellular lineages: choanoflagellates, filastereans and ichthyosporeans, altogether forming the Holozoa clade. Genetic and phenotypic studies have shown that the filasterean Capsaspora owczarzaki can under specific growth conditions form transient multicellular aggregates. However, why is this multicellularity only transient? What are the genetic and phenotypic requirements for its emergence and stabilization? And what is the role of the actin cytoskeleton in this transition? Indeed the actin cytoskeleton is known for its pivotal role for cell coordination and morphology, which must play a role in evolution of multicellularity. To address these questions, we will use the C. owczarzaki as a model organism. We will combine cell biology, genomics and experimental evolution to unravel multicellularity emergence and stabilization. Specifically, we will aim to obtain evolved mutants showing excessive and more stable multicellular behaviour of C. owczarzaki using long-term experimental evolution. Such evolved strains would unravel how multicellularity emerged and stabilized. In addition, using random mutagenesis screen, we aim to identify mutants unable to form multicellular aggregates. Such mutants would reveal the minimum genetic requirements for such a transition. Finally, we will take advantage of recently developed genetic tools in C. owczarzaki to study the actin cytoskeleton during the cell cycle. Our results could reveal how the first multicellular ancestor of animals appeared from a genetic and cellular perspective, and, how cell fate specification was established during evolution. Results generated on this fellowship will be relevant to evolutionary, cell and developmental biologists.

Publications

List of publications.
year	authors and title	journal	last update
2019	Omaya Dudin, Andrej Ondracka, Xavier Grau-BovÃ©, Arthur AB Haraldsen, Atsushi Toyoda, Hiroshi Suga, Jon BrÃ¥te, IÃ±aki Ruiz-Trillo A unicellular relative of animals generates a layer of polarized cells by actomyosin-dependent cellularization published pages: , ISSN: 2050-084X, DOI: 10.7554/elife.49801	eLife 8	2020-03-03

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The information about "MULTICELLEXPEVO" are provided by the European Opendata Portal: CORDIS opendata.