Opendata, web and dolomites

LIPMETIN-sURFing SIGNED

Small open reading frames (smORF) as novel modulators of disorders of dietary excess

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 LIPMETIN-sURFing project word cloud

Explore the words cloud of the LIPMETIN-sURFing project. It provides you a very rough idea of what is the project "LIPMETIN-sURFing" about.

edge    last    diseases    metabolism    modulated    involve    conserved    frames    acid    microproteins    group    fewer    smorf    screens    screen    mediterranean    peptides    polyunsaturated    modulate    ribosome    cardiovascular    sheer    reading    sometimes    proof    intestine    hydroxytyrosol    completely    obscure    excess    amino    previously    peptidomics    therapeutic    cutting    profiling    nutrition    validate    small    difficulties    first    intellectual    translated    disease    functional    food    largely    components    proteins    detection    area    lipid    bioactive    2020    framed    mps    peptidomic    strategies    search    vitro    dha    fatty    dietary    merits    innovative    mechanism    diet    threefold    mortality    origin    players    genetic    omega    approximations    complete    regulate    bioinformatics    sequencing    health    suggest    framework    expression    healthy    function    union    unknown    intestinal    rna    vivo    genome    experimental    encoded    biotechnology    biochemical    horizon    amount    peptide    transcribed    disregarded    acids   

Project "LIPMETIN-sURFing" data sheet

The following table provides information about the project.

Coordinator
FUNDACION IMDEA ALIMENTACION 

Organization address
address: PABELLON CENTRAL DEL ANTIGUO HOSPITAL DE CANTOBLAN EDIFICIO NUMERO 7- CARRETERA MADRID- COLMENAR VIEJO--KILOMETRO 14
city: MADRID
postcode: 28049
website: http://www.food.imdea.org

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 257˙191 €
 EC max contribution 257˙191 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-GF
 Starting year 2018
 Duration (year-month-day) from 2018-01-15   to  2021-05-16

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACION IMDEA ALIMENTACION ES (MADRID) coordinator 257˙191.00
2    THE SALK INSTITUTE FOR BIOLOGICAL STUDIES US (LA JOLLA) partner 0.00

Map

 Project objective

Dietary excess is the major origin of cardiovascular diseases and remains the leading cause of mortality. Due to difficulties with bioinformatics detection and experimental analysis, along with their sheer numbers, small open reading frames (smORF) –of fewer than 100 amino acids– have been largely disregarded. Advances in bioinformatics, RNA-sequencing (ribosome profiling), biochemical (peptidomics) and functional (genetic) screens, suggest that a large amount of smORF are transcribed and sometimes widely conserved. However, how much of these smORF-encoded peptides or small proteins (microproteins (MPs)) are translated into a functional peptide is largely unknown. Moreover, whether food bioactive components modulate the expression of MPs remains complete obscure. Thus, the main goal of this project is to search for MPs that regulate lipid metabolism in the intestine in response to dietary excess. The intellectual merits of this proposal are threefold. First, it will use cutting-edge technology to search for novel functional MPs. Second, it will address a new group of novel potential players not previously addressed in lipid metabolism, providing a novel insight into disease mechanism and innovative therapeutic strategies. Last, by testing two common food bioactive components from our healthy Mediterranean diet, we will open up a completely new field of research in the area of nutrition and health. The research approach will involve (i) a genome-wide peptidomic screen and ribosome profiling analysis of lipid-induced intestinal MPs, (ii) the use of in vivo and in vitro biochemical approximations to validate the function of the selected intestinal peptide, and (iii) the use of dietary components hydroxytyrosol and the omega-3 polyunsaturated fatty acid DHA as proof of concept that MPs can be modulated by our diet food bioactive. This project is framed in the “Food & Healthy Diet and Biotechnology” research area in the European Union's Framework Programme HORIZON 2020

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "LIPMETIN-SURFING" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "LIPMETIN-SURFING" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

MultiSeaSpace (2019)

Developing a unified spatial modelling strategy that accounts for interactions between species at different marine trophic levels, and different types of survey data.

Read More  

Topo-circuit (2019)

Exploring topological phenomenon in RF circuits

Read More  

LIGHTMATT-EXPLORER (2019)

Experimental determination of the paraxial-vectorial limit of light-matter interactions

Read More