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LIPMETIN-sURFing SIGNED

Small open reading frames (smORF) as novel modulators of disorders of dietary excess

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 LIPMETIN-sURFing project word cloud

Explore the words cloud of the LIPMETIN-sURFing project. It provides you a very rough idea of what is the project "LIPMETIN-sURFing" about.

search    proof    screens    cutting    vivo    regulate    mortality    intellectual    transcribed    framework    nutrition    difficulties    screen    merits    lipid    detection    diseases    threefold    complete    mechanism    fatty    bioinformatics    peptide    peptidomic    area    genetic    validate    smorf    food    amount    health    union    peptides    microproteins    bioactive    unknown    frames    function    sometimes    approximations    vitro    experimental    omega    modulate    acids    innovative    profiling    framed    fewer    players    rna    intestine    largely    mps    intestinal    disregarded    proteins    strategies    sequencing    obscure    mediterranean    genome    suggest    2020    small    healthy    components    group    horizon    last    cardiovascular    first    biotechnology    acid    therapeutic    edge    translated    diet    amino    conserved    involve    origin    hydroxytyrosol    functional    completely    previously    sheer    disease    excess    metabolism    encoded    biochemical    expression    dietary    modulated    polyunsaturated    reading    ribosome    dha    peptidomics   

Project "LIPMETIN-sURFing" data sheet

The following table provides information about the project.

Coordinator		 FUNDACION IMDEA ALIMENTACION 

Organization address
address: PABELLON CENTRAL DEL ANTIGUO HOSPITAL DE CANTOBLAN EDIFICIO NUMERO 7- CARRETERA MADRID- COLMENAR VIEJO--KILOMETRO 14
city: MADRID
postcode: 28049
website: http://www.food.imdea.org

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Spain [ES]
 Total cost 257˙191 €
 EC max contribution 257˙191 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-GF
 Starting year 2018
 Duration (year-month-day) from 2018-01-15   to  2021-05-16

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACION IMDEA ALIMENTACION ES (MADRID) coordinator 257˙191.00
2    THE SALK INSTITUTE FOR BIOLOGICAL STUDIES US (LA JOLLA) partner 0.00

Map

 Project objective

Dietary excess is the major origin of cardiovascular diseases and remains the leading cause of mortality. Due to difficulties with bioinformatics detection and experimental analysis, along with their sheer numbers, small open reading frames (smORF) –of fewer than 100 amino acids– have been largely disregarded. Advances in bioinformatics, RNA-sequencing (ribosome profiling), biochemical (peptidomics) and functional (genetic) screens, suggest that a large amount of smORF are transcribed and sometimes widely conserved. However, how much of these smORF-encoded peptides or small proteins (microproteins (MPs)) are translated into a functional peptide is largely unknown. Moreover, whether food bioactive components modulate the expression of MPs remains complete obscure. Thus, the main goal of this project is to search for MPs that regulate lipid metabolism in the intestine in response to dietary excess. The intellectual merits of this proposal are threefold. First, it will use cutting-edge technology to search for novel functional MPs. Second, it will address a new group of novel potential players not previously addressed in lipid metabolism, providing a novel insight into disease mechanism and innovative therapeutic strategies. Last, by testing two common food bioactive components from our healthy Mediterranean diet, we will open up a completely new field of research in the area of nutrition and health. The research approach will involve (i) a genome-wide peptidomic screen and ribosome profiling analysis of lipid-induced intestinal MPs, (ii) the use of in vivo and in vitro biochemical approximations to validate the function of the selected intestinal peptide, and (iii) the use of dietary components hydroxytyrosol and the omega-3 polyunsaturated fatty acid DHA as proof of concept that MPs can be modulated by our diet food bioactive. This project is framed in the “Food & Healthy Diet and Biotechnology” research area in the European Union's Framework Programme HORIZON 2020

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