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Investigating how anaphase chromosomal motion is generated during mitosis and meiosis

Total Cost €


EC-Contrib. €






 ChromoDrive project word cloud

Explore the words cloud of the ChromoDrive project. It provides you a very rough idea of what is the project "ChromoDrive" about.

occurring    daughter    anaphase    organism    mitosis    germ    competent    genome    technically    poleward    mammalian    mechanisms    meiosis    microscopy    live    reproductive    protein    of    eggs    copies    techniques    defects    mechanism    hallmark    combination    confound    birth    candidate    mature    fertilised    implications    power    divide    phases    light    laser    somatic    separated    nature    conclusive    diseases    renewed    shed    genetic    onset    movement    underlying    mouse    validate    occurs    tissues    suggested    sperm    types    unclear    whilst    physically    clinical    obvious    egg    chromosome    microsurgery    spontaneous    underlie    disrupting    errors    cell    abortion    disorders    biological    fundamental    proteins    celled    fertilisation    century    mammals    cancer    optogenetics    transformed    oocytes    life    chromosomes    single    instability    function    resolution    tools    cells    equally    understand    division    inactivate   

Project "ChromoDrive" data sheet

The following table provides information about the project.


Organization address
address: RUA ALFREDO ALLEN 208
city: PORTO
postcode: 4200 135

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Portugal [PT]
 Project website
 Total cost 148˙635 €
 EC max contribution 148˙635 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-07-01   to  2019-06-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Cell division is a process essential for life. There are two types of cell division: meiosis and mitosis. Meiosis is a type of cell division specific to germ cells, allowing the formation of fertilisation-competent sperm and eggs. Mitosis allows a single-celled fertilised egg to develop into a mature organism, and also allows tissues to be renewed. During each cell division, the cell must divide two copies of the genome equally between two daughter cells. Errors that occur during this process in oocytes can lead to spontaneous abortion and birth defects, whilst errors occurring in somatic cells can lead to genetic instability, a hallmark of cancer. It is therefore essential to understand how this fundamental process occurs. The phase of cell division during which the chromosomes are physically separated is called anaphase. Although anaphase has been studied for more than a century, the mechanisms that underlie the poleward movement of chromosomes in mammals are still unclear. Several studies have suggested candidate proteins that may power their movement, but there were no conclusive results due to the technically challenging nature of this research. The main challenge is that one must efficiently inactivate the candidate protein(s) only at the onset of anaphase so as to avoid disrupting the previous phases of cell division, which could confound the results. Methods to rapidly inactivate proteins targets have only recently become available. Here, we propose to use these techniques to study the mechanism(s) underlying poleward chromosome movement during anaphase in both meiosis (mouse oocytes) and mitosis (non-transformed mammalian somatic cells). In both cases, we will validate the results using a combination of loss-of-function and optogenetics tools, high-resolution live-cell microscopy, and laser microsurgery. This work will shed light on a fundamental biological process with obvious clinical implications for diseases such as cancer and reproductive disorders.


year authors and title journal last update
List of publications.
2019 Olga Afonso, Colleen M Castellani, Liam P Cheeseman, Jorge G Ferreira, Bernardo Orr, Luisa T Ferreira, James J Chambers, Eurico Morais-de-Sá, Thomas J Maresca, Helder Maiato
Spatiotemporal control of mitotic exit during anaphase by an Aurora B-Cdk1 crosstalk
published pages: , ISSN: 2050-084X, DOI: 10.7554/elife.47646
eLife 8 2019-11-13

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