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ProFrost SIGNED

Theoretical and Numerical Analysis of Antifreeze and Ice Nucleator Proteins:Coarse-Grain Approach for Multiscale Study and Bio-Engineering

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 ProFrost project word cloud

Explore the words cloud of the ProFrost project. It provides you a very rough idea of what is the project "ProFrost" about.

computer    structural    frozen    spectrum    thermodynamic    influence    technological    review    pave    nucleator    dynamical    disciplines    simulations    nucleation    innovative    publications    atmospheric    influencing    follows    national    food    organisms    vega    antifreeze    adapt    search    afps    protein    solutions    interfaces    preservation    coluzza    interdisciplinary    carlos    tissues    scientific    combination    dr    attracts    multiple    dellago    nature    chemistry    combines    water    folding    cryo    offers    point    explore    line    pressures    proteins    environmental    science    functionalized    life    broad    subject    understand    deeply    temperatures    biophysical    academy    artificial    configurational    bio    journals    proceeding    ice    sequences    theoretical    inps    framework    molecules    space    grain    profrost    physics    physical    international    biology    excursions    prof    letters    rate    supervision    shelf    character    expert    coarse    model   

Project "ProFrost" data sheet

The following table provides information about the project.

Coordinator
UNIVERSIDAD COMPLUTENSE DE MADRID 

Organization address
address: AVENIDA DE SENECA 2
city: MADRID
postcode: 28040
website: http://www.ucm.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 158˙121 €
 EC max contribution 158˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-09-01   to  2020-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDAD COMPLUTENSE DE MADRID ES (MADRID) coordinator 158˙121.00

Map

 Project objective

In nature there are many organisms able to control the ice nucleation rate of water. This ability allows such organisms to adapt to environmental changes, like large temperatures excursions, and to facilitate the search for food. Bio-molecules such as antifreeze proteins (AFPs) and ice nucleator proteins (INPs) are known to influence the ice nucleation rate, a feature that attracts great interest from a wide spectrum of scientific disciplines like biology and atmospheric science, and it offers several technological applications like cryo-preservation of tissues and increasing frozen food shelf life. I propose a new approach, based on a novel combination of water-protein coarse-grain model, able, for a wide range of temperatures and pressures, to deeply explore the configurational space of a water-protein solutions. The ProFrost project aims at defining a novel theoretical framework within which it will be possible to study how the folding properties of AFPs and INPs affect the thermodynamic state point of water. The main goal of the project is to understand the influence of protein interfaces on the dynamical and structural properties of water. The success of this project will pave the way for the computer based design of artificial functionalized protein sequences capable of influencing the phase of water. This project follows an innovative research line, with a multi-scale approach that combines multiple fields of research, such as physics, biology and chemistry. This research due to its interdisciplinary character and broad interest, has large impact and is often subject of publications on relevant international scientific journals, such as Nature, Science, Proceeding of National Academy of Science, Physical Review Letters. ProFrost will carried out under the supervision Prof Carlos Vega, a leading expert on water, and in collaboration with Prof. Dellago and Dr. Coluzza, expert in modelling and simulations of biophysical systems,

 Publications

year authors and title journal last update
List of publications.
2018 Valentino Bianco, Emanuele Locatelli, Paolo Malgaretti
Globulelike Conformation and Enhanced Diffusion of Active Polymers
published pages: , ISSN: 0031-9007, DOI: 10.1103/physrevlett.121.217802
Physical Review Letters 121/21 2019-07-18

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The information about "PROFROST" are provided by the European Opendata Portal: CORDIS opendata.

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