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ProFrost SIGNED

Theoretical and Numerical Analysis of Antifreeze and Ice Nucleator Proteins:Coarse-Grain Approach for Multiscale Study and Bio-Engineering

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 ProFrost project word cloud

Explore the words cloud of the ProFrost project. It provides you a very rough idea of what is the project "ProFrost" about.

multiple    publications    point    search    nature    functionalized    structural    dynamical    national    review    configurational    protein    space    tissues    shelf    adapt    theoretical    chemistry    technological    simulations    vega    coluzza    explore    folding    understand    coarse    biophysical    influence    organisms    dellago    pressures    offers    water    nucleation    combination    physical    subject    follows    artificial    character    journals    influencing    prof    atmospheric    scientific    excursions    environmental    bio    supervision    computer    ice    afps    life    dr    rate    interdisciplinary    food    inps    model    solutions    antifreeze    expert    proceeding    disciplines    cryo    broad    physics    deeply    biology    profrost    sequences    letters    spectrum    pave    temperatures    international    framework    line    thermodynamic    carlos    molecules    academy    grain    combines    preservation    proteins    nucleator    attracts    interfaces    frozen    science    innovative   

Project "ProFrost" data sheet

The following table provides information about the project.

Coordinator
UNIVERSIDAD COMPLUTENSE DE MADRID 

Organization address
address: AVENIDA DE SENECA 2
city: MADRID
postcode: 28040
website: http://www.ucm.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 158˙121 €
 EC max contribution 158˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-09-01   to  2020-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDAD COMPLUTENSE DE MADRID ES (MADRID) coordinator 158˙121.00

Map

 Project objective

In nature there are many organisms able to control the ice nucleation rate of water. This ability allows such organisms to adapt to environmental changes, like large temperatures excursions, and to facilitate the search for food. Bio-molecules such as antifreeze proteins (AFPs) and ice nucleator proteins (INPs) are known to influence the ice nucleation rate, a feature that attracts great interest from a wide spectrum of scientific disciplines like biology and atmospheric science, and it offers several technological applications like cryo-preservation of tissues and increasing frozen food shelf life. I propose a new approach, based on a novel combination of water-protein coarse-grain model, able, for a wide range of temperatures and pressures, to deeply explore the configurational space of a water-protein solutions. The ProFrost project aims at defining a novel theoretical framework within which it will be possible to study how the folding properties of AFPs and INPs affect the thermodynamic state point of water. The main goal of the project is to understand the influence of protein interfaces on the dynamical and structural properties of water. The success of this project will pave the way for the computer based design of artificial functionalized protein sequences capable of influencing the phase of water. This project follows an innovative research line, with a multi-scale approach that combines multiple fields of research, such as physics, biology and chemistry. This research due to its interdisciplinary character and broad interest, has large impact and is often subject of publications on relevant international scientific journals, such as Nature, Science, Proceeding of National Academy of Science, Physical Review Letters. ProFrost will carried out under the supervision Prof Carlos Vega, a leading expert on water, and in collaboration with Prof. Dellago and Dr. Coluzza, expert in modelling and simulations of biophysical systems,

 Publications

year authors and title journal last update
List of publications.
2018 Valentino Bianco, Emanuele Locatelli, Paolo Malgaretti
Globulelike Conformation and Enhanced Diffusion of Active Polymers
published pages: , ISSN: 0031-9007, DOI: 10.1103/physrevlett.121.217802
Physical Review Letters 121/21 2019-07-18

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