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Theoretical and Numerical Analysis of Antifreeze and Ice Nucleator Proteins:Coarse-Grain Approach for Multiscale Study and Bio-Engineering

Total Cost €


EC-Contrib. €






 ProFrost project word cloud

Explore the words cloud of the ProFrost project. It provides you a very rough idea of what is the project "ProFrost" about.

nature    ice    frozen    excursions    tissues    adapt    scientific    physical    deeply    life    theoretical    shelf    expert    influence    space    pressures    spectrum    profrost    pave    configurational    influencing    broad    organisms    thermodynamic    science    carlos    character    search    dr    protein    artificial    simulations    attracts    coarse    offers    international    solutions    combines    coluzza    cryo    prof    vega    model    preservation    follows    framework    nucleation    nucleator    multiple    supervision    publications    functionalized    sequences    chemistry    grain    temperatures    bio    explore    molecules    antifreeze    journals    rate    proteins    innovative    computer    understand    physics    dynamical    water    interfaces    technological    biophysical    disciplines    letters    atmospheric    afps    combination    line    dellago    food    point    environmental    proceeding    academy    review    subject    biology    folding    national    interdisciplinary    inps    structural   

Project "ProFrost" data sheet

The following table provides information about the project.


Organization address
city: MADRID
postcode: 28040

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 158˙121 €
 EC max contribution 158˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-09-01   to  2020-08-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

In nature there are many organisms able to control the ice nucleation rate of water. This ability allows such organisms to adapt to environmental changes, like large temperatures excursions, and to facilitate the search for food. Bio-molecules such as antifreeze proteins (AFPs) and ice nucleator proteins (INPs) are known to influence the ice nucleation rate, a feature that attracts great interest from a wide spectrum of scientific disciplines like biology and atmospheric science, and it offers several technological applications like cryo-preservation of tissues and increasing frozen food shelf life. I propose a new approach, based on a novel combination of water-protein coarse-grain model, able, for a wide range of temperatures and pressures, to deeply explore the configurational space of a water-protein solutions. The ProFrost project aims at defining a novel theoretical framework within which it will be possible to study how the folding properties of AFPs and INPs affect the thermodynamic state point of water. The main goal of the project is to understand the influence of protein interfaces on the dynamical and structural properties of water. The success of this project will pave the way for the computer based design of artificial functionalized protein sequences capable of influencing the phase of water. This project follows an innovative research line, with a multi-scale approach that combines multiple fields of research, such as physics, biology and chemistry. This research due to its interdisciplinary character and broad interest, has large impact and is often subject of publications on relevant international scientific journals, such as Nature, Science, Proceeding of National Academy of Science, Physical Review Letters. ProFrost will carried out under the supervision Prof Carlos Vega, a leading expert on water, and in collaboration with Prof. Dellago and Dr. Coluzza, expert in modelling and simulations of biophysical systems,


year authors and title journal last update
List of publications.
2018 Valentino Bianco, Emanuele Locatelli, Paolo Malgaretti
Globulelike Conformation and Enhanced Diffusion of Active Polymers
published pages: , ISSN: 0031-9007, DOI: 10.1103/physrevlett.121.217802
Physical Review Letters 121/21 2019-07-18

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The information about "PROFROST" are provided by the European Opendata Portal: CORDIS opendata.

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