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ProFrost SIGNED

Theoretical and Numerical Analysis of Antifreeze and Ice Nucleator Proteins:Coarse-Grain Approach for Multiscale Study and Bio-Engineering

Total Cost €

EC-Contrib. €

Partnership

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ProFrost project word cloud

Explore the words cloud of the ProFrost project. It provides you a very rough idea of what is the project "ProFrost" about.

life nature afps dellago artificial physics disciplines protein theoretical follows molecules bio pressures national expert functionalized interfaces proceeding explore antifreeze ice thermodynamic vega innovative nucleator dr proteins search excursions coluzza temperatures frozen prof biology international sequences influencing nucleation carlos preservation spectrum grain attracts influence shelf line computer atmospheric academy physical point food journals combines cryo offers simulations character broad chemistry adapt space coarse science understand dynamical solutions profrost review supervision model framework publications pave deeply biophysical structural interdisciplinary folding subject inps water combination multiple tissues letters environmental technological configurational organisms scientific rate

Project "ProFrost" data sheet

The following table provides information about the project.

Coordinator	UNIVERSIDAD COMPLUTENSE DE MADRID Organization address address: AVENIDA DE SENECA 2 city: MADRID postcode: 28040 website: http://www.ucm.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Spain [ES]
Total cost	158˙121 €
EC max contribution	158˙121 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2016
Funding Scheme	MSCA-IF-EF-ST
Starting year	2018
Duration (year-month-day)	from 2018-09-01 to 2020-08-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSIDAD COMPLUTENSE DE MADRID UNIVERSIDAD COMPLUTENSE DE MADRID Organization address address: AVENIDA DE SENECA 2 city: MADRID postcode: 28040 website: http://www.ucm.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (MADRID)	coordinator	158˙121.00

Map

Project objective

In nature there are many organisms able to control the ice nucleation rate of water. This ability allows such organisms to adapt to environmental changes, like large temperatures excursions, and to facilitate the search for food. Bio-molecules such as antifreeze proteins (AFPs) and ice nucleator proteins (INPs) are known to influence the ice nucleation rate, a feature that attracts great interest from a wide spectrum of scientific disciplines like biology and atmospheric science, and it offers several technological applications like cryo-preservation of tissues and increasing frozen food shelf life. I propose a new approach, based on a novel combination of water-protein coarse-grain model, able, for a wide range of temperatures and pressures, to deeply explore the configurational space of a water-protein solutions. The ProFrost project aims at defining a novel theoretical framework within which it will be possible to study how the folding properties of AFPs and INPs affect the thermodynamic state point of water. The main goal of the project is to understand the influence of protein interfaces on the dynamical and structural properties of water. The success of this project will pave the way for the computer based design of artificial functionalized protein sequences capable of influencing the phase of water. This project follows an innovative research line, with a multi-scale approach that combines multiple fields of research, such as physics, biology and chemistry. This research due to its interdisciplinary character and broad interest, has large impact and is often subject of publications on relevant international scientific journals, such as Nature, Science, Proceeding of National Academy of Science, Physical Review Letters. ProFrost will carried out under the supervision Prof Carlos Vega, a leading expert on water, and in collaboration with Prof. Dellago and Dr. Coluzza, expert in modelling and simulations of biophysical systems,

Publications

List of publications.
year	authors and title	journal	last update
2018	Valentino Bianco, Emanuele Locatelli, Paolo Malgaretti Globulelike Conformation and Enhanced Diffusion of Active Polymers published pages: , ISSN: 0031-9007, DOI: 10.1103/physrevlett.121.217802	Physical Review Letters 121/21	2019-07-18

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The information about "PROFROST" are provided by the European Opendata Portal: CORDIS opendata.