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FOUNDATION SIGNED

Fusarium oxysporum mediated underpinning of cell type-specific modulation in multiple host interaction

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 FOUNDATION project word cloud

Explore the words cloud of the FOUNDATION project. It provides you a very rough idea of what is the project "FOUNDATION" about.

worldwide    borne    dicot    architecture    enormous    agricultural    root    remodelling    combined    dicots    banana    ongoing    action    colonizes    crop    contaminating    signals    arabidopsis    little    vessels    identification    aggressive    provides    colonization    fungal    pathogens    coupled    components    wall    devastating    lcm    fungi    efforts    rna    plant    plants    monocot    reported    pathogen    uses    wilt    tropical    seq    enzymes    infection    chemotrophic    harmful    host    disease    broad    threatening    nutrition    virulence    interaction    contributes    dissecting    crops    group    breeding    xylem    resolution    dual    penetration    revealed    characterization    perceived    fundamentally    infects    genes    fusarium    oxysporum    excellent    suppression    cell    fundamental    colonize    immunity    monocots    stages    sensing    degradation    causing    versus    core    biotrophic    microdissection    resistance    compatibility    protection    hundred    strain    establishing    tissue    losses    capture    mechanism    human    provoke    laser    fungus    model    health    strategies    senses    food    race    plantations    stage    soil    mycotoxins    vascular   

Project "FOUNDATION" data sheet

The following table provides information about the project.

Coordinator
UNIVERSIDAD DE CORDOBA 

Organization address
address: AVENIDA DE MEDINA AZAHARA 5
city: CORDOBA
postcode: 14005
website: www.uco.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 170˙121 €
 EC max contribution 170˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-07-01   to  2020-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDAD DE CORDOBA ES (CORDOBA) coordinator 170˙121.00

Map

 Project objective

Fungi have a devastating impact on human nutrition and health. Each year, fungal pathogens provoke enormous agricultural losses in crop plants and contaminating food with harmful mycotoxins. The soil-borne fungal pathogen Fusarium oxysporum infects plant root and vascular tissue, causing wilt disease in over a hundred different crops, including both dicots and monocots. A particular aggressive strain of this pathogen, tropical race 4, is threatening banana plantations worldwide. Currently, there is little information on the crucial biotrophic infection stage of vascular pathogens, from penetration of root to colonization of xylem vessels. Fusarium provides an excellent model to investigate the cell-specific sensing and adaptation and suppression of plant immunity related to early infection stages. The host group has recently reported the chemotrophic sensing mechanism used by this pathogen, and identified host plant signals perceived by Fusarium in the soil. Moreover, their work revealed a combined action of enzymes involved in fungal cell wall remodelling and plant cell wall degradation which contributes in virulence of this pathogen. In this project, we aim to identify the cell-specific virulence genes that F. oxysporum uses to colonize a dicot host (Arabidopsis) versus monocot (Banana) that has a fundamentally distinct vascular tissue architecture. We will use dual RNA-Seq coupled with Laser capture microdissection (LCM) to identify core compatibility components in both the pathogen and the plant, that are essential for establishing wilt disease. This will lead to identification and characterization of potential targets in this interaction that could be used to develop novel resistance strategies in ongoing banana breeding efforts. This project will thus advance fundamental knowledge of how a fungus senses and colonizes such a broad host range, while creating new opportunities for crop protection by dissecting the interaction at a cell-type specific resolution.

 Publications

year authors and title journal last update
List of publications.
2018 Pingtao Ding, Amey Redkar
Pathogens Suppress Host Transcription Factors for Rampant Proliferation
published pages: , ISSN: 1360-1385, DOI: 10.1016/j.tplants.2018.08.010
Trends in Plant Science 2019-05-29

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