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FOUNDATION SIGNED

Fusarium oxysporum mediated underpinning of cell type-specific modulation in multiple host interaction

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 FOUNDATION project word cloud

Explore the words cloud of the FOUNDATION project. It provides you a very rough idea of what is the project "FOUNDATION" about.

establishing    combined    core    crops    revealed    reported    senses    threatening    contaminating    colonization    versus    lcm    seq    model    efforts    fundamentally    aggressive    fusarium    oxysporum    characterization    plant    dicot    arabidopsis    protection    enzymes    rna    disease    wall    colonizes    sensing    infection    agricultural    host    health    coupled    colonize    laser    race    root    penetration    resistance    human    dicots    worldwide    broad    provides    breeding    provoke    uses    cell    vascular    pathogens    harmful    biotrophic    plants    enormous    tropical    dual    stage    excellent    dissecting    devastating    food    resolution    chemotrophic    ongoing    mechanism    soil    action    xylem    causing    signals    losses    interaction    suppression    compatibility    contributes    plantations    pathogen    strategies    nutrition    tissue    microdissection    vessels    immunity    fungus    banana    little    fundamental    genes    capture    identification    degradation    wilt    group    monocot    hundred    mycotoxins    components    architecture    remodelling    crop    borne    virulence    monocots    strain    fungal    perceived    stages    fungi    infects   

Project "FOUNDATION" data sheet

The following table provides information about the project.

Coordinator
UNIVERSIDAD DE CORDOBA 

Organization address
address: AVENIDA DE MEDINA AZAHARA 5
city: CORDOBA
postcode: 14005
website: www.uco.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 170˙121 €
 EC max contribution 170˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-07-01   to  2020-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDAD DE CORDOBA ES (CORDOBA) coordinator 170˙121.00

Map

 Project objective

Fungi have a devastating impact on human nutrition and health. Each year, fungal pathogens provoke enormous agricultural losses in crop plants and contaminating food with harmful mycotoxins. The soil-borne fungal pathogen Fusarium oxysporum infects plant root and vascular tissue, causing wilt disease in over a hundred different crops, including both dicots and monocots. A particular aggressive strain of this pathogen, tropical race 4, is threatening banana plantations worldwide. Currently, there is little information on the crucial biotrophic infection stage of vascular pathogens, from penetration of root to colonization of xylem vessels. Fusarium provides an excellent model to investigate the cell-specific sensing and adaptation and suppression of plant immunity related to early infection stages. The host group has recently reported the chemotrophic sensing mechanism used by this pathogen, and identified host plant signals perceived by Fusarium in the soil. Moreover, their work revealed a combined action of enzymes involved in fungal cell wall remodelling and plant cell wall degradation which contributes in virulence of this pathogen. In this project, we aim to identify the cell-specific virulence genes that F. oxysporum uses to colonize a dicot host (Arabidopsis) versus monocot (Banana) that has a fundamentally distinct vascular tissue architecture. We will use dual RNA-Seq coupled with Laser capture microdissection (LCM) to identify core compatibility components in both the pathogen and the plant, that are essential for establishing wilt disease. This will lead to identification and characterization of potential targets in this interaction that could be used to develop novel resistance strategies in ongoing banana breeding efforts. This project will thus advance fundamental knowledge of how a fungus senses and colonizes such a broad host range, while creating new opportunities for crop protection by dissecting the interaction at a cell-type specific resolution.

 Publications

year authors and title journal last update
List of publications.
2018 Pingtao Ding, Amey Redkar
Pathogens Suppress Host Transcription Factors for Rampant Proliferation
published pages: , ISSN: 1360-1385, DOI: 10.1016/j.tplants.2018.08.010
Trends in Plant Science 2019-05-29

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