Explore the words cloud of the MicroCONtACT project. It provides you a very rough idea of what is the project "MicroCONtACT" about.
The following table provides information about the project.
INSTITUTE OF EXPERIMENTAL MEDICINE - HUNGARIAN ACADEMY OF SCIENCES
|Coordinator Country||Hungary [HU]|
|Total cost||2˙000˙000 €|
|EC max contribution||2˙000˙000 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2017-04-01 to 2022-03-31|
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|1||INSTITUTE OF EXPERIMENTAL MEDICINE - HUNGARIAN ACADEMY OF SCIENCES||HU (Budapest)||coordinator||2˙000˙000.00|
Microglia are the main immune cells of the brain, but their role in brain injury is highly controversial due to the difficulties in selectively manipulating and imaging microglial actions in real time. Specifically, it is unclear whether microglia control neuronal survival after injury via shaping the activity of complex neuronal networks in vivo. To this end, we have combined fast in vivo two-photon imaging of neuronal calcium responses with selective microglial manipulation for the first time. Our data suggest that microglia constantly monitor and control neuronal network activity and these actions are essential to limit excitotoxicity and neuronal death after acute brain injury. We also identify microglia as key regulators of spreading depolarization in vivo. However, the underlying mechanisms remained unexplored. Here, I propose that microglia control neuronal excitability and based on preliminary data I set out to investigate how this occurs. We will combine selective, CSF1R-mediated microglia depletion with advanced neurophysiological methods such as in vivo calcium imaging and intracranial EEG for the first time, to reveal how microglia shape activity of complex neuronal networks in the healthy and the injured brain. Then, we will study microglia-neuron interactions from the network level to nanoscale level using in vivo two-photon imaging and super-resolution microscopy. We will apply novel chemogenic and optogenetic approaches to manipulate microglia in real time, assess their role in neuronal activity changes and investigate the molecular mechanisms in vitro and in vivo. Our unpublished data also suggest that inflammation – a key contributor to brain diseases – could disrupt microglia-neuron signaling and we set out to investigate the underlying mechanisms. By using state-of the-art research tools that had not been applied previously in this context, our studies are likely to reveal novel pathophysiological mechanisms relevant for common brain diseases.
|year||authors and title||journal||last update|
DÃ¡niel P Varga, Ãkos MenyhÃ¡rt, BalÃ¡zs PÃ³sfai, Eszter CsÃ¡szÃ¡r, Nikolett LÃ©nÃ¡rt, Csaba CserÃ©p, Barbara Orsolits, Bernadett Martinecz, TamÃ¡s SzlepÃ¡k, Ferenc Bari, Eszter Farkas, ÃdÃ¡m DÃ©nes
Microglia alter the threshold of spreading depolarization and related potassium uptake in the mouse brain
published pages: 0271678X1990009, ISSN: 0271-678X, DOI: 10.1177/0271678x19900097
|Journal of Cerebral Blood Flow & Metabolism||2020-04-07|
Csaba CserÃ©p, BalÃ¡zs PÃ³sfai, Nikolett LÃ©nÃ¡rt, Rebeka Fekete, ZsÃ³fia I. LÃ¡szlÃ³, Zsolt Lele, Barbara Orsolits, GÃ¡bor MolnÃ¡r, Steffanie Heindl, Anett D. Schwarcz, Katinka UjvÃ¡ri, Zsuzsanna KÃ¶rnyei, Krisztina TÃ³th, Eszter Szabadits, BeÃ¡ta SperlÃ¡gh, MÃ¡ria Baranyi, LÃ¡szlÃ³ Csiba, Tibor HortobÃ¡gyi, ZsÃ³fia MaglÃ³czky, Bernadett Martinecz, GÃ¡bor SzabÃ³, Ferenc ErdÃ©lyi, RÃ³bert SzipÅ‘cs
Microglia monitor and protect neuronal function through specialized somatic purinergic junctions
published pages: 528-537, ISSN: 0036-8075, DOI: 10.1126/science.aax6752
Csaba CserÃ©p, BalÃ¡zs PÃ³sfai, Barbara Orsolits, GÃ¡bor MolnÃ¡r, Steffanie Heindl, Nikolett LÃ©nÃ¡rt, Rebeka Fekete, ZsÃ³fia I. LÃ¡szlÃ³, Zsolt Lele, Anett D. Schwarcz, Katinka UjvÃ¡ri, LÃ¡szlÃ³ Csiba, Tibor HortobÃ¡gyi, ZsÃ³fia MaglÃ³czky, Bernadett Martinecz, GÃ¡bor SzabÃ³, Ferenc ErdÃ©lyi, RÃ³bert SzipÅ‘cs, Benno Gesierich, Marco Duering, IstvÃ¡n Katona, Arthur Liesz, GÃ¡bor TamÃ¡s, ÃdÃ¡m DÃ©
Microglia monitor and protect neuronal function via specialized somatic purinergic junctions
published pages: , ISSN: , DOI: 10.1101/606079
|bioRxiv.org - the preprint server for Biology||2019-10-15|
Zsuzsanna Helyes, ValÃ©ria TÃ©kus, Nikolett Szentes, Krisztina PohÃ³czky, BÃ¡lint Botz, TamÃ¡s Kiss, Ãgnes KemÃ©ny, Zsuzsanna KÃ¶rnyei, Krisztina TÃ³th, Nikolett LÃ©nÃ¡rt, Hajnalka ÃbrahÃ¡m, Emmanuel Pinteaux, Sheila Francis, Serena Sensi, ÃdÃ¡m DÃ©nes, Andreas Goebel
Transfer of complex regional pain syndrome to mice via human autoantibodies is mediated by interleukin-1â€“induced mechanisms
published pages: 13067-13076, ISSN: 0027-8424, DOI: 10.1073/pnas.1820168116
|Proceedings of the National Academy of Sciences 116/26||2019-10-07|
Lilla Lenart, Dora B. Balogh, Nikolett Lenart, Adrienn Barczi, Adam Hosszu, Tamas Farkas, Judit Hodrea, Attila J. Szabo, Krisztian Szigeti, Adam Denes, Andrea Fekete
Novel therapeutic potential of angiotensin receptor 1 blockade in a rat model of diabetes-associated depression parallels altered BDNF signalling
published pages: 1501-1513, ISSN: 0012-186X, DOI: 10.1007/s00125-019-4888-z
Kelly L. Singel, Kassondra S. Grzankowski, A. N. M. Nazmul H. Khan, Melissa J. Grimm, Anthony C. Dâ€™Auria, Kayla Morrell, Kevin H. Eng, Bonnie Hylander, Paul C. Mayor, Tiffany R. Emmons, Nikolett LÃ©nÃ¡rt, Rebeka Fekete, Zsuzsanna KÃ¶rnyei, Uma Muthukrishnan, Jonathan D. Gilthorpe, Constantin F. Urban, Kiyoshi Itagaki, Carl J. Hauser, Cynthia Leifer, Kirsten B. Moysich, Kunle Odunsi, ÃdÃ¡m DÃ©ne
Mitochondrial DNA in the tumour microenvironment activates neutrophils and is associated with worse outcomes in patients with advanced epithelial ovarian cancer
published pages: 207-217, ISSN: 0007-0920, DOI: 10.1038/s41416-018-0339-8
|British Journal of Cancer 120/2||2019-10-07|
Gergely KovÃ¡cs, Zsuzsanna KÃ¶rnyei, Krisztina TÃ³th, MÃ¡ria Baranyi, JÃ¡nos Brunner, MÃ¡tÃ© Neubrandt, ÃdÃ¡m DÃ©nes, BeÃ¡ta SperlÃ¡gh
Modulation of P2X7 purinergic receptor activity by extracellular Zn2+ in cultured mouse hippocampal astroglia
published pages: 1-13, ISSN: 0143-4160, DOI: 10.1016/j.ceca.2018.07.010
|Cell Calcium 75||2019-10-07|
CserÃ©p, Csaba; PÃ³sfai, BalÃ¡zs; Schwarcz, Anett DÃ³ra; DÃ©nes, ÃdÃ¡m
Mitochondrial Ultrastructure Is Coupled to Synaptic Performance at Axonal Release Sites
published pages: , ISSN: 2373-2822, DOI: 10.1101/216093
Rebeka Fekete, Csaba CserÃ©p, Nikolett LÃ©nÃ¡rt, Krisztina TÃ³th, Barbara Orsolits, Bernadett Martinecz, ElÅ‘d MÃ©hes, BÃ¡lint SzabÃ³, ValÃ©ria NÃ©meth, BalÃ¡zs GÃ¶nci, BeÃ¡ta SperlÃ¡gh, Zsolt BoldogkÅ‘i, Ãgnes Kittel, MÃ¡ria Baranyi, SzilamÃ©r Ferenczi, Krisztina KovÃ¡cs, Gergely Szalay, BalÃ¡zs RÃ³zsa, Connor Webb, Gabor G. Kovacs, Tibor HortobÃ¡gyi, Brian L. West, Zsuzsanna KÃ¶rnyei, ÃdÃ¡m DÃ©nes
Microglia control the spread of neurotropic virus infection via P2Y12 signalling and recruit monocytes through P2Y12-independent mechanisms
published pages: 461-482, ISSN: 0001-6322, DOI: 10.1007/s00401-018-1885-0
|Acta Neuropathologica 136/3||2019-04-18|
VirÃ¡g T. TakÃ¡cs, Csaba CserÃ©p, DÃ¡niel Schlingloff, BalÃ¡zs PÃ³sfai, AndrÃ¡s SzÅ‘nyi, Katalin E. Sos, Zsuzsanna KÃ¶rnyei, ÃdÃ¡m DÃ©nes, Attila I. GulyÃ¡s, TamÃ¡s F. Freund, GÃ¡bor Nyiri
Co-transmission of acetylcholine and GABA regulates hippocampal states
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-05136-1
|Nature Communications 9/1||2019-04-18|
BalÃ¡zs PÃ³sfai, Csaba CserÃ©p, Barbara Orsolits, ÃdÃ¡m DÃ©nes
New Insights into Microgliaâ€“Neuron Interactions: A Neuronâ€™s Perspective
published pages: , ISSN: 0306-4522, DOI: 10.1016/j.neuroscience.2018.04.046
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