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REBUILD

Mechanisms of sarcomeric protein homeostasis during physical exercise and ageing

Total Cost €

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EC-Contrib. €

0

Partnership

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 REBUILD project word cloud

Explore the words cloud of the REBUILD project. It provides you a very rough idea of what is the project "REBUILD" about.

power    turnover    driving    nature    francisco    independence    biomechanics    quantify    mass    population    animal    degenerate    leads    constantly    orientated    screen    dynamics    crossroads    muscle    stress    silac    ing    scientific    force    delay    proteins    physical    precise    san    life    progressive    developmental    free    interventions    consequence    health    protein    biomechanical    physiological    tissue    training    genetic    western    integrate    benefit    capacity    mechanisms    biology    healthy    proteomics    candidate    quantitative    genetics    acquired    accurately    suboptimal    decline    ageing    damaged    expertise    dynamic    flight    expand    rebuild    establishing    mechanical    position    movements    fibers    researcher    forces    ultimately    elderly    generation    maintenance    coordinated    individuals    homeostasis    interdisciplinary    usa    fiber    line    stone    lack    homeostatic    vivo    stepping    older    host    regulation    replacement    subjected    create    exercise    hypothesis    society    spectrometry    combining    temporal    during    cells    function    discovery   

Project "REBUILD" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Project website http://muscledynamics.org/
 Total cost 185˙076 €
 EC max contribution 141˙203 € (76%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-04-01   to  2019-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 141˙203.00

Map

 Project objective

During ageing muscle fibers are constantly subjected to high forces resulting in mechanical stress on cells and proteins. As a consequence they can degenerate, leading to suboptimal force generation, lack of coordinated movements and ultimately to muscle failure in the elderly population. This ageing process that leads to a progressive loss of muscle function has a major health impact on the ageing Western society. Physical activity is known to delay this decline.

The REBUILD project aims to determine the temporal dynamics of protein replacement during life of a muscle fiber by SILAC-based mass spectrometry and genetics. It will integrate biomechanics with muscle homeostasis and accurately quantify the impact of physical activity on protein turnover and investigate the physiological consequences for the ageing animal. By combining the power of genetics and SILAC-based proteomics with behaviour of free flight under defined exercise conditions, we create a unique position for a discovery orientated large-scale in vivo genetic screen. The interdisciplinary nature of the project will allow establishing novel hypothesis, combining muscle biomechanics as a driving force behind dynamic maintenance of the muscle tissue during ageing.

The experienced researcher will expand on previous training acquired in San Francisco, USA, and establish a new line of research in the crossroads of two developing fields (quantitative proteomics and biomechanical regulation of tissue homeostasis). This will be a stepping stone for his scientific independence. The host will expand on its expertise on developmental regulation of muscle formation and benefit from the expertise of the candidate in the biology of ageing and homeostasis.

A precise understanding of mechanisms that control homeostatic replacement of damaged proteins in muscle fibers should foster interventions aimed at maintenance of muscle capacity in older individuals and thus, an important step towards healthy ageing.

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The information about "REBUILD" are provided by the European Opendata Portal: CORDIS opendata.

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