Opendata, web and dolomites


Live, In vivo Visualisation of liver Regeneration in Zebrafish After Photoablation of hepatocytes

Total Cost €


EC-Contrib. €






 LIVERZAP project word cloud

Explore the words cloud of the LIVERZAP project. It provides you a very rough idea of what is the project "LIVERZAP" about.

map    regenerating    protocol    zebrafish    dynamic    vivo    body    scarring    community    tissue    driving    damaged    functions    rearrangement    transparency    edge    pathologies    monitoring    excellent    insights    restoration    deep    fellow    capacity    host    rapid    cell    opacity    techniques    environment    surface    human    specialised    crucially    chronic    larval    proteomics    outcomes    combined    tools    vital    treatment    ablation    live    static    regeneration    realise    location    whereas    regenerative    optogenetics    suited    competencies    molecular    silac    compromised    screened    position    liverzap    organ    metabolic    time    histological    mechanisms    hepatocyte    cellular    fixed    photoactivatable    expertise    liver    transplantation    generate    photon    platform    hindered    therapies    restore    imaging    species    limited    cutting    architecture    uniquely    disease    lost    mammalian    cirrhosis    temporally    microscopy    behaviours    injury    remodelling    pioneering    generating   

Project "LIVERZAP" data sheet

The following table provides information about the project.


Organization address
address: NORREGADE 10
postcode: 1165

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 200˙194 €
 EC max contribution 200˙194 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-01-01   to  2019-12-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) coordinator 200˙194.00


 Project objective

The specialised tissue architecture of the liver is crucially important for its essential metabolic functions in the body. The liver has the unique regenerative capacity to restore lost architecture when damaged. However, this remodelling process is compromised in chronic liver disease by scarring and cirrhosis. Often the only treatment is organ transplantation, thus the development of novel therapies is of vital importance. The necessary understanding of the dynamic cell rearrangement driving restoration of liver architecture has been limited by temporally static histological analyses of fixed regenerating tissue. Real-time monitoring of the mammalian liver is hindered by tissue opacity and deep organ position, whereas the surface location of the zebrafish liver and larval transparency makes this species uniquely suited for live, in vivo imaging of regeneration. LIVERZAP will generate a detailed map of the different cell behaviours driving restoration of liver architecture by pioneering real-time, in vivo imaging of regeneration in zebrafish. This will be achieved by: i) generating a novel, photoactivatable method for rapid hepatocyte ablation and ii) developing a deep tissue, 2-photon microscopy live imaging protocol. The molecular factors controlling the identified cell behaviours will be screened for using SILAC-based proteomics. To realise LIVERZAP, expertise in liver research, deep tissue microscopy and proteomics within the host environment will be combined with the fellow’s live imaging experience. LIVERZAP will generate excellent new tools for the regeneration community and greatly enhance the fellow’s competencies in specialised techniques, including cutting-edge microscopy systems and optogenetics. The outcomes of LIVERZAP will produce essential insights into the cellular and molecular mechanisms driving restoration of liver architecture following injury, providing a platform for the long-term development of therapies for human liver pathologies.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "LIVERZAP" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email ( and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "LIVERZAP" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

TIPTOP (2019)

Tensoring Positive Maps on Operator Structures

Read More  

NaWaTL (2020)

Narrative, Writing, and the Teotihuacan Language: Exploring Language History Through Phylogenetics, Epigraphy and Iconography

Read More  

PNAIC (2018)

Positive and Negative Asymmetry in Intergroup Contact: Its Impact on Linguistic Forms of Communication and Physiological Responses

Read More