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LIVERZAP TERMINATED

Live, In vivo Visualisation of liver Regeneration in Zebrafish After Photoablation of hepatocytes

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 LIVERZAP project word cloud

Explore the words cloud of the LIVERZAP project. It provides you a very rough idea of what is the project "LIVERZAP" about.

generate    imaging    environment    cellular    opacity    insights    deep    ablation    optogenetics    photoactivatable    uniquely    liverzap    rearrangement    community    map    therapies    hepatocyte    lost    generating    combined    hindered    treatment    metabolic    location    pathologies    organ    restoration    competencies    protocol    suited    rapid    outcomes    chronic    capacity    limited    human    histological    static    vivo    techniques    surface    tissue    functions    compromised    scarring    position    fellow    live    regenerative    restore    platform    molecular    proteomics    screened    host    mechanisms    driving    remodelling    regeneration    pioneering    vital    expertise    excellent    larval    transplantation    body    dynamic    microscopy    zebrafish    monitoring    regenerating    cutting    cell    cirrhosis    fixed    whereas    tools    mammalian    temporally    silac    crucially    damaged    injury    photon    species    edge    disease    liver    behaviours    transparency    realise    specialised    time    architecture   

Project "LIVERZAP" data sheet

The following table provides information about the project.

Coordinator
KOBENHAVNS UNIVERSITET 

Organization address
address: NORREGADE 10
city: KOBENHAVN
postcode: 1165
website: www.ku.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 200˙194 €
 EC max contribution 200˙194 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-01-01   to  2019-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) coordinator 200˙194.00

Map

 Project objective

The specialised tissue architecture of the liver is crucially important for its essential metabolic functions in the body. The liver has the unique regenerative capacity to restore lost architecture when damaged. However, this remodelling process is compromised in chronic liver disease by scarring and cirrhosis. Often the only treatment is organ transplantation, thus the development of novel therapies is of vital importance. The necessary understanding of the dynamic cell rearrangement driving restoration of liver architecture has been limited by temporally static histological analyses of fixed regenerating tissue. Real-time monitoring of the mammalian liver is hindered by tissue opacity and deep organ position, whereas the surface location of the zebrafish liver and larval transparency makes this species uniquely suited for live, in vivo imaging of regeneration. LIVERZAP will generate a detailed map of the different cell behaviours driving restoration of liver architecture by pioneering real-time, in vivo imaging of regeneration in zebrafish. This will be achieved by: i) generating a novel, photoactivatable method for rapid hepatocyte ablation and ii) developing a deep tissue, 2-photon microscopy live imaging protocol. The molecular factors controlling the identified cell behaviours will be screened for using SILAC-based proteomics. To realise LIVERZAP, expertise in liver research, deep tissue microscopy and proteomics within the host environment will be combined with the fellow’s live imaging experience. LIVERZAP will generate excellent new tools for the regeneration community and greatly enhance the fellow’s competencies in specialised techniques, including cutting-edge microscopy systems and optogenetics. The outcomes of LIVERZAP will produce essential insights into the cellular and molecular mechanisms driving restoration of liver architecture following injury, providing a platform for the long-term development of therapies for human liver pathologies.

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The information about "LIVERZAP" are provided by the European Opendata Portal: CORDIS opendata.

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