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PIGSs SIGNED

Program for Innovative Global Prevention of Streptococcus suis.

Total Cost €

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EC-Contrib. €

0

Partnership

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Project "PIGSs" data sheet

The following table provides information about the project.

Coordinator
WAGENINGEN UNIVERSITY 

Organization address
address: DROEVENDAALSESTEEG 4
city: WAGENINGEN
postcode: 6708 PB
website: http://www.wageningenur.nl/nl.htm

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Project website https://www.pigss-horizon2020.eu
 Total cost 4˙998˙103 €
 EC max contribution 4˙998˙103 € (100%)
 Programme 1. H2020-EU.3.2.1.1. (Increasing production efficiency and coping with climate change, while ensuring sustainability and resilience)
 Code Call H2020-SFS-2016-2
 Funding Scheme RIA
 Starting year 2017
 Duration (year-month-day) from 2017-06-01   to  2021-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    WAGENINGEN UNIVERSITY NL (WAGENINGEN) coordinator 1˙153˙795.00
2    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) participant 1˙030˙667.00
3    STICHTING WAGENINGEN RESEARCH NL (WAGENINGEN) participant 799˙998.00
4    INSTITUT DE RECERCA I TECNOLOGIA AGROALIMENTARIES ES (CALDES DE MONTBUI BARCELONA) participant 698˙981.00
5    STIFTUNG TIERAERZTLICHE HOCHSCHULE HANNOVER DE (HANNOVER) participant 408˙000.00
6    ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM NL (AMSTERDAM) participant 365˙146.00
7    DANMARKS TEKNISKE UNIVERSITET DK (KGS LYNGBY) participant 292˙765.00
8    CEVA SANTE ANIMALE SA FR (LIBOURNE) participant 150˙625.00
9    CHR. HANSEN A/S DK (HOERSHOLM) participant 98˙125.00

Map

 Project objective

Streptococcus suis is an endemic porcine disease causing causing significant economic losses to the pork meat production industry in all countries where pigs are reared on a large scale. In some countries S. suis is the primary cause of mortality and morbidity in young pigs and the most frequent reason to prescribe antibiotics of the amino-penicillin group as a preventative measure. S. suis is also a zoonotic pathogen of humans and infections reported worldwide has increased significantly in the past years. Within S. suis many different types (serotypes, genotypes, pathotypes) exist causing problems in the development of control strategies targeting all types. Asymptomatic carriage in adult pigs is common and combined with a lack of knowledge on the host-pathogen-environment interactions, are the main reasons for failure to control the endemic nature of this pathogen. The project outputs will impact on on understanding host-pathogen-environment interactions of S. suis infections through the genome sequencing of 1200-1500 S. suis isolates from representative geographic areas of the major pork producing countries and performing genome-wide-association studies with invasive disease and asymptomatic carriage. New diagnostic methods will be developed for global monitoring of infection risk and tested on case-farms. Epidemiology studies will determine risk factors for invasive S. suis disease, including the role of co-infections, and for the first time properly assess the dynamics of the disease on a representative farm. We will increase our understanding of the virulence mechanisms involved in pathogenesis including interactions of S. suis with the innate immune system. The project outputs will strengthen the evidence base for prevention and control strategies through testing of novel conserved vaccine antigens in pigs and prevention strategies based on manipulation of the microbiota and stimulation and maturation of the innate immune system.

 Deliverables

List of deliverables.
Mutants constructed in selected candidate virulence genes in S. suis strains Other 2020-03-06 18:15:24
Identification of genes required for fitness under in vivo mimicking conditions by Tn-Seq Documents, reports 2020-03-06 18:15:24
Report on the deep analysis of the microbiota composition in healthy and S. suis-diseased piglets Documents, reports 2020-03-06 18:15:24
Report on the ‘cornerstone’ species that are predicted to stabilize microbial communities in healthy piglets Documents, reports 2020-03-06 18:15:24
Sequencing of isolate collection Other 2020-03-06 18:15:24
Public Science Event 2 Websites, patent fillings, videos etc. 2020-03-06 18:15:24
Genome database containing core genome, meta data, virulence, serotype, MLST, antibiotic resistance Other 2020-03-06 18:15:24
Public Science Event 1 Websites, patent fillings, videos etc. 2020-03-06 18:15:24
Collection of isolates Other 2020-03-06 18:15:24
RReport on S. suis gene expression in blood/CSF vs artificial culture media Documents, reports 2020-03-06 18:15:24
Establishment of Project website and information share point Websites, patent fillings, videos etc. 2020-03-06 18:15:23
Report on effects of PRRSV infection on S. suis interaction in lung slices Documents, reports 2020-03-06 18:15:24

Take a look to the deliverables list in detail:  detailed list of PIGSs deliverables.

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