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Secret Surface SIGNED

The cell surface tetraspanin web drives tumour development and alters metabolic signalling

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 Secret Surface project word cloud

Explore the words cloud of the Secret Surface project. It provides you a very rough idea of what is the project "Secret Surface" about.

web    deficiency    tumour    physiological    interactions    multispectral    membrane    decipher    mosaic    cancer    lymphomas    endogenous    membranes    composition    complete    horizons    outcome    throughput    discovery    multiprotein    organization    tissue    hypothesize    imaging    cell    akt    microarray    resolve    clinically    spontaneous    function    uncontrolled    native    resolved    cells    signalling    functions    proteins    architecture    surface    cas9    survival    contain    preliminary    disrupted    cd37    select    data    unravel    evolutionary    clinical    contains    lymphomagenesis    cellular    patho    knock    mechanisms    activation    crispr    modified    secret    underlying    tetraspanins    tspan    conserved    therapies    outs    surrounded    physiology    molecular    reprogramming    proliferation    super    indicates    leads    proximal    complexes    toolbox    resolution    multiple    tetraspanin    tspans    aberrant    drives    coupled    microscopy    fluid    lymphoma    multidisciplinary    metabolic    generation   

Project "Secret Surface" data sheet

The following table provides information about the project.

Coordinator
STICHTING KATHOLIEKE UNIVERSITEIT 

Organization address
address: GEERT GROOTEPLEIN NOORD 9
city: NIJMEGEN
postcode: 6525 EZ
website: www.radboudumc.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 2˙000˙000 €
 EC max contribution 2˙000˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-COG
 Funding Scheme ERC-COG
 Starting year 2017
 Duration (year-month-day) from 2017-10-01   to  2022-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    STICHTING KATHOLIEKE UNIVERSITEIT NL (NIJMEGEN) coordinator 2˙000˙000.00

Map

 Project objective

Cancer development is characterized by uncontrolled proliferation, cell survival and metabolic reprogramming. Tumour cells are surrounded by a fluid-mosaic membrane that contains tetraspanins (Tspans) which are evolutionary conserved proteins important in the formation of multiprotein complexes at the cell surface (‘tetraspanin web’). Increasing evidence indicates that Tspans are involved in cancer, still the architecture of the Tspan web in native tumour membranes and its (patho)physiological functions have not been resolved. Based on my preliminary data, I hypothesize that tumour cells contain a disrupted Tspan web in which Tspan interactions are modified leading to aberrant metabolic signalling and tumour development. This is supported by my discovery that loss of Tspan CD37 leads to spontaneous lymphomagenesis due to activation of the Akt survival pathway. The overall aim of Secret Surface is to unravel the composition, physiological functions and molecular mechanisms of the Tspan web on tumour development and clinical outcome. To achieve this, I will focus on studying lymphomas using a multidisciplinary approach: I. Detailed analyses of Tspan web composition in lymphoma to select clinically relevant Tspans (high-throughput tissue microarray technology, multispectral imaging). II. Resolve the endogenous Tspan web on lymphoma cells (super-resolution microscopy), and generation and analysis of lymphoma cells that have a complete deficiency of multiple Tspans (CRISPR/Cas9 technology). III. Decipher molecular mechanisms underlying Tspan web function in lymphoma cells (membrane organization, membrane-proximal signalling, metabolic reprogramming). With my unique toolbox of Tspan knock-outs coupled to advanced microscopy and metabolic studies, I expect that Secret Surface will lead to a new concept in cellular physiology in which cell surface organization by the Tspan web drives tumour development, which may open new horizons for the generation of new cancer therapies.

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The information about "SECRET SURFACE" are provided by the European Opendata Portal: CORDIS opendata.

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