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Secret Surface SIGNED

The cell surface tetraspanin web drives tumour development and alters metabolic signalling

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 Secret Surface project word cloud

Explore the words cloud of the Secret Surface project. It provides you a very rough idea of what is the project "Secret Surface" about.

toolbox    crispr    spontaneous    interactions    tspans    clinically    lymphoma    underlying    uncontrolled    resolve    aberrant    tetraspanins    data    clinical    cd37    proximal    decipher    multiprotein    composition    deficiency    indicates    lymphomagenesis    survival    physiology    tissue    discovery    endogenous    microscopy    conserved    functions    imaging    resolution    cellular    proteins    patho    evolutionary    proliferation    throughput    function    outs    mechanisms    unravel    signalling    complexes    leads    architecture    fluid    tspan    tetraspanin    multispectral    drives    microarray    surface    complete    mosaic    outcome    metabolic    modified    contain    lymphomas    surrounded    membrane    super    resolved    preliminary    native    contains    cas9    reprogramming    multiple    coupled    organization    membranes    select    secret    cells    generation    horizons    molecular    cancer    tumour    multidisciplinary    activation    disrupted    hypothesize    akt    knock    web    physiological    cell    therapies   

Project "Secret Surface" data sheet

The following table provides information about the project.

Coordinator
STICHTING KATHOLIEKE UNIVERSITEIT 

Organization address
address: GEERT GROOTEPLEIN NOORD 9
city: NIJMEGEN
postcode: 6525 EZ
website: www.radboudumc.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 2˙000˙000 €
 EC max contribution 2˙000˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-COG
 Funding Scheme ERC-COG
 Starting year 2017
 Duration (year-month-day) from 2017-10-01   to  2022-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    STICHTING KATHOLIEKE UNIVERSITEIT NL (NIJMEGEN) coordinator 2˙000˙000.00

Map

 Project objective

Cancer development is characterized by uncontrolled proliferation, cell survival and metabolic reprogramming. Tumour cells are surrounded by a fluid-mosaic membrane that contains tetraspanins (Tspans) which are evolutionary conserved proteins important in the formation of multiprotein complexes at the cell surface (‘tetraspanin web’). Increasing evidence indicates that Tspans are involved in cancer, still the architecture of the Tspan web in native tumour membranes and its (patho)physiological functions have not been resolved. Based on my preliminary data, I hypothesize that tumour cells contain a disrupted Tspan web in which Tspan interactions are modified leading to aberrant metabolic signalling and tumour development. This is supported by my discovery that loss of Tspan CD37 leads to spontaneous lymphomagenesis due to activation of the Akt survival pathway. The overall aim of Secret Surface is to unravel the composition, physiological functions and molecular mechanisms of the Tspan web on tumour development and clinical outcome. To achieve this, I will focus on studying lymphomas using a multidisciplinary approach: I. Detailed analyses of Tspan web composition in lymphoma to select clinically relevant Tspans (high-throughput tissue microarray technology, multispectral imaging). II. Resolve the endogenous Tspan web on lymphoma cells (super-resolution microscopy), and generation and analysis of lymphoma cells that have a complete deficiency of multiple Tspans (CRISPR/Cas9 technology). III. Decipher molecular mechanisms underlying Tspan web function in lymphoma cells (membrane organization, membrane-proximal signalling, metabolic reprogramming). With my unique toolbox of Tspan knock-outs coupled to advanced microscopy and metabolic studies, I expect that Secret Surface will lead to a new concept in cellular physiology in which cell surface organization by the Tspan web drives tumour development, which may open new horizons for the generation of new cancer therapies.

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The information about "SECRET SURFACE" are provided by the European Opendata Portal: CORDIS opendata.

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