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Secret Surface SIGNED

The cell surface tetraspanin web drives tumour development and alters metabolic signalling

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 Secret Surface project word cloud

Explore the words cloud of the Secret Surface project. It provides you a very rough idea of what is the project "Secret Surface" about.

multiprotein    generation    proteins    organization    resolve    proximal    interactions    deficiency    data    secret    multiple    function    super    physiological    surrounded    evolutionary    patho    tspan    lymphoma    membranes    crispr    aberrant    discovery    cas9    outs    complete    conserved    underlying    surface    tumour    multispectral    outcome    mosaic    knock    cancer    functions    metabolic    hypothesize    multidisciplinary    cells    reprogramming    decipher    resolution    modified    leads    tissue    spontaneous    native    complexes    therapies    resolved    membrane    throughput    imaging    microscopy    lymphomagenesis    fluid    activation    toolbox    disrupted    tetraspanin    survival    cell    tetraspanins    mechanisms    select    clinical    clinically    tspans    microarray    proliferation    drives    indicates    akt    uncontrolled    molecular    contain    cellular    physiology    preliminary    unravel    lymphomas    endogenous    coupled    signalling    horizons    cd37    web    composition    architecture    contains   

Project "Secret Surface" data sheet

The following table provides information about the project.

Coordinator
STICHTING KATHOLIEKE UNIVERSITEIT 

Organization address
address: GEERT GROOTEPLEIN NOORD 9
city: NIJMEGEN
postcode: 6525 EZ
website: www.radboudumc.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 2˙000˙000 €
 EC max contribution 2˙000˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-COG
 Funding Scheme ERC-COG
 Starting year 2017
 Duration (year-month-day) from 2017-10-01   to  2022-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    STICHTING KATHOLIEKE UNIVERSITEIT NL (NIJMEGEN) coordinator 2˙000˙000.00

Map

 Project objective

Cancer development is characterized by uncontrolled proliferation, cell survival and metabolic reprogramming. Tumour cells are surrounded by a fluid-mosaic membrane that contains tetraspanins (Tspans) which are evolutionary conserved proteins important in the formation of multiprotein complexes at the cell surface (‘tetraspanin web’). Increasing evidence indicates that Tspans are involved in cancer, still the architecture of the Tspan web in native tumour membranes and its (patho)physiological functions have not been resolved. Based on my preliminary data, I hypothesize that tumour cells contain a disrupted Tspan web in which Tspan interactions are modified leading to aberrant metabolic signalling and tumour development. This is supported by my discovery that loss of Tspan CD37 leads to spontaneous lymphomagenesis due to activation of the Akt survival pathway. The overall aim of Secret Surface is to unravel the composition, physiological functions and molecular mechanisms of the Tspan web on tumour development and clinical outcome. To achieve this, I will focus on studying lymphomas using a multidisciplinary approach: I. Detailed analyses of Tspan web composition in lymphoma to select clinically relevant Tspans (high-throughput tissue microarray technology, multispectral imaging). II. Resolve the endogenous Tspan web on lymphoma cells (super-resolution microscopy), and generation and analysis of lymphoma cells that have a complete deficiency of multiple Tspans (CRISPR/Cas9 technology). III. Decipher molecular mechanisms underlying Tspan web function in lymphoma cells (membrane organization, membrane-proximal signalling, metabolic reprogramming). With my unique toolbox of Tspan knock-outs coupled to advanced microscopy and metabolic studies, I expect that Secret Surface will lead to a new concept in cellular physiology in which cell surface organization by the Tspan web drives tumour development, which may open new horizons for the generation of new cancer therapies.

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The information about "SECRET SURFACE" are provided by the European Opendata Portal: CORDIS opendata.

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