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Secret Surface SIGNED

The cell surface tetraspanin web drives tumour development and alters metabolic signalling

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 Secret Surface project word cloud

Explore the words cloud of the Secret Surface project. It provides you a very rough idea of what is the project "Secret Surface" about.

super    mosaic    microscopy    membranes    tetraspanins    metabolic    indicates    surrounded    proteins    multiprotein    resolve    multispectral    multidisciplinary    web    resolution    proximal    tissue    complexes    uncontrolled    surface    patho    molecular    cancer    outs    underlying    hypothesize    leads    cellular    cell    reprogramming    resolved    mechanisms    disrupted    imaging    tspans    contain    function    tumour    preliminary    tetraspanin    fluid    microarray    throughput    physiology    lymphomagenesis    crispr    unravel    functions    lymphoma    cas9    tspan    coupled    aberrant    membrane    therapies    complete    activation    decipher    secret    architecture    cells    select    physiological    clinically    drives    deficiency    evolutionary    akt    endogenous    spontaneous    proliferation    native    cd37    signalling    composition    organization    horizons    toolbox    data    conserved    multiple    contains    knock    discovery    lymphomas    clinical    outcome    generation    modified    interactions    survival   

Project "Secret Surface" data sheet

The following table provides information about the project.

Coordinator
STICHTING KATHOLIEKE UNIVERSITEIT 

Organization address
address: GEERT GROOTEPLEIN NOORD 9
city: NIJMEGEN
postcode: 6525 EZ
website: www.radboudumc.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 2˙000˙000 €
 EC max contribution 2˙000˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-COG
 Funding Scheme ERC-COG
 Starting year 2017
 Duration (year-month-day) from 2017-10-01   to  2022-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    STICHTING KATHOLIEKE UNIVERSITEIT NL (NIJMEGEN) coordinator 2˙000˙000.00

Map

 Project objective

Cancer development is characterized by uncontrolled proliferation, cell survival and metabolic reprogramming. Tumour cells are surrounded by a fluid-mosaic membrane that contains tetraspanins (Tspans) which are evolutionary conserved proteins important in the formation of multiprotein complexes at the cell surface (‘tetraspanin web’). Increasing evidence indicates that Tspans are involved in cancer, still the architecture of the Tspan web in native tumour membranes and its (patho)physiological functions have not been resolved. Based on my preliminary data, I hypothesize that tumour cells contain a disrupted Tspan web in which Tspan interactions are modified leading to aberrant metabolic signalling and tumour development. This is supported by my discovery that loss of Tspan CD37 leads to spontaneous lymphomagenesis due to activation of the Akt survival pathway. The overall aim of Secret Surface is to unravel the composition, physiological functions and molecular mechanisms of the Tspan web on tumour development and clinical outcome. To achieve this, I will focus on studying lymphomas using a multidisciplinary approach: I. Detailed analyses of Tspan web composition in lymphoma to select clinically relevant Tspans (high-throughput tissue microarray technology, multispectral imaging). II. Resolve the endogenous Tspan web on lymphoma cells (super-resolution microscopy), and generation and analysis of lymphoma cells that have a complete deficiency of multiple Tspans (CRISPR/Cas9 technology). III. Decipher molecular mechanisms underlying Tspan web function in lymphoma cells (membrane organization, membrane-proximal signalling, metabolic reprogramming). With my unique toolbox of Tspan knock-outs coupled to advanced microscopy and metabolic studies, I expect that Secret Surface will lead to a new concept in cellular physiology in which cell surface organization by the Tspan web drives tumour development, which may open new horizons for the generation of new cancer therapies.

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The information about "SECRET SURFACE" are provided by the European Opendata Portal: CORDIS opendata.

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