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MCircuits SIGNED

Connectivity, plasticity and function of an olfactory memory circuit

Total Cost €

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EC-Contrib. €

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Partnership

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 MCircuits project word cloud

Explore the words cloud of the MCircuits project. It provides you a very rough idea of what is the project "MCircuits" about.

responding    plasticity    inputs    disease    analyzing    patterns    scanning    memory    uncover    electrophysiology    dissect    imaging    mechanistic    small    advantages    memories    zebrafish    circuit    accumulates    links    sbem    telencephalic    metaplasticity    dynamics    size    activation    elementary    difficult    combined    mutations    wiring    tests    intelligent    thought    adult    reconstructions    brains    odors    block    provides    dp    representations    creates    diagrams    discrimination    microscopy    write    functions    models    examined    neuronal    guided    underlying    reconstruction    world    serial    fundamental    brain    virtual    behavior    cortex    homologue    structure    odor    stability    structural    environment    causal    electron    synaptic    cellular    theoretical    connectivity    learning    optogenetic    disrupt    mutants    ensembles    relationships    learned    stimulation    neuromodulatory    functional    mechanisms    direct    exhaustive    analyze    function    dense    modifications    computations    insights    generate    silencing    autoassociative    olfactory    area    predictions   

Project "MCircuits" data sheet

The following table provides information about the project.

Coordinator
FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION 

Organization address
address: MAULBEERSTRASSE 66
city: BASEL
postcode: 4058
website: www.fmi.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 2˙495˙838 €
 EC max contribution 2˙495˙838 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-ADG
 Funding Scheme ERC-ADG
 Starting year 2017
 Duration (year-month-day) from 2017-10-01   to  2022-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION CH (BASEL) coordinator 2˙495˙838.00

Map

 Project objective

The brain accumulates knowledge by experience-driven modifications of neuronal connectivity and creates models of the world that enable intelligent behavior. It is thought that these processes are based on autoassociative mechanisms of circuit plasticity. However, direct tests of these fundamental concepts are difficult because they require dense reconstructions of neuronal wiring diagrams. We will dissect structural and functional mechanisms of autoassociative memory in telencephalic area Dp of adult zebrafish, the homologue of olfactory cortex. The small size of the zebrafish brain provides essential advantages for exhaustive measurements of neuronal activity and connectivity patterns. Key predictions of theoretical models will be examined by analyzing effects of odor discrimination learning on the dynamics and stability of odor representations in Dp. The underlying structural circuit modifications will be examined in the same brains by circuit reconstruction using serial block face scanning electron microscopy (SBEM). The dense reconstruction of neuronal ensembles responding to learned and novel odors will allow for advanced analyses of structure-function relationships that have not been possible so far. Odor stimulation in a virtual environment will be combined with optogenetic activation or silencing of neuromodulatory inputs to write and disrupt specific olfactory memories and to analyze the effects on behavior and connectivity. The underlying cellular mechanisms of synaptic plasticity and metaplasticity will be examined by electrophysiology, imaging and optogenetic approaches. Mutants will be used to assess effects of disease-related mutations on circuit structure, function and plasticity. These mechanistic analyses are guided by theoretical models, expected to generate direct insights into elementary computations underlying higher brain functions, and likely to uncover causal links between circuit connectivity, circuit function and behavior.

 Publications

year authors and title journal last update
List of publications.
2018 Christel Genoud, Benjamin Titze, Alexandra Graff-Meyer, Rainer W. Friedrich
Fast Homogeneous En Bloc Staining of Large Tissue Samples for Volume Electron Microscopy
published pages: , ISSN: 1662-5129, DOI: 10.3389/fnana.2018.00076
Frontiers in Neuroanatomy 12 2019-06-06
2018 Peter Rupprecht, Rainer W. Friedrich
Precise Synaptic Balance in the Zebrafish Homolog of Olfactory Cortex
published pages: 669-683.e5, ISSN: 0896-6273, DOI: 10.1016/j.neuron.2018.09.013
Neuron 100/3 2019-06-07
2018 Iori Namekawa, Nila R. Moenig, Rainer W. Friedrich
Rapid olfactory discrimination learning in adult zebrafish
published pages: 2959-2969, ISSN: 0014-4819, DOI: 10.1007/s00221-018-5352-x
Experimental Brain Research 236/11 2019-06-06
2018 Benjamin Titze, Christel Genoud, Rainer W. Friedrich
SBEMimage: Versatile Acquisition Control Software for Serial Block-Face Electron Microscopy
published pages: , ISSN: 1662-5110, DOI: 10.3389/fncir.2018.00054
Frontiers in Neural Circuits 12 2019-06-06

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