Explore the words cloud of the PRIMATE-TE-IMPACT project. It provides you a very rough idea of what is the project "PRIMATE-TE-IMPACT" about.
The following table provides information about the project.
UNIVERSITEIT VAN AMSTERDAM
|Coordinator Country||Netherlands [NL]|
|Total cost||1˙500˙000 €|
|EC max contribution||1˙500˙000 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2017-08-01 to 2022-07-31|
Take a look of project's partnership.
|1||UNIVERSITEIT VAN AMSTERDAM||NL (AMSTERDAM)||coordinator||1˙500˙000.00|
Throughout evolution, the human genome has been attacked by retrotransposons, parasitic DNA elements that spread through our genome by a copy-paste activity. I previously showed that SVA elements, the youngest class of retrotransposons in our genome, harbour a strong gene-regulatory potential which is normally repressed by KRAB zinc finger protein ZNF91 (Jacobs et al., 2014, Nature). However, for reasons unknown, repression of retrotransposons is much less efficient in the human brain, resulting in activation of the enhancer potential of SVA elements spread throughout the human genome. The importance of these SVA insertions for the evolution of human neuronal gene-regulatory networks, and how many genes have come to depend on SVA's regulatory influence, remains elusive. In this research program, I will use ‘cortical organoids’; three-dimensional brain tissues derived from human and primate stem cells, to investigate how recent SVA insertions have impacted human neuronal gene expression. Furthermore, I will investigate how changes of the epigenetic landscape in neurons affect the activity of retrotransposons in our genome and the influence they have on nearby neuronal genes. Finally, I will explore the possibility that loss of epigenetic silencing of retrotransposons is responsible for dysregulation of genes associated with neurological diseases. Preliminary findings suggest a potential role for retrotransposons in susceptibility loci for Alzheimer's and Parkinson's disease. Finding further support for this in the current research program, will form the basis of a novel concept which explains how changes in the epigenetic landscape can uncover a dormant genetic predisposition to disease.
|year||authors and title||journal||last update|
Grace Farmiloe, Gerrald A. Lodewijk, Stijn F. Robben, Elisabeth J. van Bree, Frank M. J. Jacobs
Widespread correlation of KRAB zinc finger protein binding with brain-developmental gene expression patterns
published pages: 20190333, ISSN: 0962-8436, DOI: 10.1098/rstb.2019.0333
|Philosophical Transactions of the Royal Society B: Biological Sciences 375/1795||2020-04-03|
Nilda Vanesa Ayala-Nunez, Gautier Follain, FranÃ§ois Delalande, AurÃ©lie Hirschler, Emma Partiot, Gillian L. Hale, Brigid C. Bollweg, Judith Roels, Maxime Chazal, Florian Bakoa, Margot Carocci, Sandrine Bourdoulous, Orestis Faklaris, Sherif R. Zaki, Anita Eckly, BÃ©atrice Uring-Lambert, FrÃ©dÃ©ric Doussau, Sarah Cianferani, Christine Carapito, Frank M. J. Jacobs, Nolwenn Jouvenet, Jacky G. Goetz,
Zika virus enhances monocyte adhesion and transmigration favoring viral dissemination to neural cells
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-12408-x
|Nature Communications 10/1||2020-04-03|
Ian T. Fiddes, Gerrald A. Lodewijk, Meghan Mooring, Colleen M. Bosworth, Adam D. Ewing, Gary L. Mantalas, Adam M. Novak, Anouk van den Bout, Alex Bishara, Jimi L. Rosenkrantz, Ryan Lorig-Roach, Andrew R. Field, Maximilian Haeussler, Lotte Russo, Aparna Bhaduri, Tomasz J. Nowakowski, Alex A. Pollen, Max L. Dougherty, Xander Nuttle, Marie-Claude Addor, Simon Zwolinski, Sol Katzman, Arnold Kriegstein, Evan E. Eichler, Sofie R. Salama, Frank M.J. Jacobs, David Haussler
Human-Specific NOTCH2NL Genes Affect Notch Signaling and Cortical Neurogenesis
published pages: 1356-1369.e22, ISSN: 0092-8674, DOI: 10.1016/j.cell.2018.03.051
Diana Pereira Fernandes, MainÃ¡ Bitar, Frank Jacobs, Guy Barry
Long Non-Coding RNAs in Neuronal Aging
published pages: 12, ISSN: 2311-553X, DOI: 10.3390/ncrna4020012
|Non-Coding RNA 4/2||2019-04-16|
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