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TWINNING for a Comprehensive Clinical Centre for the Diagnosis and Treatment of Parkinson's Disease

Total Cost €


EC-Contrib. €






 CENTRE-PD project word cloud

Explore the words cloud of the CENTRE-PD project. It provides you a very rough idea of what is the project "CENTRE-PD" about.

unlike    scientists    centre    innovation    pd    luxembourg    strengthen    hampers    industry    stimulation    brain    involvement    public    clinical    translation    stem    adoption    stakeholders    biomedicine    fundamental    economic    infrastructures    joint    biomarker    uuml    diagnosis    basic    centres    stratification    human    neuro    twinning    institutional    validation    medicine    oxford    capacity    cohort    edge    models    university    science    substantial    bank    competitive    platforms    successful    patient    training    borders       building    realise    last    campaings    government    cellular    tradition    launching    position    benefits    cutting    risk    competence    closing    bingen    modulation    datasets    efforts    boosting    parkinson    lacks    ul    outreach    harmonised    gait    health    placed    neuropathological    treatment    population    excellence    biomedical    imaging    laboratory    collaborations    made    driver    viability    engaging    screening    external    cell    sustainability    compound    prospective    worldwide    internationally    excellent    gap    disease    universities    nationally   

Project "CENTRE-PD" data sheet

The following table provides information about the project.


Organization address
postcode: 4365

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Luxembourg [LU]
 Project website
 Total cost 1˙062˙500 €
 EC max contribution 1˙062˙500 € (100%)
 Programme 1. H2020-EU.4.b. (Twinning of research institutions)
 Code Call H2020-TWINN-2015
 Funding Scheme CSA
 Starting year 2016
 Duration (year-month-day) from 2016-03-01   to  2019-02-28


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Unlike other EU member states, Luxembourg lacks a tradition for translation of fundamental research into clinical practice, which hampers health innovation and its adoption in cutting-edge medicine. During the last years, the Luxembourg Government made substantial efforts to position biomedicine as a key innovation driver. This highly successful biomedical initiative placed fundamental research on Parkinson’s disease (PD) in Luxembourg on an internationally competitive level, however, to realise the economic and health benefits for the population, closing the gap between basic science and clinical application is now a crucial challenge. CENTRE-PD aims at TWINNING the Universities of Oxford and Tübingen, two worldwide leading centres for PD, with the University of Luxembourg (UL) to establish a comprehensive clinical PD centre in Luxembourg. CENTRE-PD will build human and institutional capacity for an excellent centre for diagnosis and treatment of PD in Luxembourg on the one hand and will ensure sustainability and viability of the centre on the other hand. We expect to reach key deliverables in three areas: (i) building of new infrastructures at UL (including a prospective PD patient cohort and at-risk cohort, a brain bank, neuro-imaging and stem-cell platforms, a neuro-stimulation centre and gait laboratory), (ii) launching of joint research initiatives (harmonised clinical datasets and neuropathological validation, joint biomarker studies for early diagnosis and stratification of PD, compound screening campaings on patient-based cellular models, and joint studies on neuro-modulation), and (iii) engaging key stakeholders through clinical and public outreach programmes, training of clinical researchers and basic scientists, partnerships with industry and initiatives for patient involvement. The external excellent competence provided through TWINNING will strengthen the potential for future collaborations nationally and beyond borders, boosting research excellence.


List of deliverables.
Implementation of a gait laboratory using telemetric assessments in Luxembourg Documents, reports 2019-09-13 11:09:58
Definition of criteria for the recruitment of an at-risk-cohort in Luxembourg Documents, reports 2019-09-13 11:09:58
Standardised protocols for iPSC-based models (reprogramming, maintenance, gene editing) Documents, reports 2019-09-13 11:09:58
Working paper for management of the comprehensive clinical PD centre Documents, reports 2019-09-13 11:09:58
Research and Industrial collaborations established Documents, reports 2019-09-13 11:09:59
Common neuro-imaging platform multivariate feature discovery in PD Documents, reports 2019-09-13 11:09:58
Evaluation procedures Documents, reports 2019-09-13 11:09:58
Website/Intranet Websites, patent fillings, videos etc. 2019-09-13 11:09:57
Movement disorders curriculum Documents, reports 2019-09-13 11:09:57
Ethical approval for brain banking in Luxembourg Documents, reports 2019-09-13 11:09:57
Comprehensive awareness programme plan Documents, reports 2019-09-13 11:09:57

Take a look to the deliverables list in detail:  detailed list of CENTRE-PD deliverables.


year authors and title journal last update
List of publications.
2018 Geraldine Hipp, Michel Vaillant, Nico J. Diederich, Kirsten Roomp, Venkata P. Satagopam, Peter Banda, Estelle Sandt, Kathleen Mommaerts, Sabine K. Schmitz, Laura Longhino, Alexandra Schweicher, Anne-Marie Hanff, Béatrice Nicolai, Pierre Kolber, Dorothea Reiter, Lukas Pavelka, Sylvia Binck, Claire Pauly, Lars Geffers, Fay Betsou, Manon Gantenbein, Jochen Klucken, Thomas Gasser, Michele T. Hu, Rudi Balling, Rejko Krüger
The Luxembourg Parkinson’s Study: A Comprehensive Approach for Stratification and Early Diagnosis
published pages: , ISSN: 1663-4365, DOI: 10.3389/fnagi.2018.00326
Frontiers in Aging Neuroscience 10 2019-09-13
2018 S. B. Larsen, Z. Hanss, R. Krüger
The genetic architecture of mitochondrial dysfunction in Parkinson’s disease
published pages: 21-37, ISSN: 0302-766X, DOI: 10.1007/s00441-017-2768-8
Cell and Tissue Research 373/1 2019-09-13
2018 Jochen Klucken, Rejko Krüger, Peter Schmidt, Bastiaan R. Bloem
Management of Parkinson’s Disease 20 Years from Now: Towards Digital Health Pathways
published pages: S85-S94, ISSN: 1877-7171, DOI: 10.3233/jpd-181519
Journal of Parkinson\'s Disease 8/s1 2019-09-13
2017 Rejko Krüger, Paul Lingor, Triantafyllos Doskas, Johanna M. L. Henselmans, Erik H. Danielsen, Oriol de Fabregues, Alessandro Stefani, Sven-Christian Sensken, Juan Carlos Parra, Koray Onuk, Ashley Yegin, Angelo Antonini
An Observational Study of the Effect of Levodopa–Carbidopa Intestinal Gel on Activities of Daily Living and Quality of Life in Advanced Parkinson’s Disease Patients
published pages: 1741-1752, ISSN: 0741-238X, DOI: 10.1007/s12325-017-0571-2
Advances in Therapy 34/7 2019-09-13
2017 Cornelis Blauwendraat, Faraz Faghri, Lasse Pihlstrom, Joshua T. Geiger, Alexis Elbaz, Suzanne Lesage, Jean-Christophe Corvol, Patrick May, Aude Nicolas, Yevgeniya Abramzon, Natalie A. Murphy, J. Raphael Gibbs, Mina Ryten, Raffaele Ferrari, Jose Bras, Rita Guerreiro, Julie Williams, Rebecca Sims, Steven Lubbe, Dena G. Hernandez, Kin Y. Mok, Laurie Robak, Roy H. Campbell, Ekaterina Rogaeva, Bryan J. Traynor, Ruth Chia, Sun Ju Chung, John A. Hardy, Alexis Brice, Nicholas W. Wood, Henry Houlden, Joshua M. Shulman, Huw R. Morris, Thomas Gasser, Rejko Krüger, Peter Heutink, Manu Sharma, Javier Simón-Sánchez, Mike A. Nalls, Andrew B. Singleton, Sonja W. Scholz
NeuroChip, an updated version of the NeuroX genotyping platform to rapidly screen for variants associated with neurological diseases
published pages: 247.e9-247.e13, ISSN: 0197-4580, DOI: 10.1016/j.neurobiolaging.2017.05.009
Neurobiology of Aging 57 2019-09-13
2016 W. Maetzler, R. Krüger, T. Müller, W. Oertel, P. Urban, T. Warnecke, J. Klucken
Tragbare und aktiv vom Parkinson-Patienten genutzte Technologie im häuslichen Umfeld: Was bringt die Zukunft?
published pages: S48-S51, ISSN: 0720-4299, DOI: 10.1055/s-0042-102786
Fortschritte der Neurologie · Psychiatrie 84/S 01 2019-09-13
2016 Daniel Weiss, Sonja Herrmann, Lisa Wang, Claudia Schulte, Kathrin Brockmann, Christian Plewnia, Thomas Gasser, Manu Sharma, Alireza Gharabaghi, Rejko Krüger
Alpha-synuclein gene variants may predict neurostimulation outcome
published pages: 601-603, ISSN: 0885-3185, DOI: 10.1002/mds.26558
Movement Disorders 31/4 2019-09-13
2017 Julia C Fitzgerald, Alexander Zimprich, Daniel A Carvajal Berrio, Kevin M Schindler, Brigitte Maurer, Claudia Schulte, Christine Bus, Anne-Kathrin Hauser, Manuela Kübler, Rahel Lewin, Dheeraj Reddy Bobbili, Lisa M Schwarz, Evangelia Vartholomaiou, Kathrin Brockmann, Richard Wüst, Johannes Madlung, Alfred Nordheim, Olaf Riess, L Miguel Martins, Enrico Glaab, Patrick May, Katja Schenke-Layland, Didier Picard, Manu Sharma, Thomas Gasser, Rejko Krüger
Metformin reverses TRAP1 mutation-associated alterations in mitochondrial function in Parkinson’s disease
published pages: 2444-2459, ISSN: 0006-8950, DOI: 10.1093/brain/awx202
Brain 140/9 2019-09-13
2016 Richard Wüst, Brigitte Maurer, Kathrin Hauser, Dirk Woitalla, Manu Sharma, Rejko Krüger
Mutation analyses and association studies to assess the role of the presenilin-associated rhomboid-like gene in Parkinson\'s disease
published pages: 217.e13-217.e15, ISSN: 0197-4580, DOI: 10.1016/j.neurobiolaging.2015.11.025
Neurobiology of Aging 39 2019-09-13
2016 Michael Lawton, Meike Kasten, Margaret T. May, Brit Mollenhauer, Martina Schaumburg, Inga Liepelt-Scarfone, Walter Maetzler, Eva-Juliane Vollstedt, Michele T.M. Hu, Daniela Berg, Yoav Ben-Shlomo
Validation of conversion between mini-mental state examination and montreal cognitive assessment
published pages: 593-596, ISSN: 0885-3185, DOI: 10.1002/mds.26498
Movement Disorders 31/4 2019-09-13
2016 Marlieke Scholten, Rathinaswamy B. Govindan, Christoph Braun, Bastiaan R. Bloem, Christian Plewnia, Rejko Krüger, Alireza Gharabaghi, Daniel Weiss
Cortical correlates of susceptibility to upper limb freezing in Parkinson’s disease
published pages: 2386-2393, ISSN: 1388-2457, DOI: 10.1016/j.clinph.2016.01.028
Clinical Neurophysiology 127/6 2019-09-13
2017 Lisa Wang, Michael G. Heckman, Jan O. Aasly, Grazia Annesi, Maria Bozi, Sun Ju Chung, Carl Clarke, David Crosiers, Gertrud Eckstein, Gaetan Garraux, Georgios M. Hadjigeorgiou, Nobu Hattori, Beom Jeon, Yun J. Kim, Masato Kubo, Suzanne Lesage, Juei Jueng Lin, Timothy Lynch, Peter Lichtner, George D. Mellick, Vincent Mok, Karin E. Morrison, Aldo Quattrone, Wataru Satake, Peter A. Silburn, Leonidas Stefanis, Joanne D. Stockton, Eng King Tan, Tatsushi Toda, Alexis Brice, Christine Van Broeckhoven, Ryan J. Uitti, Karin Wirdefeldt, Zbigniew Wszolek, Georgia Xiromerisiou, Demetrius M. Maraganore, Thomas Gasser, Rejko Krüger, Matthew J. Farrer, Owen A. Ross, Manu Sharma
Evaluation of the interaction between LRRK2 and PARK16 loci in determining risk of Parkinson\'s disease: analysis of a large multicenter study
published pages: 217.e1-217.e4, ISSN: 0197-4580, DOI: 10.1016/j.neurobiolaging.2016.09.022
Neurobiology of Aging 49 2019-09-13
2017 Rejko Krüger, Jochen Klucken, Daniel Weiss, Lars Tönges, Pierre Kolber, Stefan Unterecker, Michael Lorrain, Horst Baas, Thomas Müller, Peter Riederer
Classification of advanced stages of Parkinson’s disease: translation into stratified treatments
published pages: 1015-1027, ISSN: 0300-9564, DOI: 10.1007/s00702-017-1707-x
Journal of Neural Transmission 124/8 2019-09-13
2016 Stefanie Lerche, Sebastian Heinzel, Guido W. Alves, Paolo Barone, Stefanie Behnke, Yoav Ben-Shlomo, Henk Berendse, Bastiaan R. Bloem, David Burn, Richard Dodel, Donald G. Grosset, Geraldine Hipp, Michele T. Hu, Meike Kasten, Rejko Krüger, Inga Liepelt-Scarfone, Walter Maetzler, Marcello Moccia, Brit Mollenhauer, Wolfgang Oertel, Benjamin Roeben, Uwe Walter, Karin Wirdefeldt, Daniela Berg
Aiming for Study Comparability in Parkinson\'s Disease: Proposal for a Modular Set of Biomarker Assessments to be Used in Longitudinal Studies
published pages: , ISSN: 1663-4365, DOI: 10.3389/fnagi.2016.00121
Frontiers in Aging Neuroscience 8 2019-09-13
2016 Nicolas Casadei, Poonam Sood, Thomas Ulrich, Petra Fallier-Becker, Nicole Kieper, Stefan Helling, Caroline May, Enrico Glaab, Jing Chen, Silke Nuber, Katrin Marcus, Doron Rapaport, Thomas Ott, Olaf Riess, Rejko Krüger, Julia C. Fitzgerald
Mitochondrial defects and neurodegeneration in mice overexpressing wild-type or G399S mutant HtrA2
published pages: 459-471, ISSN: 0964-6906, DOI: 10.1093/hmg/ddv485
Human Molecular Genetics 25/3 2019-09-13
2016 Sebastian Heinzel, Benjamin Roeben, Yoav Ben-Shlomo, Stefanie Lerche, Guido Alves, Paolo Barone, Stefanie Behnke, Henk W. Berendse, Bastiaan R. Bloem, David Burn, Richard Dodel, Donald G. Grosset, Michele Hu, Meike Kasten, Rejko Krüger, Marcello Moccia, Brit Mollenhauer, Wolfgang Oertel, Ulrike Suenkel, Uwe Walter, Karin Wirdefeldt, Inga Liepelt-Scarfone, Walter Maetzler, Daniela Berg
Prodromal Markers in Parkinson’s Disease: Limitations in Longitudinal Studies and Lessons Learned
published pages: , ISSN: 1663-4365, DOI: 10.3389/fnagi.2016.00147
Frontiers in Aging Neuroscience 8 2019-09-13

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