Opendata, web and dolomites

Epilepsy_Core SIGNED

The core and effects of epilepsy: from chronic disease to curable disorder through innovative guided surgery

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 Epilepsy_Core project word cloud

Explore the words cloud of the Epilepsy_Core project. It provides you a very rough idea of what is the project "Epilepsy_Core" about.

levels    direct    effect    pivotal    prerequisites    surgeries    coupling    solutions    oscillations    susceptible    standards    evoke    adhesive    stochastic    diverse    uniform    cognitive    brain    postsurgical    neurosurgical    stop    tissue    machine    integrate    reflection    obtain    techniques    gliomas    signal    frequency    seizures    simplifies    people    hfos    seizure    otherwise    distorted    cure    density    cross    epileptic    surgery    outcomes    disorders    broad    markers    microlevel    burdens    pinpointing    epilepsy    electrical    200    innovate    learning    limited    epileptogenic    electrodes       distance    core    radically    epileptogenicity    initiated    recordings    recording    versus    time    healthy    macrolevel    data    diseased    distorting    pilot    population    epiphenomena    projecting    meningiomas    regression    epitome    partly    operative    uncover    appear    stimulation    connectivity    generation    discovered    auto    decline    device    sudden    unsuccessful    noise    invasive    tumors    supervised    unguided    gold    normal    physiological    eeg    functioning    disease    optimize    compress    removing    cortex    impairment    functional    hfo    focal    electrocorticography    spreading    explore    guidance    performance   

Project "Epilepsy_Core" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAIR MEDISCH CENTRUM UTRECHT 

Organization address
address: HEIDELBERGLAAN 100
city: UTRECHT
postcode: 3584 CX
website: www.umcutrecht.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-03-01   to  2024-02-29

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAIR MEDISCH CENTRUM UTRECHT NL (UTRECHT) coordinator 1˙500˙000.00

Map

 Project objective

Epilepsy burdens 1% of the population. Brain surgery can cure seizures and stop cognitive decline, but it is complex and often unsuccessful. I aim to advance cure from epileptic brain disease radically by 1) pinpointing the core of epilepsy and 2) understanding the effects on normal brain functioning.

High-frequency oscillations (HFOs) are novel markers of the core of focal epilepsy, discovered in long-term invasive EEG. I initiated direct HFO-based guidance of epilepsy surgery with intra-operative invasive electrodes. However, HFOs still appear stochastic epiphenomena. Therefore, I will now uncover the direct microlevel high-frequency EEG reflection of the distorted cortex. I will use three macrolevel signal prerequisites for seizure and HFO generation to innovate intra-operative recording and signal analysis: susceptible (evoke with long-distance electrical stimulation; cross-frequency coupling), sudden (low-noise adhesive electrodes; auto-regression) & spreading (high-density recordings; functional connectivity). I will pilot test technical solutions and optimize analyses with supervised machine learning based on pivotal epileptogenic versus healthy tissue and on postsurgical outcomes. Next, I will explore the broad effect of epileptic on physiological high frequency brain activity taking cognitive performance as epitome, especially in people without seizures.

Current electrocorticography data come from limited, diverse and complex cases with no gold standards for diseased and normal cortex. I will therefore obtain data from 200 otherwise unguided brain surgeries with different levels of epileptogenicity and cognitive impairment: highly epileptogenic tumors (simple), gliomas (many) and meningiomas which compress healthy brain (uniform; partly without seizures).

I will integrate techniques in a neurosurgical real-time recording and projecting device that simplifies finding and removing epileptogenic tissue to stop the distorting effect in focal brain disorders.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "EPILEPSY_CORE" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "EPILEPSY_CORE" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

evolSingleCellGRN (2019)

Constraint, Adaptation, and Heterogeneity: Genomic and single-cell approaches to understanding the evolution of developmental gene regulatory networks

Read More  

HEIST (2020)

High-temperature Electrochemical Impedance Spectroscopy Transmission electron microscopy on energy materials

Read More  

IMMUNOTHROMBOSIS (2019)

Cross-talk between platelets and immunity - implications for host homeostasis and defense

Read More