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Epilepsy_Core SIGNED

The core and effects of epilepsy: from chronic disease to curable disorder through innovative guided surgery

Total Cost €

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EC-Contrib. €

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Partnership

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 Epilepsy_Core project word cloud

Explore the words cloud of the Epilepsy_Core project. It provides you a very rough idea of what is the project "Epilepsy_Core" about.

electrodes    operative    levels    distorting    cross    susceptible    solutions    distorted    stimulation    guidance    pilot    device    limited    population    time    radically    appear    density    burdens    hfo    impairment    frequency    tumors    partly    connectivity    compress    cognitive    pivotal    functioning    initiated    techniques    healthy    electrical    adhesive    epileptogenic    explore    obtain    data    generation    recordings    coupling    functional    surgeries    effect    unsuccessful    eeg    brain    oscillations    projecting    focal    normal    uniform    postsurgical    epitome    meningiomas    innovate    regression    performance    stop    markers    prerequisites    unguided    invasive    learning    otherwise    evoke    epilepsy    core    optimize    sudden    epileptogenicity    neurosurgical    integrate    outcomes    epiphenomena    people    broad    spreading    seizures       simplifies    200    machine    reflection    standards    cortex    gliomas    physiological    decline    disease    auto    seizure    microlevel    epileptic    versus    gold    discovered    cure    distance    hfos    stochastic    disorders    surgery    diverse    removing    signal    macrolevel    supervised    diseased    tissue    noise    pinpointing    electrocorticography    recording    uncover    direct   

Project "Epilepsy_Core" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAIR MEDISCH CENTRUM UTRECHT 

Organization address
address: HEIDELBERGLAAN 100
city: UTRECHT
postcode: 3584 CX
website: www.umcutrecht.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-03-01   to  2024-02-29

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAIR MEDISCH CENTRUM UTRECHT NL (UTRECHT) coordinator 1˙500˙000.00

Map

 Project objective

Epilepsy burdens 1% of the population. Brain surgery can cure seizures and stop cognitive decline, but it is complex and often unsuccessful. I aim to advance cure from epileptic brain disease radically by 1) pinpointing the core of epilepsy and 2) understanding the effects on normal brain functioning.

High-frequency oscillations (HFOs) are novel markers of the core of focal epilepsy, discovered in long-term invasive EEG. I initiated direct HFO-based guidance of epilepsy surgery with intra-operative invasive electrodes. However, HFOs still appear stochastic epiphenomena. Therefore, I will now uncover the direct microlevel high-frequency EEG reflection of the distorted cortex. I will use three macrolevel signal prerequisites for seizure and HFO generation to innovate intra-operative recording and signal analysis: susceptible (evoke with long-distance electrical stimulation; cross-frequency coupling), sudden (low-noise adhesive electrodes; auto-regression) & spreading (high-density recordings; functional connectivity). I will pilot test technical solutions and optimize analyses with supervised machine learning based on pivotal epileptogenic versus healthy tissue and on postsurgical outcomes. Next, I will explore the broad effect of epileptic on physiological high frequency brain activity taking cognitive performance as epitome, especially in people without seizures.

Current electrocorticography data come from limited, diverse and complex cases with no gold standards for diseased and normal cortex. I will therefore obtain data from 200 otherwise unguided brain surgeries with different levels of epileptogenicity and cognitive impairment: highly epileptogenic tumors (simple), gliomas (many) and meningiomas which compress healthy brain (uniform; partly without seizures).

I will integrate techniques in a neurosurgical real-time recording and projecting device that simplifies finding and removing epileptogenic tissue to stop the distorting effect in focal brain disorders.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "EPILEPSY_CORE" project.

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The information about "EPILEPSY_CORE" are provided by the European Opendata Portal: CORDIS opendata.

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