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Epilepsy_Core SIGNED

The core and effects of epilepsy: from chronic disease to curable disorder through innovative guided surgery

Total Cost €

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EC-Contrib. €

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Partnership

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 Epilepsy_Core project word cloud

Explore the words cloud of the Epilepsy_Core project. It provides you a very rough idea of what is the project "Epilepsy_Core" about.

tissue    core    cortex    density    population    electrocorticography    generation    gliomas    explore    simplifies    connectivity    epileptogenic    disorders    initiated    adhesive    stochastic    optimize    techniques    sudden    prerequisites    broad    impairment    effect    brain    invasive    appear    cognitive    obtain    evoke    cross    distorting    standards    recording    epileptic    uncover    distorted    solutions    people    seizures    compress    distance    discovered    integrate    tumors    guidance    auto    performance    outcomes    surgeries    time    macrolevel    projecting    unsuccessful    epileptogenicity    markers    disease    hfo    diverse    diseased    susceptible    cure    postsurgical    coupling    functioning    operative    direct    200    innovate    pilot    regression    partly    supervised    otherwise    unguided    stop    radically    epiphenomena    pivotal    surgery    physiological    pinpointing    limited    spreading    microlevel    noise    normal    electrical    versus    reflection    burdens    data    decline       recordings    hfos    frequency    eeg    epitome    device    seizure    oscillations    signal    neurosurgical    focal    meningiomas    gold    healthy    levels    functional    learning    uniform    removing    stimulation    machine    epilepsy    electrodes   

Project "Epilepsy_Core" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAIR MEDISCH CENTRUM UTRECHT 

Organization address
address: HEIDELBERGLAAN 100
city: UTRECHT
postcode: 3584 CX
website: www.umcutrecht.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-03-01   to  2024-02-29

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAIR MEDISCH CENTRUM UTRECHT NL (UTRECHT) coordinator 1˙500˙000.00

Map

 Project objective

Epilepsy burdens 1% of the population. Brain surgery can cure seizures and stop cognitive decline, but it is complex and often unsuccessful. I aim to advance cure from epileptic brain disease radically by 1) pinpointing the core of epilepsy and 2) understanding the effects on normal brain functioning.

High-frequency oscillations (HFOs) are novel markers of the core of focal epilepsy, discovered in long-term invasive EEG. I initiated direct HFO-based guidance of epilepsy surgery with intra-operative invasive electrodes. However, HFOs still appear stochastic epiphenomena. Therefore, I will now uncover the direct microlevel high-frequency EEG reflection of the distorted cortex. I will use three macrolevel signal prerequisites for seizure and HFO generation to innovate intra-operative recording and signal analysis: susceptible (evoke with long-distance electrical stimulation; cross-frequency coupling), sudden (low-noise adhesive electrodes; auto-regression) & spreading (high-density recordings; functional connectivity). I will pilot test technical solutions and optimize analyses with supervised machine learning based on pivotal epileptogenic versus healthy tissue and on postsurgical outcomes. Next, I will explore the broad effect of epileptic on physiological high frequency brain activity taking cognitive performance as epitome, especially in people without seizures.

Current electrocorticography data come from limited, diverse and complex cases with no gold standards for diseased and normal cortex. I will therefore obtain data from 200 otherwise unguided brain surgeries with different levels of epileptogenicity and cognitive impairment: highly epileptogenic tumors (simple), gliomas (many) and meningiomas which compress healthy brain (uniform; partly without seizures).

I will integrate techniques in a neurosurgical real-time recording and projecting device that simplifies finding and removing epileptogenic tissue to stop the distorting effect in focal brain disorders.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "EPILEPSY_CORE" project.

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The information about "EPILEPSY_CORE" are provided by the European Opendata Portal: CORDIS opendata.

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