Opendata, web and dolomites

Epilepsy_Core SIGNED

The core and effects of epilepsy: from chronic disease to curable disorder through innovative guided surgery

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 Epilepsy_Core project word cloud

Explore the words cloud of the Epilepsy_Core project. It provides you a very rough idea of what is the project "Epilepsy_Core" about.

meningiomas    supervised    cortex    uncover    partly    frequency    removing    surgeries    macrolevel    discovered    stop    epitome    tumors    gold    recording    neurosurgical    uniform    disorders    connectivity    cognitive    simplifies    techniques    stochastic    integrate    functional    decline    learning    effect    tissue    versus    population    outcomes    obtain    pinpointing    epileptogenicity    susceptible    otherwise    optimize    machine    time    signal    stimulation    diverse    cross    performance    operative    adhesive    seizure    disease    broad    levels    oscillations    distorting    limited    functioning    impairment    coupling    density    hfo    epileptic    compress    spreading    data    physiological    distorted    appear    evoke    electrodes    prerequisites    sudden    auto    people    seizures    healthy    solutions    recordings    unguided    markers    explore    pivotal       innovate    unsuccessful    reflection    standards    projecting    normal    pilot    diseased    eeg    epiphenomena    radically    epilepsy    cure    invasive    200    microlevel    epileptogenic    guidance    electrical    gliomas    distance    noise    regression    focal    electrocorticography    generation    core    hfos    burdens    surgery    initiated    brain    direct    device    postsurgical   

Project "Epilepsy_Core" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAIR MEDISCH CENTRUM UTRECHT 

Organization address
address: HEIDELBERGLAAN 100
city: UTRECHT
postcode: 3584 CX
website: www.umcutrecht.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-03-01   to  2024-02-29

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAIR MEDISCH CENTRUM UTRECHT NL (UTRECHT) coordinator 1˙500˙000.00

Map

 Project objective

Epilepsy burdens 1% of the population. Brain surgery can cure seizures and stop cognitive decline, but it is complex and often unsuccessful. I aim to advance cure from epileptic brain disease radically by 1) pinpointing the core of epilepsy and 2) understanding the effects on normal brain functioning.

High-frequency oscillations (HFOs) are novel markers of the core of focal epilepsy, discovered in long-term invasive EEG. I initiated direct HFO-based guidance of epilepsy surgery with intra-operative invasive electrodes. However, HFOs still appear stochastic epiphenomena. Therefore, I will now uncover the direct microlevel high-frequency EEG reflection of the distorted cortex. I will use three macrolevel signal prerequisites for seizure and HFO generation to innovate intra-operative recording and signal analysis: susceptible (evoke with long-distance electrical stimulation; cross-frequency coupling), sudden (low-noise adhesive electrodes; auto-regression) & spreading (high-density recordings; functional connectivity). I will pilot test technical solutions and optimize analyses with supervised machine learning based on pivotal epileptogenic versus healthy tissue and on postsurgical outcomes. Next, I will explore the broad effect of epileptic on physiological high frequency brain activity taking cognitive performance as epitome, especially in people without seizures.

Current electrocorticography data come from limited, diverse and complex cases with no gold standards for diseased and normal cortex. I will therefore obtain data from 200 otherwise unguided brain surgeries with different levels of epileptogenicity and cognitive impairment: highly epileptogenic tumors (simple), gliomas (many) and meningiomas which compress healthy brain (uniform; partly without seizures).

I will integrate techniques in a neurosurgical real-time recording and projecting device that simplifies finding and removing epileptogenic tissue to stop the distorting effect in focal brain disorders.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "EPILEPSY_CORE" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "EPILEPSY_CORE" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

evolSingleCellGRN (2019)

Constraint, Adaptation, and Heterogeneity: Genomic and single-cell approaches to understanding the evolution of developmental gene regulatory networks

Read More  

RODRESET (2019)

Development of novel optogenetic approaches for improving vision in macular degeneration

Read More  

IMMUNOTHROMBOSIS (2019)

Cross-talk between platelets and immunity - implications for host homeostasis and defense

Read More