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Platform for label-free quantitative detection of single proteins and extracellular vesicles

Total Cost €


EC-Contrib. €






 IBIS project word cloud

Explore the words cloud of the IBIS project. It provides you a very rough idea of what is the project "IBIS" about.

healthcare    signals    small    made    distributions    transfer    full    reduce    line    characterisation    feedback    plan    focal    balanced    buyers    back    detection    quantitative    poc    free    therapy    benchtop    compact    kda    perceived    extracellular    robustness    sampled    construction    prototype    proteins    commercialization    tailor    grade    biomarkers    signal    microscope    particle    cancer    microscopy    goals    clinical    interference    hence    scheme    commercial    simplification    specialist    neurodegenerative    platform    environment    optimisation    innovation    particles    ibis    vesicle    exosomes    reliably    vesicles    proportional    settings    national    extremely    ultrasensitive    setup    nanoparticles    nanometric    careful    volume    laboratory    definition    binding    invasively    diagnostics    label    sensitivity    guided    size    strategy    scattering    mask    optical    market    15    ip    attenuation    fight    plane    detectors    diseases    implementations    single    quantify    positioning   

Project "IBIS" data sheet

The following table provides information about the project.


Organization address
city: Castelldefels
postcode: 8860

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 150˙000 €
 EC max contribution 150˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-PoC
 Funding Scheme ERC-POC
 Starting year 2017
 Duration (year-month-day) from 2017-09-01   to  2019-02-28


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACIO INSTITUT DE CIENCIES FOTONIQUES ES (Castelldefels) coordinator 150˙000.00


 Project objective

The main objective of the IBIS project is to develop an ultrasensitive, compact and low cost platform for the label-free quantitative detection of single proteins, and specifically the characterisation of nanometric extracellular vesicles. We will develop a prototype to transfer our novel detection scheme from the laboratory to the clinical environment and, based on user-feedback, develop a commercialization plan. In the fight against cancer and neurodegenerative diseases, exosomes are being perceived as potential biomarkers that can be sampled non-invasively. Reliable quantitative detection and analysis is needed to exploit the full potential of exosomes in diagnostics and therapy. The proposed innovation comprises a novel all optical approach: In-line Balanced Interference Scattering (IBIS). The balanced detection is implemented by a tailor-made attenuation mask into the back-focal-plane of a microscope, allowing the detection of particles as small as 15 kDa. The IBIS signal is directly proportional to the particle volume and can hence be used to quantify size distributions of nanoparticles reliably. IBIS microscopy only requires low-cost consumer grade detectors and an extremely simple optical setup. Specific goals of this proposed PoC project are: (i) Simplification of the current laboratory implementation to improve robustness and further reduce the cost, (ii) Careful characterisation of extracellular vesicle signals and binding behaviour under laboratory conditions, (iii) Construction of a compact benchtop prototype and implementation under clinical conditions, (iv) Feedback guided optimisation of the prototype by comparing laboratory (high sensitivity, specialist) and clinical (reduced sensitivity, non-specialist) results, (v) Design-optimisation of commercial implementations based on market research from clinical settings and national healthcare buyers. Definition of IP and market positioning and strategy.

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The information about "IBIS" are provided by the European Opendata Portal: CORDIS opendata.

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