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IBIS

Platform for label-free quantitative detection of single proteins and extracellular vesicles

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 IBIS project word cloud

Explore the words cloud of the IBIS project. It provides you a very rough idea of what is the project "IBIS" about.

commercialization    vesicles    focal    biomarkers    hence    specialist    settings    optical    feedback    scheme    interference    nanometric    characterisation    microscope    ultrasensitive    guided    exosomes    binding    ip    platform    invasively    market    mask    extracellular    label    sampled    national    quantitative    signals    small    innovation    volume    definition    grade    distributions    scattering    robustness    compact    simplification    sensitivity    setup    balanced    vesicle    tailor    clinical    laboratory    diagnostics    detectors    size    proteins    careful    therapy    reliably    buyers    15    plan    plane    implementations    detection    perceived    construction    proportional    strategy    optimisation    goals    reduce    back    extremely    environment    free    prototype    cancer    attenuation    ibis    kda    particles    fight    poc    single    full    positioning    particle    transfer    quantify    line    microscopy    healthcare    neurodegenerative    benchtop    signal    made    commercial    nanoparticles    diseases   

Project "IBIS" data sheet

The following table provides information about the project.

Coordinator
FUNDACIO INSTITUT DE CIENCIES FOTONIQUES 

Organization address
address: AVINGUDA CARL FRIEDRICH GAUSS 3
city: Castelldefels
postcode: 8860
website: www.icfo.eu

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 150˙000 €
 EC max contribution 150˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-PoC
 Funding Scheme ERC-POC
 Starting year 2017
 Duration (year-month-day) from 2017-09-01   to  2019-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACIO INSTITUT DE CIENCIES FOTONIQUES ES (Castelldefels) coordinator 150˙000.00

Map

 Project objective

The main objective of the IBIS project is to develop an ultrasensitive, compact and low cost platform for the label-free quantitative detection of single proteins, and specifically the characterisation of nanometric extracellular vesicles. We will develop a prototype to transfer our novel detection scheme from the laboratory to the clinical environment and, based on user-feedback, develop a commercialization plan. In the fight against cancer and neurodegenerative diseases, exosomes are being perceived as potential biomarkers that can be sampled non-invasively. Reliable quantitative detection and analysis is needed to exploit the full potential of exosomes in diagnostics and therapy. The proposed innovation comprises a novel all optical approach: In-line Balanced Interference Scattering (IBIS). The balanced detection is implemented by a tailor-made attenuation mask into the back-focal-plane of a microscope, allowing the detection of particles as small as 15 kDa. The IBIS signal is directly proportional to the particle volume and can hence be used to quantify size distributions of nanoparticles reliably. IBIS microscopy only requires low-cost consumer grade detectors and an extremely simple optical setup. Specific goals of this proposed PoC project are: (i) Simplification of the current laboratory implementation to improve robustness and further reduce the cost, (ii) Careful characterisation of extracellular vesicle signals and binding behaviour under laboratory conditions, (iii) Construction of a compact benchtop prototype and implementation under clinical conditions, (iv) Feedback guided optimisation of the prototype by comparing laboratory (high sensitivity, specialist) and clinical (reduced sensitivity, non-specialist) results, (v) Design-optimisation of commercial implementations based on market research from clinical settings and national healthcare buyers. Definition of IP and market positioning and strategy.

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The information about "IBIS" are provided by the European Opendata Portal: CORDIS opendata.

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