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SYN1002

A New Therapeutic Option to Protect Central Nervous System against Acute Ischemic Stroke

Total Cost €

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EC-Contrib. €

0

Partnership

0

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 SYN1002 project word cloud

Explore the words cloud of the SYN1002 project. It provides you a very rough idea of what is the project "SYN1002" about.

auto    treat    deal    qualify    2012    orphit    six    ischemic    iia    market    ais    business    institutes    treatment    265m    company    millions    plan    inflammatory    400m    stoke    doses    pathologies    patients    strokes    acute    neuroprotective    confirming    limited    complement       immune    suitable    event    drug    preclinical    activator    sales    solution    million    syn1002    tissue    experiencing    time    stroke    seed    neuronal    stage    peptide    match    applicable    administered    2017    tolerability    clinical    proof    rtpa    of    protect    potent    safety    substance    pioneer    industry    window    approved    causing    biotech    share    treatments    initially    health    pharmaceutical    each    disability    net    agent    framework    intends    positioning    16    draw    larger    indication    world    deaths    anti    patient    documenting    persons    ongoing    suffering    efficient    therapeutic    2026    perfect    multiple    safe    markets    feasibility    search    peak    successfully    licensing    damage    50    plasminogen    realize    billion    permanent    thrombolytic    recombinant   

Project "SYN1002" data sheet

The following table provides information about the project.

Coordinator
ORPHIT 

Organization address
address: 1093 CHEMIN DES PLATEAUX FLEURIS RESIDENCES PANORA LA B
city: SAINT-LAURENT-DU-VAR
postcode: 6700
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Project website http://www.orphitpharma.com
 Total cost 71˙429 €
 EC max contribution 50˙000 € (70%)
 Programme 1. H2020-EU.2.1.4. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Biotechnology)
2. H2020-EU.2.3.1. (Mainstreaming SME support, especially through a dedicated instrument)
 Code Call H2020-SMEINST-1-2016-2017
 Funding Scheme SME-1
 Starting year 2017
 Duration (year-month-day) from 2017-08-01   to  2018-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ORPHIT FR (SAINT-LAURENT-DU-VAR) coordinator 50˙000.00

Map

 Project objective

Each year, about 16 million strokes occur in the world causing millions of deaths and one third of patients experiencing permanent disability. The main treatment of stroke is thrombolytic agent recombinant tissue plasminogen activator (rtPA). Not all the patient can qualify for this treatment and it can be administered only in a limited time window. No existing drug is approved to protect against ongoing neuronal damage after the acute event. In this framework, our company, ORPHIT, a seed-stage biotech company, intends to be a pioneer by bringing clinical proof of concept of our peptide SYN1002 as suitable neuroprotective anti-inflammatory agent to treat stoke in acute phase that could be administered at multiple doses as complement to current thrombolytic treatments and also in patients who do not qualify for treatment with rtPA. This peptide is our lead product and has been initially developed as a potent anti-inflammatory substance in auto-immune pathologies with a clinical phase 1 study successfully documenting the safety and tolerability. Its properties make it a perfect match with current needs on Stroke treatment. Therefore, our solution is of interest for the pharmaceutical industry and health institutes who are currently in the search of a treatment that would be efficient and safe enough to be applicable to a larger part of the persons suffering from Stroke. The acute ischemic stroke (AIS) therapeutic market generated 400M€ in 2012 across the six major markets and is expected to reach 1.1 billion € by the end of 2017. SYN1002 sales at peak (2026) are expected to achieve 50% of market share, and a licensing deal at end of phase IIa would come out with a net present value of 265M€ for our company. In order to achieve this goal ORPHIT will realize a feasibility study aiming at strengthening SYN1002 preclinical package in AIS indication, confirming drug positioning through in depth market study, and draw a European business plan.

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The information about "SYN1002" are provided by the European Opendata Portal: CORDIS opendata.

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