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TAPAS SIGNED

TArgeting Platelet Adhesion receptors in thrombosiS

Total Cost €

0

EC-Contrib. €

0

Partnership

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 TAPAS project word cloud

Explore the words cloud of the TAPAS project. It provides you a very rough idea of what is the project "TAPAS" about.

activation    safe    shared    critical    qualified    haemostasis    thrombotic    patients    analytical    broad    small    15    heart    ideally    microscopy    diseased    generate    cohort    integrate    disciplines    co    undertaken    contemporary    scientists    undergo    innovative    anti    episodes    disciplinary    excessive    diseases    prevention    thrombosis    century    operation    vessels    esrs    omics    injury    serious    gives    day    original    biologics    biomedical    bleeding    applicable    cell    forefront    thromboinflammation    training    convert    platelets    medicines    close    skills    inhibit    risk    ways    morbidity    platelet    transferable    position    beneficiaries    throughput    screens    therapeutic    encounter    causes    bleeds    mortality    intervention    microfluidics    stroke    life    urgent    interaction    academic    private    ejd    cells    uniquely    vivo    preserve    train    disorders    prevent    experts    biological    diminished    blood    powerfully    modern    models    tapas    intersectorial    attack    21st    compounds    biology    equip    play    suited   

Project "TAPAS" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF BIRMINGHAM 

Organization address
address: Edgbaston
city: BIRMINGHAM
postcode: B15 2TT
website: www.bham.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 3˙881˙891 €
 EC max contribution 3˙881˙891 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2017
 Funding Scheme MSCA-ITN-EJD
 Starting year 2018
 Duration (year-month-day) from 2018-01-01   to  2021-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF BIRMINGHAM UK (BIRMINGHAM) coordinator 546˙575.00
2    UNIVERSITEIT MAASTRICHT NL (MAASTRICHT) participant 1˙021˙497.00
3    THE UNIVERSITY OF READING UK (READING) participant 819˙863.00
4    LEIBNIZ-INSTITUT FUR ANALYTISCHE WISSENSCHAFTEN-ISAS-EV DE (DORTMUND) participant 498˙432.00
5    UNIVERSITAETSKLINIKUM WUERZBURG - KLINIKUM DER BAYERISCHEN JULIUS-MAXIMILIANS-UNIVERSITAT DE (WURZBURG) participant 498˙432.00
6    ALACRIS THERANOSTICS GMBH DE (BERLIN) participant 249˙216.00
7    UNIVERSIDAD DE SANTIAGO DE COMPOSTELA ES (SANTIAGO DE COMPOSTELA) participant 247˙872.00
8    CELLIX LIMITED IE (Dublin) partner 0.00
9    Intelligent Imaging Innovations GmbH DE (Göttingen) partner 0.00
10    Nikon Instruments Europe NL (AMSTERDAM) partner 0.00
11    PIVOT PARK SCREENING CENTRE BV NL (OSS) partner 0.00
12    SEMMELWEIS EGYETEM HU (BUDAPEST) partner 0.00
13    SVEUCILISTE U RIJECI HR (RIJEKA) partner 0.00

Map

 Project objective

TAPAS will position Europe at the forefront of innovative research to prevent thrombosis and thromboinflammation, and will train a uniquely-qualified cohort of ESRs in a highly intersectorial and multi-disciplinary programme that will equip them with the knowledge and transferable skills required in the broad biomedical sector. The research will focus on platelets which are small cells in the blood that play a critical role in prevention of excessive bleeding following injury (haemostasis). Activation of platelets in diseased vessels gives rise to thrombotic disorders such as heart attack and stroke, two of the major causes of morbidity and mortality. Patients at risk of thrombosis are treated with medicines that inhibit platelets for life, but many patients still undergo thrombotic episodes or encounter serious bleeds through diminished haemostasis. There is thus an urgent need for novel and safe anti-platelet medicines that powerfully target thrombosis but preserve haemostasis. In TAPAS, an original and innovative approach will be undertaken to find new ways to target thrombosis through co-operation of academic experts in distinct disciplines with key skills from the private sector. TAPAS will generate and integrate knowledge from analytical complex ‘omics’, advanced microscopy, cell biology, microfluidics, in vivo models, contemporary systems biology and high throughput screens to identify new targets for therapeutic intervention and novel lead compounds or biologics. The research skills developed in this programme are applicable to other complex diseases and represent essential training in modern day research for the next cohort of academic and private sector scientists that are able to convert complex biological understanding into new medicines. The shared knowledge and close interaction between beneficiaries and partners makes this programme ideally suited to an EJD and will deliver 15 ESRs in 21st century biomedical research.

 Deliverables

List of deliverables.
Dissemination and Outreach activity plan completed Other 2020-04-16 14:17:18
Recruitment of 15 ESRs (with statistics of applications) Other 2020-04-16 14:17:12
Organisation of first European Summer School Other 2020-04-16 14:17:02
Organisation of Training Workshops and Conferences Other 2020-04-16 14:16:57
Progress report Documents, reports 2020-04-16 14:17:22
Setup of TAPAS website (updates every 6 months) Websites, patent fillings, videos etc. 2020-04-16 14:17:07

Take a look to the deliverables list in detail:  detailed list of TAPAS deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 Sanne L.N. Brouns, Isabella Provenzale, Johanna P. van Geffen, Paola E. van der Meijden, Johan W.M. Heemskerk
Localised endothelial‐based control of platelet aggregation and coagulation under flow: a proof‐of‐principle vessel‐on‐a‐chip study
published pages: , ISSN: 1538-7933, DOI: 10.1111/jth.14719
Journal of Thrombosis and Haemostasis 2020-02-19
2019 Isabella Provenzale, Sanne L. N. Brouns, Paola E. J. van der Meijden, Frauke Swieringa, Johan W. M. Heemskerk
Whole Blood Based Multiparameter Assessment of Thrombus Formation in Standard Microfluidic Devices to Proxy In Vivo Haemostasis and Thrombosis
published pages: 787, ISSN: 2072-666X, DOI: 10.3390/mi10110787
Micromachines 10/11 2020-01-14
2019 Joanne L. Dunster, Amanda J. Unsworth, Alexander P. Bye, Elizabeth J Haining, Marcin A. Sowa, Ying Di, Tanya Sage, Chiara Pallini, Jeremy A. Pike, Alexander.T. Hardy, Bernhard Nieswandt, Ángel García, Steve P. Watson, Natalie S. Poulter, Jonathan M. Gibbins, Alice Y. Pollitt
Interspecies differences in protein expression do not impact the spatiotemporal regulation of GPVI mediated activation
published pages: , ISSN: 1538-7933, DOI: 10.1111/jth.14673
Journal of Thrombosis and Haemostasis 2019-12-16
2019 Natalie J. Jooss, Ilaria De Simone, Isabella Provenzale, Delia I. Fernández, Sanne L.N. Brouns, Richard W. Farndale, Yvonne M.C. Henskens, Marijke J.E. Kuijpers, Hugo ten Cate, Paola E.J. van der Meijden, Rachel Cavill, Johan W.M. Heemskerk
Role of Platelet Glycoprotein VI and Tyrosine Kinase Syk in Thrombus Formation on Collagen-Like Surfaces
published pages: 2788, ISSN: 1422-0067, DOI: 10.3390/ijms20112788
International Journal of Molecular Sciences 20/11 2019-09-26

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The information about "TAPAS" are provided by the European Opendata Portal: CORDIS opendata.

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