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Catalytic Dual-Function Devices Against Cancer

Total Cost €


EC-Contrib. €






 CADENCE project word cloud

Explore the words cloud of the CADENCE project. It provides you a very rough idea of what is the project "CADENCE" about.

remotely    seem    tissues    little    reached    causes    catalytic    catalysis    made    passive    heterogeneous    mainly    cancer    epr    bio    cadence    intense    explore    partial    near    selective    despite    affords    cells    kinetics    hypothesis    specificity    optimized    reactions    tools    death    highest    perspective    difficulties    chemical    orthogonal    catalysts    discipline    heat    remote    special    attributed    borrowed    stem    almost    tested    ideas    engineering    chemistry    reactor    depleted    locally    once    treat    therapy    toolbox    activated    horses    core    nir    therapeutic    body    natural    remarkable    drug    effect    activation    infrared    strategies    central    least    penetration    mass    situ    practical    continues    otherwise    overcome    tumour    function    worldwide    lived    catalyst    branch    environments    transfer    breakthrough    trojan    sciences    noted    toxic    light    vivo    efforts    molecules    reaction   

Project "CADENCE" data sheet

The following table provides information about the project.


Organization address
postcode: 50009

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 2˙483˙136 €
 EC max contribution 2˙483˙136 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-ADG
 Funding Scheme ERC-ADG
 Starting year 2017
 Duration (year-month-day) from 2017-09-01   to  2022-08-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDAD DE ZARAGOZA ES (ZARAGOZA) coordinator 2˙483˙136.00


 Project objective

Despite intense research efforts in almost every branch of the natural sciences, cancer continues to be one of the leading causes of death worldwide. It is thus remarkable that little or no therapeutic use has been made of a whole discipline, heterogeneous catalysis, which is noted for its specificity and for enabling chemical reactions in otherwise passive environments. At least in part, this could be attributed to practical difficulties: the selective delivery of a catalyst to a tumour and the remote activation of its catalytic function only after it has reached its target are highly challenging objectives. Only recently, the necessary tools to overcome these problems seem within reach. CADENCE aims for a breakthrough in cancer therapy by developing a new therapeutic concept. The central hypothesis is that a growing tumour can be treated as a special type of reactor in which reaction conditions can be tailored to achieve two objectives: i) molecules essential to tumour growth are locally depleted and ii) toxic, short-lived products are generated in situ. To implement this novel approach we will make use of core concepts of reactor engineering (kinetics, heat and mass transfer, catalyst design), as well as of ideas borrowed from other areas, mainly those of bio-orthogonal chemistry and controlled drug delivery. We will explore two different strategies (classical EPR effect and stem cells as Trojan Horses) to deliver optimized catalysts to the tumour. Once the catalysts have reached the tumour they will be remotely activated using near-infrared (NIR) light, that affords the highest penetration into body tissues. This is an ambitious project, addressing all the key steps from catalyst design to in vivo studies. Given the novel perspective provided by CADENCE, even partial success in any of the approaches to be tested would have a significant impact on the therapeutic toolbox available to treat cancer.


year authors and title journal last update
List of publications.
2020 M. Carmen Ortega-Liebana, Javier Bonet-Aleta, Jose L. Hueso and Jesus Santamaria
Gold-based nanoparticles on amino-functionalized mesoporous silica supports as nanozymes forglucose oxidation
published pages: , ISSN: 2073-4344, DOI: 10.3390/catal10030333
Catalysis Catalysts 2020, 10, 333 2020-03-24
2019 Hugo Suarez, Adrian Ramirez, Carlos J. Bueno-Alejo, Jose L. Hueso
Silver-Copper Oxide Heteronanostructures for the Plasmonic-Enhanced Photocatalytic Oxidation of N-Hexane in the Visible-NIR Range
published pages: 3858, ISSN: 1996-1944, DOI: 10.3390/ma12233858
Materials 12/23 2019-12-17
2019 Bruno Bottega-Pergher, Javier Graus, Carlos J. Bueno-Alejo, Jose L. Hueso
Triangular and Prism-Shaped Gold-Zinc Oxide Plasmonic Nanostructures: In situ Reduction, Assembly, and Full-Range Photocatalytic Performance
published pages: 3228-3234, ISSN: 1434-1948, DOI: 10.1002/ejic.201900213
European Journal of Inorganic Chemistry 2019/27 2019-10-29
2019 María Sancho-Albero, Maria del Mar Encabo-Berzosa, Manuel Beltrán-Visiedo, Lola Fernández-Messina, Víctor Sebastián, Francisco Sánchez-Madrid, Manuel Arruebo, Jesús Santamaría, Pilar Martín-Duque
Efficient encapsulation of theranostic nanoparticles in cell-derived exosomes: leveraging the exosomal biogenesis pathway to obtain hollow gold nanoparticle-hybrids
published pages: 18825-18836, ISSN: 2040-3364, DOI: 10.1039/c9nr06183e
Nanoscale 11/40 2019-10-29
2020 Nuria Mas, Jose L. Hueso, Gema Martinez, Ainhoa Madrid, Reyes Mallada, M. Carmen Ortega-Liebana, Carlos Bueno-Alejo, Jesus Santamaria
Laser-driven direct synthesis of carbon nanodots and application as sensitizers for visible-light photocatalysis
published pages: 453-462, ISSN: 0008-6223, DOI: 10.1016/j.carbon.2019.09.073
Carbon 156 2019-10-29
2019 María Sancho-Albero, Belén Rubio-Ruiz, Ana M. Pérez-López, Víctor Sebastián, Pilar Martín-Duque, Manuel Arruebo, Jesús Santamaría, Asier Unciti-Broceta
Cancer-derived exosomes loaded with ultrathin palladium nanosheets for targeted bioorthogonal catalysis
published pages: 864-872, ISSN: 2520-1158, DOI: 10.1038/s41929-019-0333-4
Nature Catalysis 2/10 2019-10-29
2018 Javier Graus, Carlos Bueno-Alejo, Jose Hueso
In-Situ Deposition of Plasmonic Gold Nanotriangles and Nanoprisms onto Layered Hydroxides for Full-Range Photocatalytic Response towards the Selective Reduction of p-Nitrophenol
published pages: 354, ISSN: 2073-4344, DOI: 10.3390/catal8090354
Catalysts 8/9 2019-10-15
2019 M. Carmen Ortega‐Liebana, M. Mar Encabo‐Berzosa, Alvaro Casanova, M. Desiree Pereboom, J. Octavio Alda, Jose L. Hueso, Jesus Santamaria
Upconverting Carbon Nanodots from Ethylenediaminetetraacetic Acid (EDTA) as Near‐Infrared Activated Phototheranostic Agents
published pages: 5539-5546, ISSN: 0947-6539, DOI: 10.1002/chem.201806307
Chemistry – A European Journal 25/21 2019-05-23
2019 María Sancho-Albero, Nuria Navascués, Gracia Mendoza, Víctor Sebastián, Manuel Arruebo, Pilar Martín-Duque, Jesús Santamaría
Exosome origin determines cell targeting and the transfer of therapeutic nanoparticles towards target cells
published pages: ., ISSN: 1477-3155, DOI: 10.1186/s12951-018-0437-z
Journal of Nanobiotechnology 17/1 2019-05-27
2018 M. Carmen Ortega-Liebana, Jose L. Hueso, Rodrigo Fernandez-Pacheco, Silvia Irusta, Jesus Santamaria
Luminescent mesoporous nanorods as photocatalytic enzyme-like peroxidase surrogates
published pages: 7766-7778, ISSN: 2041-6520, DOI: 10.1039/c8sc03112f
Chemical Science 9/40 2019-05-16

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