Opendata, web and dolomites

StroMaP SIGNED

Stromal stress networks underlying phenotypic plasticity and tumor fitness

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 StroMaP project word cloud

Explore the words cloud of the StroMaP project. It provides you a very rough idea of what is the project "StroMaP" about.

implicated    tumors    intervention    hypothesize    stable    phenotypic    malignant    models    me    context    shock    adapt    network    patient    transcription    actionable    discover    immunofluorescence    biology    first    sequencing    rna    tradeoffs    aggressive    landscape    plasticity    tfs    genetic    contribution    hoemostasis    cytoprotective    resolution    reprogrammed    treatments    despite    diversity    cell    diverse    malignancy    massive    heterogeneity    interrogate    view    stroma    progression    rewiring    mouse    tme    space    hsf1    cycles    patients    genomically    malignancies    map    complement    ways    hypothesis    overarching    signatures    single    theory    time    tumor    vital    valuable    epigenetic    co    disease    cells    global    tf    rewired    transcriptional    leads    microenvironment    discovered    evolve    evolution    mice    aggressiveness    heat    tissue    cultures    multiplexed    lack    cancer    activation    stress    outcome    player    heterogeneously    nodes    orchestrated    patterns    reprogramming    generally    evolutionary   

Project "StroMaP" data sheet

The following table provides information about the project.

Coordinator
WEIZMANN INSTITUTE OF SCIENCE 

Organization address
address: HERZL STREET 234
city: REHOVOT
postcode: 7610001
website: www.weizmann.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 1˙499˙990 €
 EC max contribution 1˙499˙990 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-10-01   to  2022-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    WEIZMANN INSTITUTE OF SCIENCE IL (REHOVOT) coordinator 1˙499˙990.00

Map

 Project objective

The contribution of genetic and epigenetic changes to rewiring of cancer cells into their malignant state has been much studied. But tumors are more than cancer cells and the tumor microenvironment (TME) is a key player in tumor progression. We lack an overarching view of how, despite being genomically stable, the TME is heterogeneously reprogrammed across time and space to promote evolution of aggressive disease. Recently I discovered that Heat-Shock Factor 1 (HSF1), a cytoprotective transcription factor (TF), is vital to this reprogramming, promoting malignancy in patients and mice upon activation in the stroma. Other stress TFs have also been implicated. This leads me to hypothesize that stress responses help tumors adapt and evolve into aggressive malignancies, by enabling heterogeneity and phenotypic diversity in the TME. This plasticity is achieved through cycles of massive transcriptional rewiring orchestrated by a network of stress TFs. To test this hypothesis in a global way we will proceed in three aims. First we will define patterns of stress response activation in the TME by multiplexed immunofluorescence of patient tumors. Then, we will map the associated transcriptional landscape in patients by RNA-sequencing down to single cell resolution and interrogate it in the context of a novel theory of evolutionary tradeoffs so as to discover signatures that promote tumor aggressiveness. Next, we will identify actionable nodes for intervention and test them in cell co-cultures and mouse models. The expected outcome of the proposed research is a detailed network of stress responses that can explain how the TME is rewired in tumors and how variable this rewiring is. This knowledge will provide new ways to target the TME in order to complement treatments focused on cancer cells. More generally, we address key aspects of stress responses, tissue plasticity, hoemostasis and evolution that are expected to be valuable across diverse fields of biology.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "STROMAP" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "STROMAP" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

inhibiTOR (2020)

Novel selective mTORC1 inhibitors

Read More  

ARCTIC (2020)

Air Transport as Information and Computation

Read More  

E-DIRECT (2020)

Evolution of Direct Reciprocity in Complex Environments

Read More