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4D-GenEx SIGNED

Spatio-temporal Organization and Expression of the Genome

Total Cost €

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EC-Contrib. €

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Partnership

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 4D-GenEx project word cloud

Explore the words cloud of the 4D-GenEx project. It provides you a very rough idea of what is the project "4D-GenEx" about.

pathological    competition    physical    pairs    recycling    coordinate    ms2    pp7    combines    statistical    dynamics    labeling    relationship    genome    biology    modeling    uncover    cluster    communicate    interface    edge    signal    critically    live    co    compartments    microenvironment    noise    local    positions    tracking    spatio    cutting    mechanisms    regulation    enhancers    perturbations    patterns    hi    responsive    linear    investigates    experimental    physics    experiment    underlying    tools    innovative    coupling    hormone    computer    dual    transcription    acting    fish    domain    motion    coordinated    first    extract    shared    locus    imaging    conformational    molecule    single    organizing    individual    rna    transcriptional    theory    data    space    organization    genes    normal    building    analytical    dimensions    regulated    temporal    expertise    responding    understand    4d    probing    gene    functional    science    visualize    indicates    certain    hypothesis    nucleus    subnuclear    chromosomes    cellular    supercoiling    stochastic    relates    preferred    validate    relation    lack    color    appropriate    shape    suggest    interpreting    impairing    time    expression    signatures   

Project "4D-GenEx" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙499˙750 €
 EC max contribution 1˙499˙750 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-04-01   to  2023-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 1˙499˙750.00

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 Project objective

This project investigates the two-way relationship between spatio-temporal genome organization and coordinated gene regulation, through an approach at the interface between physics, computer science and biology.

In the nucleus, preferred positions are observed from chromosomes to single genes, in relation to normal and pathological cellular states. Evidence indicates a complex spatio-temporal coupling between co-regulated genes: e.g. certain genes cluster spatially when responding to similar factors and transcriptional noise patterns suggest domain-wide mechanisms. Yet, no individual experiment allows probing transcriptional coordination in 4 dimensions (FISH, live locus tracking, Hi-C...). Interpreting such data also critically requires theory (stochastic processes, statistical physics…). A lack of appropriate experimental/analytical approaches is impairing our understanding of the 4D genome.

Our proposal combines cutting-edge single-molecule imaging, signal-theory data analysis and physical modeling to study how genes coordinate in space and time in a single nucleus. Our objectives are to understand (a) competition/recycling of shared resources between genes within subnuclear compartments, (b) how enhancers communicate with genes domain-wide, and (c) the role of local conformational dynamics and supercoiling in gene co-regulation. Our organizing hypothesis is that, by acting on their microenvironment, genes shape their co-expression with other genes.

Building upon my expertise, we will use dual-color MS2/PP7 RNA labeling to visualize for the first time transcription and motion of pairs of hormone-responsive genes in real time. With our innovative signal analysis tools, we will extract spatio-temporal signatures of underlying processes, which we will investigate with stochastic modeling and validate through experimental perturbations. We expect to uncover how the functional organization of the linear genome relates to its physical properties and dynamics in 4D.

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The information about "4D-GENEX" are provided by the European Opendata Portal: CORDIS opendata.

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