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IMBIBE SIGNED

Innovative technology solutions to explore effects of the microbiome on intestine and brain pathophysiology

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 IMBIBE project word cloud

Explore the words cloud of the IMBIBE project. It provides you a very rough idea of what is the project "IMBIBE" about.

immunity    gastrointestinal    bacteria    microbes    engineering    monitoring    decade    pace    cell    interactions    iterative    platform    assessing    capture    models    health    throughput    microbe    3d    animal    appears    transformative    unquestionable    linked    spectrum    edge    questioned    diabetes    truly    time    demonstrated    benefitting    relevance    cancer    human    host    stress    crohn    metabolism    pressure    disease    science    turn    replacement    intestinal    nutrient    gi    appropriate    alterations    absorption    function    benefit    obesity    energy    culture    autism    animals    ethics    vitro    imbibe    singularly    tract    employed    materials    sole    neuropathologies    asd    pathophysiology    disorder    improvements    organic    types    complete    though    microbiota    situation    viability    colorectal    phenotypes    microbiome    basic    gut    barrier    alternatives    anxiety    refinement    replaced    cutting    trillion    accelerated    brain    electronic   

Project "IMBIBE" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE 

Organization address
address: TRINITY LANE THE OLD SCHOOLS
city: CAMBRIDGE
postcode: CB2 1TN
website: www.cam.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 1˙992˙578 €
 EC max contribution 1˙992˙578 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-COG
 Funding Scheme ERC-COG
 Starting year 2017
 Duration (year-month-day) from 2017-10-01   to  2022-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) coordinator 1˙992˙578.00

Map

 Project objective

The human gut is host to over 100 trillion bacteria that are known to be essential for human health. Intestinal microbes can affect the function of the gastrointestinal (GI) tract, via immunity, nutrient absorption, energy metabolism and intestinal barrier function. Alterations in the microbiome have been linked with many disease phenotypes including colorectal cancer, Crohn’s disease, obesity, diabetes as well as neuropathologies such as autism spectrum disorder (ASD), stress and anxiety. Animal studies remain one of the sole means of assessing the importance of microbiota on development and well-being, however the use of animals to study human systems is increasingly questioned due to ethics, cost and relevance concerns. In vitro models have developed at an accelerated pace in the past decade, benefitting from advances in cell culture (in particular 3D cell culture and use of human cell types), increasing the viability of these systems as alternatives to traditional cell culture methods. This in turn will allow refinement and replacement of animal use. In particular in basic science, or high throughput approaches where animal models are under significant pressure to be replaced, in vitro human models can be singularly appropriate. The development of in vitro models with microbiota has not yet been demonstrated even though the transformative role of the microbiota appears unquestionable. The IMBIBE project will focus on using engineering and materials science approaches to develop complete (i.e. human and microbe) in vitro models to truly capture the human situation. IMBIBE will benefit from cutting edge organic electronic technology which will allow real-time monitoring thus enabling iterative improvements in the models employed. The result from this project will be a platform to study host-microbiome interactions and consequences for pathophysiology, in particular, of the GI tract and brain.

 Publications

year authors and title journal last update
List of publications.
2018 Jonathan Rivnay, Sahika Inal, Alberto Salleo, Róisín M. Owens, Magnus Berggren, George G. Malliaras
Organic electrochemical transistors
published pages: 17086, ISSN: 2058-8437, DOI: 10.1038/natrevmats.2017.86
Nature Reviews Materials 3/2 2020-01-16
2018 C. Pitsalidis, M. P. Ferro, D. Iandolo, L. Tzounis, S. Inal, R. M. Owens
Transistor in a tube: A route to three-dimensional bioelectronics
published pages: eaat4253, ISSN: 2375-2548, DOI: 10.1126/sciadv.aat4253
Science Advances 4/10 2020-01-16

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