Opendata, web and dolomites


Miniaturized automated patch-clamp system combined with high-density microelectrode arrays for multi-scale functional mapping of neuronal networks

Total Cost €


EC-Contrib. €






 MAPSYNE project word cloud

Explore the words cloud of the MAPSYNE project. It provides you a very rough idea of what is the project "MAPSYNE" about.

temporal    sclerosis    record    combining    local    density    neurons    meas    cure    hardware    spatial    million    https    diseases    europa    parallel    synaptic    als    suffer    failures    arrays    label    more    scales    recording    axons    neuronal    microelectrode    phases    vitro    pluripotent    stem    thousands    people    model    propagating    potentials    functional    preclinical    track    societies    ipsc    health    cultures    commercialization    patch    human    software    repeated    technologies    dysfunction    aging    single    events    hd    disease    neurodegenerative    drugs    alzheimer    networks    designed    165    healthcare    experiments    aps    signals    lateral    miniaturized    network    ec    amyotrophic    trials    er    mapsyne    clamp    demand    detection    clinical    drug    proof    free    blockers    electrical    nervous    mapping    cells    compartments    mini    assays    cell    parkinson    central    combined    billion    cns    screening    action    automated    envisions    brain    discovery    patching    primary    worldwide   

Project "MAPSYNE" data sheet

The following table provides information about the project.


Organization address
city: ZURICH
postcode: 8047
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 187˙419 €
 EC max contribution 187˙419 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-SE
 Starting year 2018
 Duration (year-month-day) from 2018-12-01   to  2020-11-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAXWELL BIOSYSTEMS AG CH (ZURICH) coordinator 187˙419.00


 Project objective

More than one billion people worldwide (165 million in Europe) suffer from diseases of the central nervous system (CNS). With Europe's aging societies, the European Commission identified brain research as one of the key research areas under healthcare ( Many neurodegenerative diseases are still without cure (e.g., Parkinson’s, amyotrophic lateral sclerosis (ALS) and Alzheimer’s) and repeated failures in clinical trials increase the demand for novel screening technologies to be implemented in the early phases of drug discovery.

Recent studies show that synaptic dysfunction is involved in CNS diseases. New technologies for neuronal screening targeting synaptic and network activity, combined with disease model cells in vitro, will enable novel functional assays for CNS drug discovery. This project aims to develop MAPSYNE, a Miniaturized Automated Patch-clamp SYstem combined with high-density microelectrode arrays (HD-MEAs) for multi-scale functional mapping of NEuronal networks. Patch-clamp allows detection of synaptic events and action potentials (APs) of single cells, while HD-MEAs record APs of thousands of neurons in parallel (also track APs propagating along axons). Combining the two methods will allow access to neuronal electrical signals across spatial and temporal scales.

MAPSYNE's main objectives are (1) the development of hardware and software for a fully automated mini-patching system on HD-MEAs and (2) proof-of-concept experiments using primary and human induced pluripotent stem cell (h-iPSC)-derived neuronal networks.

MAPSYNE will be designed for long-term, label-free recording of cell cultures. Other applications include local application of drugs (e.g, synaptic blockers on neuronal compartments). After this project, the ER envisions the commercialization of MAPSYNE, and eventually, its usage for preclinical CNS drug discovery.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "MAPSYNE" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email ( and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "MAPSYNE" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

NaWaTL (2020)

Narrative, Writing, and the Teotihuacan Language: Exploring Language History Through Phylogenetics, Epigraphy and Iconography

Read More  

RegARcis (2020)

Role of the SWI/SNF complex in the Androgen Receptor cistrome regulation

Read More  

PNAIC (2018)

Positive and Negative Asymmetry in Intergroup Contact: Its Impact on Linguistic Forms of Communication and Physiological Responses

Read More