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CSI-Fun SIGNED

Chronic Systemic Inflammation: Functional organ cross-talk in inflammatory disease and cancer

Total Cost €

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EC-Contrib. €

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Partnership

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Project "CSI-Fun" data sheet

The following table provides information about the project.

Coordinator
MEDIZINISCHE UNIVERSITAET WIEN 

Organization address
address: SPITALGASSE 23
city: WIEN
postcode: 1090
website: www.meduniwien.ac.at

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Total cost 2˙499˙875 €
 EC max contribution 2˙499˙875 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-ADG
 Funding Scheme ERC-ADG
 Starting year 2018
 Duration (year-month-day) from 2018-06-01   to  2023-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MEDIZINISCHE UNIVERSITAET WIEN AT (WIEN) coordinator 2˙499˙875.00
2    FUNDACION CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III ES (MADRID) participant 0.00

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 Project objective

Chronic Systemic Inflammation (CSI) resulting from systemic release of inflammatory cytokines and activation of the immune system is responsible for the progression of several debilitating diseases, such as Psoriasis, Arthritis and Cancer. Initially localised diseases can result in CSI with subsequent systemic spread to distant organs, a key patho-physiological phase responsible for major morbidity and even mortality. Despite the importance of CSI, a complete understanding of the molecular mechanisms, signalling pathways and cell types involved, as well as the chronological evolution of the systemic inflammatory response is still elusive. The classical approach to study inflammation has focused on investigating individual cell types or organs in the pathogenesis of a single disease, thereby neglecting important organ cross-talk and systemic interactions. Furthermore, understanding the temporal and spatial kinetics modulating the inflammatory response requires a detailed study of interactions between different immune and non-immune organs at various time points during disease progression in the context of the whole organism. The aim of this research proposal is to substantially advance our understanding of whole organ physiology in relation to systemic inflammation as a cause or/and consequence of disease with the focus on Psoriasis/Joint Diseases and Cancer Cachexia. The goal is to elucidate the molecular mechanisms at the cellular and systemic level, and to decipher endocrine interactions and cross-talks between distant organs. Various model systems ranging from cell cultures to genetically engineered mouse models to human clinical samples will be employed. Genomic, proteomic and metabolomic data will be combined with functional in vivo assessment using mouse models to understand the multi-faceted role of systemic inflammation in chronic human diseases, such as Inflammatory Skin/Joint disease and Cachexia, a deadly systemic manifestation of Cancer.

 Publications

year authors and title journal last update
List of publications.
2018 Ana Soler-Cardona, Agnes Forsthuber, Katharina Lipp, Stefanie Ebersberger, Magdalena Heinz, Klaudia Schossleitner, Elisabeth Buchberger, Marion Gröger, Peter Petzelbauer, Christoph Hoeller, Erwin Wagner, Robert Loewe
CXCL5 Facilitates Melanoma Cell–Neutrophil Interaction and Lymph Node Metastasis
published pages: 1627-1635, ISSN: 0022-202X, DOI: 10.1016/j.jid.2018.01.035
Journal of Investigative Dermatology 138/7 2020-04-07
2018 Yubin Luo, Bettina Grötsch, Nicole Hannemann, Maria Jimenez, Natacha Ipseiz, Ozge Uluckan, Nengyu Lin, Georg Schett, Erwin F. Wagner, Aline Bozec
Fra-2 Expression in Osteoblasts Regulates Systemic Inflammation and Lung Injury through Osteopontin
published pages: , ISSN: 0270-7306, DOI: 10.1128/mcb.00022-18
Molecular and Cellular Biology 38/22 2020-04-07
2019 Nuria Gago‐Lopez, Liliana F Mellor, Diego Megías, Guillermo Martín‐Serrano, Ander Izeta, Francisco Jimenez, Erwin F Wagner
Role of bulge epidermal stem cells and TSLP signaling in psoriasis
published pages: , ISSN: 1757-4676, DOI: 10.15252/emmm.201910697
EMBO Molecular Medicine 11/11 2020-04-07
2018 Markus Linder, Manfred Hecking, Elisabeth Glitzner, Karin Zwerina, Martin Holcmann, Latifa Bakiri, Maria Grazia Ruocco, Jan Tuckermann, Georg Schett, Erwin F. Wagner, Maria Sibilia
EGFR controls bone development by negatively regulating mTOR-signaling during osteoblast differentiation
published pages: 1094-1106, ISSN: 1350-9047, DOI: 10.1038/s41418-017-0054-7
Cell Death & Differentiation 25/6 2020-04-07
2019 Alvaro C. Ucero, Latifa Bakiri, Ben Roediger, Masakatsu Suzuki, Maria Jimenez, Pratyusha Mandal, Paola Braghetta, Paolo Bonaldo, Luis Paz-Ares, Coral Fustero-Torre, Pilar Ximenez-Embun, Ana Isabel Hernandez, Diego Megias, Erwin F. Wagner
Fra-2–expressing macrophages promote lung fibrosis
published pages: 3293-3309, ISSN: 0021-9738, DOI: 10.1172/jci125366
Journal of Clinical Investigation 129/8 2020-04-07
2019 Özge Uluçkan, Maria Jiménez, Ben Roediger, Jakob Schnabl, Lucía T. Díez-Córdova, Kevin Troulé, Wolfgang Weninger, Erwin F. Wagner
Cutaneous Immune Cell-Microbiota Interactions Are Controlled by Epidermal JunB/AP-1
published pages: 844-859.e3, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2019.09.042
Cell Reports 29/4 2020-04-07
2018 Markus Linder, Elisabeth Glitzner, Sriram Srivatsa, Latifa Bakiri, Kazuhiko Matsuoka, Parastoo Shahrouzi, Monika Dumanic, Philipp Novoszel, Thomas Mohr, Oliver Langer, Thomas Wanek, Markus Mitterhauser, Erwin F Wagner, Maria Sibilia
EGFR is required for FOS‐dependent bone tumor development via RSK2/CREB signaling
published pages: , ISSN: 1757-4676, DOI: 10.15252/emmm.201809408
EMBO Molecular Medicine 10/11 2020-04-07

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