Explore the words cloud of the TTNPred project. It provides you a very rough idea of what is the project "TTNPred" about.
The following table provides information about the project.
|Coordinator Country||Germany [DE]|
|Total cost||171˙460 €|
|EC max contribution||171˙460 € (100%)|
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
|Duration (year-month-day)||from 2018-01-01 to 2020-02-28|
Take a look of project's partnership.
|1||UNIVERSITAT KONSTANZ||DE (KONSTANZ)||coordinator||171˙460.00|
Mutations in the giant muscle protein titin are a major cause of heart disorders in human populations. Routine DNA screening of patient cohorts is now becoming feasible, with a staggering number of titin truncations and missense single nucleotide polymorphisms (mSNPs) rapidly accumulating in genomics databases (>17,000 mSNPs). While the link between titin truncation and disease is now becoming clarified, detecting the pathogenic potential of mSNPs remains a substantial challenge. In mSNPs classification, bioinformatics evaluation is a necessary first filtering step, but existing predictors are poorly reliable. To address this problem, we aim to develop a new titin-centric scoring function that predicts the mechanistic effect of an mSNP exchange in the titin protein by considering the specific characteristics of its poly-domain chain. For this work, we will build a medium-throughput molecular diagnostic pipeline that harvest existent structural models of titin components in estimating mSNPs-induced changes in free energy and conformational dynamics in the protein. Calculations will be benchmarked against experimentally obtained biophysical and biochemical data. To develop this methodology, we will use a clinically pertinent training set of 75 mSNPs. However, in a subsequent step, stable predictions will be extrapolated to the rest of the titin chain by exploiting the repetition of structural and functional loci within the chain. A titin map of vulnerability “hot-spots” so calculated will be distributed to the research community. Ultimately, we aim to produce a tool that can aid clinicians to identify patients at risk of developing a titin-based heart condition at early disease stages, where intervention is still possible.
|year||authors and title||journal||last update|
Yevheniia Nesterenko, Christopher J. Hill, Jennifer R. Fleming, Patricia Murray, Olga Mayans
The ZT Biopolymer: A Self-Assembling Protein Scaffold for Stem Cell Applications
published pages: 4299, ISSN: 1422-0067, DOI: 10.3390/ijms20174299
|International Journal of Molecular Sciences 20/17||2019-09-09|
Christopher J. Hill, Jennifer R. Fleming, Masoumeh Mousavinejad, Rachael Nicholson, Svetomir B. Tzokov, Per A. Bullough, Julius Bogomolovas, Mark R. Morgan, Olga Mayans, Patricia Murray
Self-Assembling Proteins as High-Performance Substrates for Embryonic Stem Cell Self-Renewal
published pages: 1807521, ISSN: 0935-9648, DOI: 10.1002/adma.201807521
Michael Adams, Jennifer R. Fleming, Eva Riehle, Tiankun Zhou, Thomas Zacharchenko, Marija Markovic, Olga Mayans
Scalable, Non-denaturing Purification of Phosphoproteins Using Ga3+-IMAC: N2A and M1M2 Titin Components as Study case
published pages: 181-189, ISSN: 1572-3887, DOI: 10.1007/s10930-019-09815-w
|The Protein Journal 38/2||2019-09-05|
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