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ERACHRON SIGNED

Eradicating Chronic Infections

Total Cost €

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EC-Contrib. €

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Partnership

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 ERACHRON project word cloud

Explore the words cloud of the ERACHRON project. It provides you a very rough idea of what is the project "ERACHRON" about.

sustains    appear    shut    overarching    cellular    small    decades    privileged    ad    phenotype    regulated    ultimately    regulation    fill    intrinsically    tools    molecules    insurgence    experimental    awake    genetically    infections    unaffected    time    virtual    selective    off    resistant    biochemical    biological    community    synergy    sites    combined    resurgence    pathogen    chemical    infection    protein    potent    progression    urgent    molecular    fragment    highlight    antibiotic    elusive    sensitive    eradication    screening    bacterial    upcoming    complementary    chronic    alarming    trigger    operate    sr    suggests    pharmacological    exploitable    play    events    hoc    synthesis    structural    revert    nmr    insensitive    dormant    mechanisms    drug    switch    stringent    cascade    survival    spectroscopy    modulate    last    subpopulation    simply    propensity    gap    predictions    relapsing    chemists    possibly    unravelled    treatment    designed    persister    prevent    reservoir    pivotal    drugs    dynamic    structure    allosterically    tolerant    persisters   

Project "ERACHRON" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITA DEGLI STUDI DI MILANO 

Organization address
address: Via Festa Del Perdono 7
city: MILANO
postcode: 20122
website: www.unimi.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-02-01   to  2023-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI MILANO IT (MILANO) coordinator 1˙500˙000.00

Map

 Project objective

'Given the alarming progression of chronic and relapsing infections in the last decades, and the even more alarming predictions for the upcoming years, it is urgent for chemists to be able to provide new molecular tools to study, and ultimately solve, these complex biological problems. Bacterial persisters are an elusive 'dormant' phenotype that play a pivotal role in chronic infections, with mechanisms that remain to be fully unravelled. Current knowledge suggests that bacterial persisters are not genetically resistant to antibiotic treatment; they simply appear to shut down through a cascade of biochemical events called the stringent response (SR), becoming insensitive to current drugs. This subpopulation remains unaffected during the time of pharmacological treatment and represents a reservoir that sustains pathogen survival and resurgence. The goal of this project is to fill the knowledge gap between persisters formation and infection eradication, providing the community with potent and selective small molecular tools that can be used to challenge complementary survival mechanisms. I will adopt a combined approach targeting a specific cellular trigger of the persister phenotype with small molecules designed ad hoc in order to switch it off. The target is a bacterial protein involved in the SR cascade, whose activity is proposed to be allosterically regulated. Coordination propensity analysis of the dynamic behaviour of the target will highlight regulation sites exploitable to modulate and control the protein activity. Structure-based design, virtual fragment screening and chemical synthesis will operate in synergy. Experimental screening methodologies intrinsically rich in structural information, such as those based on NMR spectroscopy, will be privileged. The overarching goal is to identify molecules able to prevent the insurgence of the 'dormant' drug-tolerant state and, possibly, revert the persisters already present to the 'awake' drug-sensitive phenotype.

'

 Publications

year authors and title journal last update
List of publications.
2019 Gabriele Conti, Marco Minneci, Sara Sattin
Optimised Synthesis of the Bacterial Magic Spot (p)ppGpp Chemosensor PyDPA
published pages: , ISSN: 1439-4227, DOI: 10.1002/cbic.201900013
ChemBioChem 2019-09-02

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The information about "ERACHRON" are provided by the European Opendata Portal: CORDIS opendata.

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