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ERACHRON SIGNED

Eradicating Chronic Infections

Total Cost €

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EC-Contrib. €

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Partnership

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 ERACHRON project word cloud

Explore the words cloud of the ERACHRON project. It provides you a very rough idea of what is the project "ERACHRON" about.

structure    dynamic    nmr    regulation    highlight    infection    experimental    simply    revert    events    intrinsically    protein    sites    fill    virtual    survival    unravelled    decades    drug    phenotype    prevent    regulated    community    alarming    screening    last    urgent    pharmacological    insensitive    combined    resurgence    tools    sustains    designed    synthesis    complementary    small    possibly    propensity    eradication    cascade    molecules    trigger    operate    pivotal    pathogen    biological    antibiotic    sensitive    sr    bacterial    fragment    stringent    genetically    infections    chemical    allosterically    dormant    predictions    reservoir    persister    structural    selective    resistant    relapsing    drugs    chemists    subpopulation    modulate    time    appear    molecular    treatment    spectroscopy    suggests    hoc    exploitable    chronic    switch    awake    gap    progression    insurgence    tolerant    persisters    off    biochemical    shut    play    privileged    ultimately    potent    overarching    mechanisms    upcoming    synergy    cellular    ad    unaffected    elusive   

Project "ERACHRON" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITA DEGLI STUDI DI MILANO 

Organization address
address: Via Festa Del Perdono 7
city: MILANO
postcode: 20122
website: www.unimi.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-02-01   to  2023-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI MILANO IT (MILANO) coordinator 1˙500˙000.00

Map

 Project objective

'Given the alarming progression of chronic and relapsing infections in the last decades, and the even more alarming predictions for the upcoming years, it is urgent for chemists to be able to provide new molecular tools to study, and ultimately solve, these complex biological problems. Bacterial persisters are an elusive 'dormant' phenotype that play a pivotal role in chronic infections, with mechanisms that remain to be fully unravelled. Current knowledge suggests that bacterial persisters are not genetically resistant to antibiotic treatment; they simply appear to shut down through a cascade of biochemical events called the stringent response (SR), becoming insensitive to current drugs. This subpopulation remains unaffected during the time of pharmacological treatment and represents a reservoir that sustains pathogen survival and resurgence. The goal of this project is to fill the knowledge gap between persisters formation and infection eradication, providing the community with potent and selective small molecular tools that can be used to challenge complementary survival mechanisms. I will adopt a combined approach targeting a specific cellular trigger of the persister phenotype with small molecules designed ad hoc in order to switch it off. The target is a bacterial protein involved in the SR cascade, whose activity is proposed to be allosterically regulated. Coordination propensity analysis of the dynamic behaviour of the target will highlight regulation sites exploitable to modulate and control the protein activity. Structure-based design, virtual fragment screening and chemical synthesis will operate in synergy. Experimental screening methodologies intrinsically rich in structural information, such as those based on NMR spectroscopy, will be privileged. The overarching goal is to identify molecules able to prevent the insurgence of the 'dormant' drug-tolerant state and, possibly, revert the persisters already present to the 'awake' drug-sensitive phenotype.

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 Publications

year authors and title journal last update
List of publications.
2019 Gabriele Conti, Marco Minneci, Sara Sattin
Optimised Synthesis of the Bacterial Magic Spot (p)ppGpp Chemosensor PyDPA
published pages: , ISSN: 1439-4227, DOI: 10.1002/cbic.201900013
ChemBioChem 2019-09-02

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The information about "ERACHRON" are provided by the European Opendata Portal: CORDIS opendata.

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