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SynapseER SIGNED

Endoplasmic reticulum structure and synaptic function in Drosophila

Total Cost €

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EC-Contrib. €

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Partnership

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 SynapseER project word cloud

Explore the words cloud of the SynapseER project. It provides you a very rough idea of what is the project "SynapseER" about.

sites    drosophila    tools    cellular    sponsor    characterization    electron    shows    wild    shaping    detect    axons    unknown    disrupt    roles    synapses    cells    structural    regulated    biology    fact    hsp    local    vertebrates    date    morphology    presynapses    model    patients    dendrites    light    motor    function    techniques    body    cell    organisation    contact    gene    opportune    examine    junctions    dysfunction    diseases    understand    terminals    endoplasmic    reduces    organelle    encoding    markers    human    neuromuscular    largely    nature    structures    proteins    network    neurodegenerative    3d    axonal    resolution    first    neuron    continuity    successfully    hereditary    physical    axon    super    reconstruction    ultrastructural    examined    disease    microscopy    mechanisms    encoded    time    impaired    altered    spastic    degeneration    termed    presynaptic    suggested    physiological    synaptic    mutants    reticulum    neuronal    paraplegia    functions    er    context    functional    genes    trafficking    mutations    neurons    data   

Project "SynapseER" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE 

Organization address
address: TRINITY LANE THE OLD SCHOOLS
city: CAMBRIDGE
postcode: CB2 1TN
website: www.cam.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-01-01   to  2020-05-01

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) coordinator 183˙454.00

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 Project objective

In neurons, endoplasmic reticulum (ER) organelle shows physical continuity between dendrites, cell body and axonal presynaptic terminals, and has been termed “a neuron within a neuron”. The importance of ER in axons is suggested by the fact that mutations of ER-shaping proteins result in hereditary spastic paraplegia (HSP), a motor axon degeneration disease. ER is present in presynapses, and mutations of ER-shaping proteins disrupt synaptic morphology or function. However, the physiological roles of ER distribution in this context are largely unknown.

The time to study the roles of ER distribution in presynaptic terminals is opportune: new HSP-associated genes encoding ER proteins are being identified continuously in human patients; studies in non-neuronal cells identified several HSP-gene-encoded proteins as ER-shaping proteins - to date these have not been examined in synapses; there is increasing data about the nature and roles of contact sites between ER and other cellular structures, whose functions are required at synapses. Drosophila is a successfully used model for neuronal cell biology and degeneration, which reduces use of regulated vertebrates; my sponsor has developed tools to detect impaired neuronal ER organisation in Drosophila; and emerging microscopy techniques allow ultrastructural analysis and 3D reconstruction of the ER network.

My work will specifically examine the distribution and role of ER at presynaptic level for the first time, and mechanisms of dysfunction that are relevant for human neurodegenerative diseases. I will study neuromuscular junctions in wild-type and in Drosophila mutants for HSP ER-shaping proteins, to understand the roles of these proteins and the consequences of any altered distribution for local trafficking and organelle function. To address this aim, I will use electron and super-resolution microscopy, and using light microscopy markers I will undertake structural and functional characterization of ER distribution.

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