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SynapseER SIGNED

Endoplasmic reticulum structure and synaptic function in Drosophila

Total Cost €

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EC-Contrib. €

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Partnership

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 SynapseER project word cloud

Explore the words cloud of the SynapseER project. It provides you a very rough idea of what is the project "SynapseER" about.

er    techniques    function    degeneration    dysfunction    date    mutations    microscopy    encoding    reconstruction    structures    suggested    network    regulated    super    neurodegenerative    reticulum    functions    data    mutants    unknown    context    synapses    human    encoded    detect    axons    proteins    model    axon    axonal    light    trafficking    continuity    examined    nature    organisation    presynaptic    presynapses    neuromuscular    opportune    hsp    characterization    neuronal    cellular    gene    motor    vertebrates    drosophila    endoplasmic    impaired    neuron    body    first    cell    resolution    ultrastructural    physical    successfully    morphology    terminals    local    diseases    paraplegia    spastic    electron    largely    fact    patients    neurons    sites    structural    tools    junctions    physiological    shaping    time    organelle    cells    hereditary    examine    sponsor    disrupt    roles    mechanisms    markers    3d    contact    altered    biology    dendrites    understand    functional    shows    genes    termed    reduces    wild    disease    synaptic   

Project "SynapseER" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE 

Organization address
address: TRINITY LANE THE OLD SCHOOLS
city: CAMBRIDGE
postcode: CB2 1TN
website: www.cam.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-01-01   to  2020-05-01

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) coordinator 183˙454.00

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 Project objective

In neurons, endoplasmic reticulum (ER) organelle shows physical continuity between dendrites, cell body and axonal presynaptic terminals, and has been termed “a neuron within a neuron”. The importance of ER in axons is suggested by the fact that mutations of ER-shaping proteins result in hereditary spastic paraplegia (HSP), a motor axon degeneration disease. ER is present in presynapses, and mutations of ER-shaping proteins disrupt synaptic morphology or function. However, the physiological roles of ER distribution in this context are largely unknown.

The time to study the roles of ER distribution in presynaptic terminals is opportune: new HSP-associated genes encoding ER proteins are being identified continuously in human patients; studies in non-neuronal cells identified several HSP-gene-encoded proteins as ER-shaping proteins - to date these have not been examined in synapses; there is increasing data about the nature and roles of contact sites between ER and other cellular structures, whose functions are required at synapses. Drosophila is a successfully used model for neuronal cell biology and degeneration, which reduces use of regulated vertebrates; my sponsor has developed tools to detect impaired neuronal ER organisation in Drosophila; and emerging microscopy techniques allow ultrastructural analysis and 3D reconstruction of the ER network.

My work will specifically examine the distribution and role of ER at presynaptic level for the first time, and mechanisms of dysfunction that are relevant for human neurodegenerative diseases. I will study neuromuscular junctions in wild-type and in Drosophila mutants for HSP ER-shaping proteins, to understand the roles of these proteins and the consequences of any altered distribution for local trafficking and organelle function. To address this aim, I will use electron and super-resolution microscopy, and using light microscopy markers I will undertake structural and functional characterization of ER distribution.

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The information about "SYNAPSEER" are provided by the European Opendata Portal: CORDIS opendata.

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