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SynapseER SIGNED

Endoplasmic reticulum structure and synaptic function in Drosophila

Total Cost €

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EC-Contrib. €

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Partnership

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 SynapseER project word cloud

Explore the words cloud of the SynapseER project. It provides you a very rough idea of what is the project "SynapseER" about.

opportune    encoding    3d    diseases    cell    impaired    human    unknown    reticulum    trafficking    genes    detect    presynapses    electron    understand    endoplasmic    hsp    hereditary    roles    wild    cells    regulated    functional    biology    disease    encoded    neurodegenerative    mechanisms    dendrites    resolution    continuity    axons    reduces    organelle    reconstruction    vertebrates    successfully    mutants    synapses    altered    examine    fact    presynaptic    gene    techniques    neuron    ultrastructural    sponsor    axonal    terminals    cellular    degeneration    axon    shows    patients    er    tools    suggested    junctions    organisation    neuronal    synaptic    dysfunction    drosophila    physiological    morphology    functions    nature    characterization    sites    proteins    examined    shaping    network    markers    body    contact    motor    date    structures    time    model    local    light    function    structural    mutations    super    spastic    physical    first    data    largely    termed    context    microscopy    neuromuscular    disrupt    neurons    paraplegia   

Project "SynapseER" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE 

Organization address
address: TRINITY LANE THE OLD SCHOOLS
city: CAMBRIDGE
postcode: CB2 1TN
website: www.cam.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-01-01   to  2020-05-01

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) coordinator 183˙454.00

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 Project objective

In neurons, endoplasmic reticulum (ER) organelle shows physical continuity between dendrites, cell body and axonal presynaptic terminals, and has been termed “a neuron within a neuron”. The importance of ER in axons is suggested by the fact that mutations of ER-shaping proteins result in hereditary spastic paraplegia (HSP), a motor axon degeneration disease. ER is present in presynapses, and mutations of ER-shaping proteins disrupt synaptic morphology or function. However, the physiological roles of ER distribution in this context are largely unknown.

The time to study the roles of ER distribution in presynaptic terminals is opportune: new HSP-associated genes encoding ER proteins are being identified continuously in human patients; studies in non-neuronal cells identified several HSP-gene-encoded proteins as ER-shaping proteins - to date these have not been examined in synapses; there is increasing data about the nature and roles of contact sites between ER and other cellular structures, whose functions are required at synapses. Drosophila is a successfully used model for neuronal cell biology and degeneration, which reduces use of regulated vertebrates; my sponsor has developed tools to detect impaired neuronal ER organisation in Drosophila; and emerging microscopy techniques allow ultrastructural analysis and 3D reconstruction of the ER network.

My work will specifically examine the distribution and role of ER at presynaptic level for the first time, and mechanisms of dysfunction that are relevant for human neurodegenerative diseases. I will study neuromuscular junctions in wild-type and in Drosophila mutants for HSP ER-shaping proteins, to understand the roles of these proteins and the consequences of any altered distribution for local trafficking and organelle function. To address this aim, I will use electron and super-resolution microscopy, and using light microscopy markers I will undertake structural and functional characterization of ER distribution.

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The information about "SYNAPSEER" are provided by the European Opendata Portal: CORDIS opendata.

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