Opendata, web and dolomites

SynapseER SIGNED

Endoplasmic reticulum structure and synaptic function in Drosophila

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 SynapseER project word cloud

Explore the words cloud of the SynapseER project. It provides you a very rough idea of what is the project "SynapseER" about.

body    resolution    patients    disrupt    microscopy    time    characterization    first    ultrastructural    shaping    light    largely    motor    physical    detect    markers    neurodegenerative    sponsor    reduces    encoded    date    physiological    human    presynaptic    axons    super    functions    morphology    impaired    terminals    spastic    neuronal    paraplegia    axonal    cellular    sites    altered    neuromuscular    nature    model    functional    disease    encoding    regulated    dysfunction    degeneration    tools    mutants    axon    organelle    roles    structural    shows    network    diseases    synapses    understand    continuity    data    drosophila    contact    examined    hsp    mechanisms    junctions    cells    fact    trafficking    termed    local    presynapses    neurons    synaptic    genes    er    hereditary    endoplasmic    cell    successfully    biology    opportune    unknown    reconstruction    gene    3d    reticulum    mutations    techniques    electron    vertebrates    suggested    neuron    organisation    examine    dendrites    context    wild    structures    proteins    function   

Project "SynapseER" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE 

Organization address
address: TRINITY LANE THE OLD SCHOOLS
city: CAMBRIDGE
postcode: CB2 1TN
website: www.cam.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-01-01   to  2020-05-01

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) coordinator 183˙454.00

Map

 Project objective

In neurons, endoplasmic reticulum (ER) organelle shows physical continuity between dendrites, cell body and axonal presynaptic terminals, and has been termed “a neuron within a neuron”. The importance of ER in axons is suggested by the fact that mutations of ER-shaping proteins result in hereditary spastic paraplegia (HSP), a motor axon degeneration disease. ER is present in presynapses, and mutations of ER-shaping proteins disrupt synaptic morphology or function. However, the physiological roles of ER distribution in this context are largely unknown.

The time to study the roles of ER distribution in presynaptic terminals is opportune: new HSP-associated genes encoding ER proteins are being identified continuously in human patients; studies in non-neuronal cells identified several HSP-gene-encoded proteins as ER-shaping proteins - to date these have not been examined in synapses; there is increasing data about the nature and roles of contact sites between ER and other cellular structures, whose functions are required at synapses. Drosophila is a successfully used model for neuronal cell biology and degeneration, which reduces use of regulated vertebrates; my sponsor has developed tools to detect impaired neuronal ER organisation in Drosophila; and emerging microscopy techniques allow ultrastructural analysis and 3D reconstruction of the ER network.

My work will specifically examine the distribution and role of ER at presynaptic level for the first time, and mechanisms of dysfunction that are relevant for human neurodegenerative diseases. I will study neuromuscular junctions in wild-type and in Drosophila mutants for HSP ER-shaping proteins, to understand the roles of these proteins and the consequences of any altered distribution for local trafficking and organelle function. To address this aim, I will use electron and super-resolution microscopy, and using light microscopy markers I will undertake structural and functional characterization of ER distribution.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "SYNAPSEER" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "SYNAPSEER" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

Widow Spider Mating (2020)

Immature mating as a novel tactic of an invasive widow spider

Read More  

GLORIOUS (2019)

Digital Poetry in Today’s Russia: Canonisation and Translation

Read More  

Kidney-Treg (2020)

Characterisation and impact of kidney-resident Tregs in kidney physiology and pathologies

Read More