LUPA

Unravelling the molecular basis of common complex human disorders using the dog as a model system

 Coordinatore UNIVERSITE DE LIEGE 

 Organization address city: LIEGE
postcode: 4000

contact info
Titolo: Dr.
Nome: Marilou Ramos
Cognome: Pamplona
Email: send email
Telefono: +32 4366 3702
Fax: +32 4366 4198

 Nazionalità Coordinatore Belgium [BE]
 Sito del progetto http://www.eurolupa.org/
 Totale costo 15˙677˙376 €
 EC contributo 11˙997˙994 €
 Programma FP7-HEALTH
Specific Programme "Cooperation": Health
 Code Call FP7-HEALTH-2007-A
 Funding Scheme CP-IP
 Anno di inizio 2008
 Periodo (anno-mese-giorno) 2008-01-01   -   2012-06-30

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    UNIVERSITE DE LIEGE

 Organization address city: LIEGE
postcode: 4000

contact info
Titolo: Dr.
Nome: Marilou Ramos
Cognome: Pamplona
Email: send email
Telefono: +32 4366 3702
Fax: +32 4366 4198

BE (LIEGE) coordinator 0.00
2    ANIMAL HEALTH TRUST

 Organization address address: "Lanwades Hall, Lanwades Park"
city: "Kentford, Newmarket"
postcode: CB8 7UU

contact info
Titolo: Dr.
Nome: Caroline
Cognome: Reynolds
Email: send email
Telefono: +44 8700 502424
Fax: +44 8700 502425

UK ("Kentford, Newmarket") participant 0.00
3    ANTAGENE

 Organization address address: "ALLEE DES SEQUOIAS 2, IMMEUBLE LE MELTEM"
city: LIMONEST
postcode: 69760

contact info
Titolo: Dr.
Nome: Guillaume
Cognome: Queney
Email: send email
Telefono: +33 4 37 49 90 03
Fax: +33 4 37 49 04 89

FR (LIMONEST) participant 0.00
4    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

 Organization address address: Rue Michel -Ange 3
city: PARIS
postcode: 75794

contact info
Titolo: Ms.
Nome: Florence
Cognome: Morineau
Email: send email
Telefono: +33 2 99 28 68 15
Fax: +33 2 99 28 68 03

FR (PARIS) participant 0.00
5    COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

 Organization address address: RUE LEBLANC 25
city: PARIS 15
postcode: 75015

contact info
Titolo: Ms.
Nome: Elizabeth
Cognome: May
Email: send email
Telefono: +33 1 6087 8404
Fax: +33 1 60 7 8484

FR (PARIS 15) participant 0.00
6    ECOLE NATIONALE VETERINAIRE D'ALFORT

 Organization address address: Avenue du General de Gaulle 7
city: MAISONS-ALFORT
postcode: 94704

contact info
Titolo: Mr.
Nome: Bernard
Cognome: Gauthier
Email: send email
Telefono: +33 1 43967010
Fax: +33 1 43967099

FR (MAISONS-ALFORT) participant 0.00
7    HELSINGIN YLIOPISTO

 Organization address address: YLIOPISTONKATU 4
city: HELSINGIN YLIOPISTO
postcode: 14

contact info
Titolo: Ms.
Nome: Katariina
Cognome: Vainio-Mattila
Email: send email
Telefono: +358 9 191 25043
Fax: +358 9 191 25044

FI (HELSINGIN YLIOPISTO) participant 0.00
8 KOBENHAVNS UNIVERSITET DK participant 0.00
9    LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN

 Organization address address: GESCHWISTER SCHOLL PLATZ 1
city: MUENCHEN
postcode: 80539

contact info
Titolo: Prof.
Nome: Kartin
Cognome: Hartmann
Email: send email
Telefono: +49 89 21802651
Fax: +49 89 218016501

DE (MUENCHEN) participant 0.00
10    NORGES MILJO-OG BIOVITENSKAPLIGE UNIVERSITET

 Organization address address: UNIVERSITETSTUNET 3
city: AS
postcode: 1430

contact info
Titolo: Prof
Nome: Knut
Cognome: Børve
Email: send email
Telefono: +47 22964502
Fax: +47 22597015

NO (AS) participant 0.00
11    NORGES VETERINAERHOGSKOLE

 Organization address address: Ullevaalsveien 72
city: OSLO
postcode: 33

contact info
Titolo: Prof
Nome: Knut
Cognome: Børve
Email: send email
Telefono: +47 22964502
Fax: +47 22597015

NO (OSLO) participant 0.00
12    SVERIGES LANTBRUKSUNIVERSITET

 Organization address address: ARRHENIUSPLAN 4
city: UPPSALA
postcode: 75007

contact info
Titolo: Ms.
Nome: Ingrid
Cognome: Ragnarsdotter Jajke
Email: send email
Telefono: +46 18 671437
Fax: +46 18 6735 34

SE (UPPSALA) participant 0.00
13    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE

 Organization address address: The Old Schools, Trinity Lane
city: CAMBRIDGE
postcode: CB2 1TN

contact info
Titolo: Ms.
Nome: Dawn
Cognome: Barker
Email: send email
Telefono: +44 1223 333543
Fax: +44 1223 332988

UK (CAMBRIDGE) participant 0.00
14    THE ROYAL VETERINARY COLLEGE

 Organization address address: Royal College Street
city: LONDON
postcode: NW10TU

contact info
Titolo: Mr.
Nome: Turhan
Cognome: Alasya
Email: send email
Telefono: +44 2074 685208
Fax: +44 2073 881027

UK (LONDON) participant 0.00
15    THE UNIVERSITY OF LIVERPOOL

 Organization address address: Brownlow Hill, Foundation Building 765
city: LIVERPOOL
postcode: L69 7ZX

contact info
Titolo: Mr.
Nome: Colin
Cognome: Cooper
Email: send email
Telefono: +44 151 794 8722
Fax: +44 151 794 8728

UK (LIVERPOOL) participant 0.00
16    THE UNIVERSITY OF MANCHESTER

 Organization address address: OXFORD ROAD
city: MANCHESTER
postcode: M13 9PL

contact info
Titolo: Ms.
Nome: Liz
Cognome: Fay
Email: send email
Telefono: +44 161 275 7114
Fax: 441613000000

UK (MANCHESTER) participant 0.00
17    THE UNIVERSITY OF NOTTINGHAM

 Organization address address: University Park
city: NOTTINGHAM
postcode: NG7 2RD

contact info
Titolo: Mr.
Nome: Paul
Cognome: Cartledge
Email: send email
Telefono: +44 115 951 5679
Fax: +44 115 951 3633

UK (NOTTINGHAM) participant 0.00
18    UNIVERSITAET BERN

 Organization address address: Hochschulstrasse 4
city: BERN
postcode: 3012

contact info
Titolo: Prof.
Nome: Tosso
Cognome: Leeb
Email: send email
Telefono: +41 31 631 2326
Fax: +41 31 631 2640

CH (BERN) participant 0.00
19    UNIVERSITAET ZUERICH

 Organization address address: Raemistrasse 71
city: ZURICH
postcode: 8006

contact info
Titolo: Ms.
Nome: Martha
Cognome: Sekey
Email: send email
Telefono: +41 44 635 81 11
Fax: +41 44 635 89 30

CH (ZURICH) participant 0.00
20    UNIVERSITAT AUTONOMA DE BARCELONA

 Organization address address: Campus UAB -BELLATERRA- s/n
city: CERDANYOLA DEL VALLES
postcode: 8193

contact info
Titolo: Ms.
Nome: Katja
Cognome: Shustakowitz
Email: send email
Telefono: +34 935812940
Fax: +34 935812023

ES (CERDANYOLA DEL VALLES) participant 0.00
21    UNIVERSITEIT UTRECHT

 Organization address address: Heidelberglaan 8
city: UTRECHT
postcode: 3584 CS

contact info
Titolo: Mr.
Nome: Marcel
Cognome: Jansen
Email: send email
Telefono: +31 302531703
Fax: +31 302518126

NL (UTRECHT) participant 0.00
22    UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN

 Organization address address: BELFIELD
city: DUBLIN
postcode: 4

contact info
Titolo: Mr.
Nome: Donal
Cognome: Doolan
Email: send email
Telefono: +353 1 7161656
Fax: +353 1 7161216

IE (DUBLIN) participant 0.00
23    UPPSALA UNIVERSITET

 Organization address address: SANKT OLOFSGATAN 10 B
city: UPPSALA
postcode: 751 05

contact info
Titolo: Ms.
Nome: Marianne
Cognome: Wigenius
Email: send email
Telefono: +46 18 471 4389
Fax: +46 18 471 4673

SE (UPPSALA) participant 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

cardiovascular    suffer    molecular    scans    cancer    diseases    genomics    humans    association    gene    illnesses    genome    dog    model    veterinary    snp    neurological    genes    lupa    genetic    cancers    breeds    dogs    disorders    collect    complexity    human    genetics    collected    samples    mapping    monogenic    clinics    dna    insights    inflammatory    countries    drift    cohorts    studying    purebred   

 Obiettivo del progetto (Objective)

'Despite major efforts, identifying susceptibility genes for common human diseases - cancer, cardiovascular, inflammatory and neurological disorders - is difficult due to the complexity of the underlying causes. The dog population is composed of ~ 400 purebred breeds; each one is a genetic isolate with unique characteristics resulting from persistent selection for desired attributes or from genetic drift / inbreeding. Dogs tend to suffer from the same range of diseases than human but the genetic complexity of these diseases within a breed is reduced as a consequence of the genetic drift and – due to long-range linkage disequilibrium – the number of SNP markers needed to perform whole genome scans is divided by at least ten. Here, we propose a European effort gathering experts in genomics to take advantage of this extraordinary genetic model. Veterinary clinics from 12 European countries will collect DNA samples from large cohorts of dogs suffering from a range of thoroughly defined diseases of relevance to human health. Once these different cohorts will be built, DNA samples will be sent to a centralized, high-throughput SNP genotyping facility. The SNP genotypes will be stored in central database and made available to participating collaborating centres, who will analyze the data with the support of dedicated statistical genetics platforms. Following genome wide association and fine-mapping candidate genes will be followed up at the molecular level by expert animal and human genomics centers. This innovative approach using the dog model will ultimately provide insights into the pathogenesis of common human diseases – its primary goal.'

Introduzione (Teaser)

Identifying genetic information on illnesses in dogs may help find cures for serious illnesses such as cancer, as well as cardiovascular, inflammatory and neurological disorders.

Descrizione progetto (Article)

Studying common human diseases such as cancer or cardiovascular disorders from a genetic perspective can yield much-needed information about how to properly diagnose and treat them. A particular field in genetics - called genomics - focuses on mapping or 'sequencing' the genes or DNA implicated in these diseases. Because the human genome is quite complicated, it is often easier and quicker to study the genome of dogs, who also suffer from similar diseases. Man's best friend is generally less complex genetically than humans, and less samples are needed to derive meaningful information.

The LUPA project is unravelling the molecular basis of common human disorders using the dog as a model system. It is studying genetic factors both in purebred dogs and in mixed breeds for more efficient localisation of key genetic factors.

The main goal of LUPA is to identify genes and mutations that account for the high incidence of certain diseases in specific dog breeds. The culprit genes are identified by looking at the entire gene mapping sequence of dogs - or their genome - using what's known as genome-wide association studies (GWAS). Genetic material is being identified for five different categories of illnesses: cancers, cardiovascular disorders, inflammatory disorders, neurological disorders and monogenic disorders (those caused by a mutation in a single gene). Altogether, the LUPA project is performing genome-wide scans on over 10,000 dogs.

There are 20 veterinary clinics in 12 European countries working together to collect DNA samples required for the different project partners. Collection and characterisation of samples is a formidable task and has taken over two years. Almost all samples have been collected, with the involvement of kennels, breeders, veterinarians and owners.

Overall, since the project kicked off more than 7,000 samples have been collected and processed. Promising results are already emerging for two monogenic diseases, and similar genes in humans have been identified. Moreover, genome areas in dogs have been identified for other more complex disorders such as epilepsy, cancers, cardiovascular diseases and inflammatory disorders.

In addition to providing new insights regarding prognosis and treatment of human diseases, LUPA could have a major impact on the future of veterinary medicine in Europe.

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