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DRIVE SIGNED

GUIDANCE AND FUNCTION OF REGENERATIVE FIBERS IN ADULT CNS

Total Cost €

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EC-Contrib. €

0

Partnership

0

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 DRIVE project word cloud

Explore the words cloud of the DRIVE project. It provides you a very rough idea of what is the project "DRIVE" about.

exceptional    jak    cns    central    repair    circuit    innovative    neurons    regenerate    misguidance    mechanisms    shown    aberrant    adult    demonstrated    cues    adults    visual    neurodegenerative    functions    trauma    previously    projections    unexplored    properly    nervous    levels    neurobiology    injury    society    critical    functional    axon    imaging    ex    brain    therapeutic    fundamental    understand    biochemistry    regenerative    novo    mature    extrinsic    developmental    circuits    possibility    generate    phenomenon    unlike    combination    axons    simultaneous    questions    regenerating    mechanism    altogether    exacerbates    drive    irreversible    guidance    close    answer    fail    formed    intrinsic    analyze    impairment    greatest    diseases    ways    explore    responsive    model    vital    activation    opens    form    myc    uncovered    spectrum    nerve    young    connections    modalities    optic    electrophysiology    stat    manipulating    expressed    axonal    vivo    breakthroughs    regeneration    leads    mtor    de   

Project "DRIVE" data sheet

The following table provides information about the project.

Coordinator
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 

Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654
website: www.inserm.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙499˙410 €
 EC max contribution 1˙499˙410 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-03-01   to  2023-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) coordinator 1˙499˙410.00

Map

 Project objective

The impairment of central nervous system (CNS) leads to irreversible loss of vital functions because, unlike young neurons, mature neurons are not able to regenerate. Thus, understanding the detailed mechanisms of axonal growth and repair remains one of the greatest challenges of neurobiology and for society. If the extrinsic factors fail to reach levels required for regeneration, manipulating intrinsic pathways has shown promising results. Particularly, my work demonstrated that the simultaneous activation of mTOR, JAK/STAT and c-myc pathways allows exceptional regeneration with axons close to their targets. However it also exacerbates previously described phenomenon of misguidance with potential aberrant circuit formation. My unique model opens up the possibility to explore these fundamental questions of CNS regeneration. I propose to address the yet unexplored problem of the guidance of regenerating axons in adults in order to promote the formation of a functional new circuit after injury. Indeed what are the modalities of guidance in the adult? Are axons still responsive to developmental guidance cues and are they still expressed? Can regenerative axons form connections with their targets and are these connections functional? To answer these critical questions, I will use the combination of state of the art biochemistry, imaging, and electrophysiology in an in-vivo and ex-vivo model of the visual system to 1) Understand axon guidance in mature system in order to properly drive regenerative axons to their brain targets and avoid aberrant projections, and 2) Analyze the formation of a functional optic nerve circuit after injury. Altogether, these results will generate major breakthroughs in a fundamental but uncovered mechanism of axon guidance during regeneration and the functionality of de novo formed circuits. They will open up new ways for innovative therapeutic development after CNS trauma but also to the large spectrum of neurodegenerative diseases.

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The information about "DRIVE" are provided by the European Opendata Portal: CORDIS opendata.

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