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SynarchiC SIGNED

Investigating the functional architecture of microbial genomes with synthetic approaches

Total Cost €

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EC-Contrib. €

0

Partnership

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 SynarchiC project word cloud

Explore the words cloud of the SynarchiC project. It provides you a very rough idea of what is the project "SynarchiC" about.

scientists    multiple    intermingled    insights    patterns    interacts    stressful    capture    track    fundamental    consists    metabolism    3d    innovative    molecular    difficult    functional    infectious    structures    maintenance    functionally    unable    chromosomes    disambiguating    synarchic    smc    entire    topological    combined    dynamic    reverse    folded    redirects    duplicated    metabolic    ranging    technologies    players    ing    molecules    segregation    limiting    sister    yeast    hosts    appeal    individualization    genomes    uncovered    scs    organization    interplay    evolutionary    broadly    intertwined    proteins    prokaryotic    cell    sc    conformation    pathogen    assortment    actively    expression    bacteria    mitosis    derivatives    gene    environment    contacts    host    synthetic    characterization    layers    limited    networks    eukaryotic    engineering    structural    folding    genome    conserved    chromatids    microbial    perspective    chromosome    replication    involve    regulates    cycle    phylum    discriminate    clade   

Project "SynarchiC" data sheet

The following table provides information about the project.

Coordinator
INSTITUT PASTEUR 

Organization address
address: RUE DU DOCTEUR ROUX 25-28
city: PARIS CEDEX 15
postcode: 75724
website: http://www.pasteur.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙995˙557 €
 EC max contribution 1˙995˙557 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-04-01   to  2023-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT PASTEUR FR (PARIS CEDEX 15) coordinator 1˙995˙557.00

Map

 Project objective

The folding of eukaryotic and prokaryotic chromosomes consists of an assortment of intertwined structural features. The resulting complex networks of contacts is highly dynamic and interacts functionally with, or regulates metabolic processes ranging from gene expression to chromosome segregation. Some higher order structures involve evolutionary conserved molecular players, such as structural maintenance of chromosomes (SMC) proteins, while others depend on phylum specific proteins. The functional organization of yeast and bacteria chromosomes are actively investigated, with multiple folded structures uncovered in recent years. However, disambiguating the intermingled structures is a difficult task, limiting their functional characterization. In addition, current technologies are limited and are unable to track the genome-wide folding of duplicated sister chromatids (SC) molecules, limiting the study of genome folding during replication and mitosis.

The overall aim of the SynarchiC project is to characterize, through innovative derivatives of the chromosome conformation capture technology combined with synthetic chromosomes, the folding patterns of microbial genomes during the entire cell cycle, including those of SCs. By reverse engineering chromosomes in bacteria and yeast, we will discriminate the different layers of topological structures and their associated molecular players. We will then investigate how these 3D structures affect SC folding, individualization, and segregation. Finally, we will investigate the interplay between a pathogen and its hosts during an infectious process. How the bacteria redirects its host chromosome metabolism in stressful environment will be addressed from the perspective of genome organization and segregation. Technologies and results from SynarchiC will provide fundamental insights on the cell cycle, and should appeal broadly to scientists working on various aspects genome functional organization in any clade.

 Publications

year authors and title journal last update
List of publications.
2018 Héloïse Muller, Vittore F Scolari, Nicolas Agier, Aurèle Piazza, Agnès Thierry, Guillaume Mercy, Stéphane Descorps‐Declere, Luciana Lazar‐Stefanita, Olivier Espeli, Bertrand Llorente, Gilles Fischer, Julien Mozziconacci, Romain Koszul
Characterizing meiotic chromosomes\' structure and pairing using a designer sequence optimized for Hi‐C
published pages: , ISSN: 1744-4292, DOI: 10.15252/msb.20188293
Molecular Systems Biology 14/7 2019-12-17

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