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SynarchiC SIGNED

Investigating the functional architecture of microbial genomes with synthetic approaches

Total Cost €

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EC-Contrib. €

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Partnership

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 SynarchiC project word cloud

Explore the words cloud of the SynarchiC project. It provides you a very rough idea of what is the project "SynarchiC" about.

structural    limiting    difficult    organization    cell    segregation    bacteria    derivatives    uncovered    functionally    disambiguating    engineering    synthetic    individualization    redirects    yeast    sister    combined    reverse    multiple    track    folding    duplicated    patterns    prokaryotic    stressful    conserved    perspective    discriminate    technologies    infectious    limited    metabolism    sc    innovative    unable    interacts    molecules    environment    folded    scs    fundamental    metabolic    actively    expression    contacts    synarchic    chromatids    topological    interplay    ranging    chromosomes    layers    consists    players    hosts    genome    insights    intertwined    entire    pathogen    maintenance    genomes    dynamic    capture    smc    molecular    chromosome    conformation    3d    characterization    involve    clade    evolutionary    replication    microbial    assortment    regulates    gene    structures    scientists    ing    cycle    proteins    broadly    mitosis    appeal    functional    intermingled    host    eukaryotic    phylum    networks   

Project "SynarchiC" data sheet

The following table provides information about the project.

Coordinator		 INSTITUT PASTEUR 

Organization address
address: RUE DU DOCTEUR ROUX 25-28
city: PARIS CEDEX 15
postcode: 75724
website: http://www.pasteur.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country France [FR]
 Total cost 1˙995˙557 €
 EC max contribution 1˙995˙557 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-04-01   to  2023-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT PASTEUR FR (PARIS CEDEX 15) coordinator 1˙995˙557.00

Map

 Project objective

The folding of eukaryotic and prokaryotic chromosomes consists of an assortment of intertwined structural features. The resulting complex networks of contacts is highly dynamic and interacts functionally with, or regulates metabolic processes ranging from gene expression to chromosome segregation. Some higher order structures involve evolutionary conserved molecular players, such as structural maintenance of chromosomes (SMC) proteins, while others depend on phylum specific proteins. The functional organization of yeast and bacteria chromosomes are actively investigated, with multiple folded structures uncovered in recent years. However, disambiguating the intermingled structures is a difficult task, limiting their functional characterization. In addition, current technologies are limited and are unable to track the genome-wide folding of duplicated sister chromatids (SC) molecules, limiting the study of genome folding during replication and mitosis.

The overall aim of the SynarchiC project is to characterize, through innovative derivatives of the chromosome conformation capture technology combined with synthetic chromosomes, the folding patterns of microbial genomes during the entire cell cycle, including those of SCs. By reverse engineering chromosomes in bacteria and yeast, we will discriminate the different layers of topological structures and their associated molecular players. We will then investigate how these 3D structures affect SC folding, individualization, and segregation. Finally, we will investigate the interplay between a pathogen and its hosts during an infectious process. How the bacteria redirects its host chromosome metabolism in stressful environment will be addressed from the perspective of genome organization and segregation. Technologies and results from SynarchiC will provide fundamental insights on the cell cycle, and should appeal broadly to scientists working on various aspects genome functional organization in any clade.

 Publications

year authors and title journal last update
List of publications.
2018 Héloïse Muller, Vittore F Scolari, Nicolas Agier, Aurèle Piazza, Agnès Thierry, Guillaume Mercy, Stéphane Descorps‐Declere, Luciana Lazar‐Stefanita, Olivier Espeli, Bertrand Llorente, Gilles Fischer, Julien Mozziconacci, Romain Koszul
Characterizing meiotic chromosomes\' structure and pairing using a designer sequence optimized for Hi‐C
published pages: , ISSN: 1744-4292, DOI: 10.15252/msb.20188293 		Molecular Systems Biology 14/7 2019-12-17

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