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CLAUSTRUM SIGNED

The Claustrum: A Circuit Hub for Attention

Total Cost €

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EC-Contrib. €

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Partnership

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 CLAUSTRUM project word cloud

Explore the words cloud of the CLAUSTRUM project. It provides you a very rough idea of what is the project "CLAUSTRUM" about.

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Project "CLAUSTRUM" data sheet

The following table provides information about the project.

Coordinator
THE HEBREW UNIVERSITY OF JERUSALEM 

Organization address
address: EDMOND J SAFRA CAMPUS GIVAT RAM
city: JERUSALEM
postcode: 91904
website: www.huji.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 1˙995˙000 €
 EC max contribution 1˙995˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-03-01   to  2023-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE HEBREW UNIVERSITY OF JERUSALEM IL (JERUSALEM) coordinator 1˙995˙000.00

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 Project objective

Our senses face a constant barrage of information. Hence, understanding how our brain enables us to attend to relevant stimuli, while ignoring distractions, is of increasing biomedical importance. Recently, I discovered that the claustrum, a multi-sensory hub and recipient of extensive neuromodulatory input, enables resilience to distraction.

In my ERC project, I will explore the mechanisms underlying claustral mediation of resilience to distraction and develop novel approaches for assessing and modulating attention in mice, with implications for humans. Transgenic mouse models that I identified as enabling selective access to claustral neurons overcome its limiting anatomy, making the claustrum accessible to functional investigation. Using this novel genetic access, I obtained preliminary results strongly suggesting that the claustrum functions to filter distractions by adjusting cortical sensory gain.

My specific aims are: 1) To delineate the mechanisms whereby the claustrum achieves sensory gain control, by applying in-vivo cell-attached, multi-unit and fiber photometry recordings from claustral and cortical neurons during attention-demanding tasks. 2) To discriminate between the functions of the claustrum in multi-sensory integration and implementation of attention strategies, by employing multi-sensory behavioral paradigms while modulating claustral function. 3) To develop validated complementary physiological and behavioral protocols for adjusting claustral mediation of attention via neuromodulation.

This study is unique in its focus and aims: it will provide a stringent neurophysiological framework for defining a key mechanism underlying cognitive concepts of attention, and establish a novel platform for studying the function of the claustrum and manipulating its activity. The project is designed to achieve breakthroughs of fundamental nature and potentially lead to diagnostic and therapeutic advances relevant to attention disorders.

 Publications

year authors and title journal last update
List of publications.
2019 David M. Lipton, Ben J. Gonzales, Ami Citri
Dorsal Striatal Circuits for Habits, Compulsions and Addictions
published pages: , ISSN: 1662-5137, DOI: 10.3389/fnsys.2019.00028
Frontiers in Systems Neuroscience 13 2020-02-05
2018 Gal Atlan, Anna Terem, Noa Peretz-Rivlin, Kamini Sehrawat, Ben Jerry Gonzales, Guy Pozner, Gen-ichi Tasaka, Yael Goll, Ron Refaeli, Ori Zviran, Byung Kook Lim, Maya Groysman, Inbal Goshen, Adi Mizrahi, Israel Nelken, Ami Citri
The Claustrum Supports Resilience to Distraction
published pages: 2752-2762.e7, ISSN: 0960-9822, DOI: 10.1016/j.cub.2018.06.068
Current Biology 28/17 2020-02-05
2019 Ben Jerry Gonzales, Diptendu Mukherjee, Reut Ashwal-Fluss, Yonatan Loewenstein, Ami Citri
Subregion-specific rules govern the distribution of neuronal immediate-early gene induction
published pages: 201913658, ISSN: 0027-8424, DOI: 10.1073/pnas.1913658116
Proceedings of the National Academy of Sciences 2020-02-05

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