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nanoAXON SIGNED

Nano-physiology of small glutamatergic axon terminals

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 nanoAXON project word cloud

Explore the words cloud of the nanoAXON project. It provides you a very rough idea of what is the project "nanoAXON" about.

gyrus    mechanistic    dentate    matches    supramammillary    impacts    originate    mossy    circuits    region    single    physiologically    clamp    axons    cell    hypothalamic    recordings    neurons    place    patterns    nucleus    recorded    memory    glutamatergic    cortical    anatomically    regions    insights    recording    places    synapses    contributes    mechanisms    understand    hilar    exceptional    voltage    neuronal    principles    translated    functions    simulations    entorhinal    unprecedented    revealing    individual    axon    basic    fundamental    synaptic    axonal    physiological    discoveries    cns    direct    spike    upstream    imaging    primary    afferent    details    generate    projections    small    computational    convey    representation    universal    reveal    successful    questions    advantaged    transfers    patch    hippocampal    efferent    calcium    repertoire    cortex    position    spatial    ultimately    cells    signaling    biophysical    size    majority    intrinsic    terminals    attainable    unitary   

Project "nanoAXON" data sheet

The following table provides information about the project.

Coordinator
INSTITUTE OF EXPERIMENTAL MEDICINE - HUNGARIAN ACADEMY OF SCIENCES 

Organization address
address: Szigony utca 43
city: Budapest
postcode: 1083
website: www.koki.hu

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Hungary [HU]
 Total cost 1˙994˙025 €
 EC max contribution 1˙994˙025 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-04-01   to  2023-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUTE OF EXPERIMENTAL MEDICINE - HUNGARIAN ACADEMY OF SCIENCES HU (Budapest) coordinator 1˙994˙025.00

Map

 Project objective

We will reveal the neuronal mechanisms of fundamental hippocampal and axonal functions using direct patch clamp recordings from the small axon terminals of the major glutamatergic afferent and efferent pathways of the dentate gyrus region. Specifically, we will investigate the intrinsic axonal properties and unitary synaptic functions of the axons in the dentate gyrus that originate from the entorhinal cortex, the hilar mossy cells and the hypothalamic supramammillary nucleus. The fully controlled access to the activity of individual neuronal projections allows us to address the crucial questions how upstream regions of the dentate gyrus convey physiologically relevant spike activities and how these activities are translated to unitary synaptic responses in individual dentate gyrus neurons. The successful information transfers by these mechanisms ultimately generate specific dentate gyrus cell activity that contributes to hippocampal memory functions. Comprehensive mechanistic insights are essential to understand the impacts of the activity patterns associated with fundamental physiological functions and attainable with the necessary details only with direct recordings from individual axons. For example, these knowledge are necessary to understand how single cell activities in the entorhinal cortex (carrying primary spatial information) contribute to spatial representation in the dentate (i.e. place fields). Furthermore, because the size of these recorded axon terminals matches that of the majority of cortical synapses, our discoveries will demonstrate basic biophysical and neuronal principles of axonal signaling that are relevant for universal neuronal functions throughout the CNS. Thus, an exceptional repertoire of methods, including recording from anatomically identified individual small axon terminals, voltage- and calcium imaging and computational simulations, places us in an advantaged position for revealing unprecedented information about neuronal circuits.

 Deliverables

List of deliverables.
Data Management Plan Open Research Data Pilot 2019-11-14 10:11:28

Take a look to the deliverables list in detail:  detailed list of nanoAXON deliverables.

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The information about "NANOAXON" are provided by the European Opendata Portal: CORDIS opendata.

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