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WISDOM SIGNED

The autonomous floral pathway: a WIndow to Study the tight link between non-coDing RNA and chrOMatin regulation

Total Cost €

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EC-Contrib. €

0

Partnership

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 WISDOM project word cloud

Explore the words cloud of the WISDOM project. It provides you a very rough idea of what is the project "WISDOM" about.

output    interconnections    central    arabidopsis    locus    skills    expression    competences    transcript    generally    rna    academic    stable    specificity    repression    reproductive    international    substantial    my    repressor    collaborative    strategy    base    sense    biochemistry    plays    plant    methylate    capitalize    proteomic    histone    unknown    histones    controls    suggests    lab    missing    molecular    goals    fy    regulation    nature    host    me    proteins    triggered    hypothesis    building    transcriptional    represses    contact    fld    demethylase    contributes    genetics    gained    conserved    polyadenylation    protein    fellowship    sdg26    mediated    networks    environment    flc    creative    myself    co    alternative    proximal    coding    skillset    eukaryotes    mobility    elusive    floral    splicing    experimental    components    antisense    delivers    identification    drive    regulate    link    quantitative    domain    transferable    biology    fca    genome    mechanistic    mechanism    career    transcription    interconnection    action    engagement    chromatin    public    h3k4    training    silencing    explore    coolair    deeper   

Project "WISDOM" data sheet

The following table provides information about the project.

Coordinator
JOHN INNES CENTRE 

Organization address
address: NORWICH RESEARCH PARK COLNEY
city: NORWICH
postcode: NR4 7UH
website: www.jic.bbsrc.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-04-01   to  2020-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    JOHN INNES CENTRE UK (NORWICH) coordinator 195˙454.00

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 Project objective

My Fellowship will explore the interconnection between non-coding RNA and chromatin regulation. Building on a detailed mechanistic base, I will capitalize on the recent proteomic identification of a stable complex FLD/SDG26 by my host lab, which plays a central role in the co-transcriptional silencing of the Arabidopsis floral repressor locus FLC. This protein complex is central to a mechanism determining the quantitative expression level of FLC, and thus the reproductive strategy of the plant. However, these activities also regulate many other targets in the Arabidopsis genome and the conserved nature of the components suggests the deeper understanding gained from this study will be important generally across all eukaryotes. FLD is a histone demethylase with specificity for H3K4; SDG26 is a SET domain protein likely to methylate histones and other proteins, but whose specificity is currently unknown. The splicing and alternative processing of FLC antisense non-coding transcript, COOLAIR, is essential for the repression of FLC transcription. However, how the processing of COOLAIR controls sense transcription remains elusive. My proposal aims to: 1) test the hypothesis that the FLD/SDG26 complex, triggered by FCA/FY-mediated proximal polyadenylation of COOLAIR, delivers a specific chromatin environment, which represses transcriptional output: and 2) explore the missing link between FCA/FY-mediated proximal polyadenylation of COOLAIR and chromatin regulation by FLD/SDG26 complex. My proposal involves interconnections between genetics, biochemistry and molecular biology, enabling me to develop a broader experimental skillset. It directly contributes to the action’s goals to: improve my creative potential and competences through international mobility and advanced training in technical and transferable skills; enhance collaborative and contact networks for both myself and my host lab through academic and public engagement; and drive substantial career development.

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