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WISDOM SIGNED

The autonomous floral pathway: a WIndow to Study the tight link between non-coDing RNA and chrOMatin regulation

Total Cost €

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EC-Contrib. €

0

Partnership

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 WISDOM project word cloud

Explore the words cloud of the WISDOM project. It provides you a very rough idea of what is the project "WISDOM" about.

me    building    output    transcription    protein    splicing    quantitative    stable    rna    regulate    coding    unknown    biology    alternative    eukaryotes    engagement    components    my    genome    missing    plays    fy    substantial    triggered    h3k4    proximal    explore    silencing    identification    deeper    myself    central    lab    contributes    hypothesis    sdg26    sense    mobility    generally    repression    mediated    training    public    expression    gained    histones    interconnection    molecular    controls    transferable    methylate    genetics    regulation    proteins    fellowship    biochemistry    nature    polyadenylation    environment    locus    transcriptional    base    action    antisense    mechanism    drive    demethylase    collaborative    fca    domain    link    histone    proteomic    coolair    chromatin    interconnections    suggests    skills    host    represses    reproductive    transcript    arabidopsis    mechanistic    delivers    co    flc    strategy    academic    skillset    fld    repressor    plant    conserved    specificity    career    elusive    international    creative    floral    networks    experimental    capitalize    competences    goals    contact   

Project "WISDOM" data sheet

The following table provides information about the project.

Coordinator
JOHN INNES CENTRE 

Organization address
address: NORWICH RESEARCH PARK COLNEY
city: NORWICH
postcode: NR4 7UH
website: www.jic.bbsrc.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-04-01   to  2020-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    JOHN INNES CENTRE UK (NORWICH) coordinator 195˙454.00

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 Project objective

My Fellowship will explore the interconnection between non-coding RNA and chromatin regulation. Building on a detailed mechanistic base, I will capitalize on the recent proteomic identification of a stable complex FLD/SDG26 by my host lab, which plays a central role in the co-transcriptional silencing of the Arabidopsis floral repressor locus FLC. This protein complex is central to a mechanism determining the quantitative expression level of FLC, and thus the reproductive strategy of the plant. However, these activities also regulate many other targets in the Arabidopsis genome and the conserved nature of the components suggests the deeper understanding gained from this study will be important generally across all eukaryotes. FLD is a histone demethylase with specificity for H3K4; SDG26 is a SET domain protein likely to methylate histones and other proteins, but whose specificity is currently unknown. The splicing and alternative processing of FLC antisense non-coding transcript, COOLAIR, is essential for the repression of FLC transcription. However, how the processing of COOLAIR controls sense transcription remains elusive. My proposal aims to: 1) test the hypothesis that the FLD/SDG26 complex, triggered by FCA/FY-mediated proximal polyadenylation of COOLAIR, delivers a specific chromatin environment, which represses transcriptional output: and 2) explore the missing link between FCA/FY-mediated proximal polyadenylation of COOLAIR and chromatin regulation by FLD/SDG26 complex. My proposal involves interconnections between genetics, biochemistry and molecular biology, enabling me to develop a broader experimental skillset. It directly contributes to the action’s goals to: improve my creative potential and competences through international mobility and advanced training in technical and transferable skills; enhance collaborative and contact networks for both myself and my host lab through academic and public engagement; and drive substantial career development.

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