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WISDOM SIGNED

The autonomous floral pathway: a WIndow to Study the tight link between non-coDing RNA and chrOMatin regulation

Total Cost €

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EC-Contrib. €

0

Partnership

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 WISDOM project word cloud

Explore the words cloud of the WISDOM project. It provides you a very rough idea of what is the project "WISDOM" about.

demethylase    identification    lab    engagement    suggests    public    coolair    coding    unknown    specificity    explore    capitalize    transcription    networks    interconnections    h3k4    base    elusive    transcript    histone    biochemistry    skills    output    transferable    rna    fy    contact    fellowship    polyadenylation    deeper    methylate    genetics    training    expression    mediated    repressor    regulate    co    contributes    substantial    flc    reproductive    quantitative    nature    environment    sense    floral    stable    components    mechanism    proteomic    building    collaborative    splicing    mechanistic    delivers    central    molecular    link    generally    proximal    histones    creative    plays    skillset    controls    interconnection    fld    gained    antisense    repression    my    proteins    competences    eukaryotes    regulation    biology    experimental    fca    conserved    myself    transcriptional    plant    hypothesis    host    genome    career    goals    protein    action    missing    drive    domain    chromatin    represses    arabidopsis    alternative    me    international    mobility    silencing    triggered    strategy    locus    academic    sdg26   

Project "WISDOM" data sheet

The following table provides information about the project.

Coordinator
JOHN INNES CENTRE 

Organization address
address: NORWICH RESEARCH PARK COLNEY
city: NORWICH
postcode: NR4 7UH
website: www.jic.bbsrc.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-04-01   to  2020-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    JOHN INNES CENTRE UK (NORWICH) coordinator 195˙454.00

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 Project objective

My Fellowship will explore the interconnection between non-coding RNA and chromatin regulation. Building on a detailed mechanistic base, I will capitalize on the recent proteomic identification of a stable complex FLD/SDG26 by my host lab, which plays a central role in the co-transcriptional silencing of the Arabidopsis floral repressor locus FLC. This protein complex is central to a mechanism determining the quantitative expression level of FLC, and thus the reproductive strategy of the plant. However, these activities also regulate many other targets in the Arabidopsis genome and the conserved nature of the components suggests the deeper understanding gained from this study will be important generally across all eukaryotes. FLD is a histone demethylase with specificity for H3K4; SDG26 is a SET domain protein likely to methylate histones and other proteins, but whose specificity is currently unknown. The splicing and alternative processing of FLC antisense non-coding transcript, COOLAIR, is essential for the repression of FLC transcription. However, how the processing of COOLAIR controls sense transcription remains elusive. My proposal aims to: 1) test the hypothesis that the FLD/SDG26 complex, triggered by FCA/FY-mediated proximal polyadenylation of COOLAIR, delivers a specific chromatin environment, which represses transcriptional output: and 2) explore the missing link between FCA/FY-mediated proximal polyadenylation of COOLAIR and chromatin regulation by FLD/SDG26 complex. My proposal involves interconnections between genetics, biochemistry and molecular biology, enabling me to develop a broader experimental skillset. It directly contributes to the action’s goals to: improve my creative potential and competences through international mobility and advanced training in technical and transferable skills; enhance collaborative and contact networks for both myself and my host lab through academic and public engagement; and drive substantial career development.

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